Selective Fluorescent Probes for High-Throughput Functional Diagnostics of the Human Multidrug Transporter P-Glycoprotein (ABCB1)

The multidrug transporter ABCB1 (MDR1, Pgp) plays an important role in the absorption, distribution, metabolism, and elimination of a wide range of pharmaceutical compounds. Functional investigation of the ABCB1 expression is also essential in many diseases, including drug-resistant cancer, inflamma...

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Veröffentlicht in:	International journal of molecular sciences 2022-09, Vol.23 (18), p.10599
Hauptverfasser:	Szabó, Edit, Kulin, Anna, Jezsó, Bálint, Kucsma, Nóra, Sarkadi, Balázs, Várady, György
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporters Accumulation Acids Alzheimer's disease Automation Drug resistance Dyes Experiments Extrusion Flow cytometry Fluorescent indicators MDR1 protein Membranes P-Glycoprotein Proteins
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