Ozone Infiltration for Osteonecrosis of the Jaw Therapy: A Case Series
Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse reaction, mainly due to bone-modifying agents (BMA), and it is a potentially painful and debilitating condition. To date, the literature has reported a 90% rate of successful outcomes for MRONJ patients undergoing surgical trea...
Gespeichert in:
Veröffentlicht in: | Journal of clinical medicine 2022-09, Vol.11 (18), p.5307 |
---|---|
Hauptverfasser: | , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | |
---|---|
container_issue | 18 |
container_start_page | 5307 |
container_title | Journal of clinical medicine |
container_volume | 11 |
creator | Di Fede, Olga Del Gaizo, Carmine Panzarella, Vera La Mantia, Gaetano Tozzo, Pietro Di Grigoli, Anna Lo Casto, Antonio Mauceri, Rodolfo Campisi, Giuseppina |
description | Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse reaction, mainly due to bone-modifying agents (BMA), and it is a potentially painful and debilitating condition. To date, the literature has reported a 90% rate of successful outcomes for MRONJ patients undergoing surgical treatment. Particularly for patients with advanced disease stages who are unsuitable for surgery, prolonged medical treatment is required, with a consequent risk of the overuse of antibiotics and antibiotic resistance. The aim of this study is to evaluate the efficiency and safety of ozone, via oral mucosal infiltrations, in seven cancer patients with MRONJ, who are not eligible for surgery. The protocol (OZOPROMAF) consists of intratissue injections of an oxygen ozone (O2O3) mixture, which is applied until formation of a sequestrum and clinical healing. Follow-up was scheduled to confirm the healing of MRONJ and radiological evaluations by CBCT were planned. In order to assess the level of pain, a questionnaire including the Numeric Rating Scale for Pain (NRS Pain) was administered on the first visit, one day after treatment, and one week after treatment. After an application of OZOPROMAF, all patients reported discomfort for some hours, probably due to soft tissue pressure around the infiltration site. Thereafter, the discomfort subsided within 6–8 h. Complete mucosal healing of MRONJ occurred within a number of cycles ranging from 7 to 16. Complete resolution with an improvement in bone condition was observed in all patients. The MRONJ lesions of all patients healed after 18–24 months. The authors of this study contend that these preliminary results suggest the efficiency and safety of the O2O3 mixture. However, further research is required to confirm the efficacy of the O2O3 mixtures in MRONJ treatment, at least for patients who are unsuitable for surgery. |
doi_str_mv | 10.3390/jcm11185307 |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9502994</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2716553677</sourcerecordid><originalsourceid>FETCH-LOGICAL-c386t-1b81de6911cb0703d5376a4b4110ba5e6223b47283b111adb21cc9a5073b63453</originalsourceid><addsrcrecordid>eNpdkU1LAzEQhoMottSe_AMBL4Ks5mPzsR6EUqxWCj1YzyHZzdot201NdpX6601pkepcZmAeXt53BoBLjG4pzdDdKl9jjCWjSJyAPkFCJIhKeno098AwhBWKJWVKsDgHPcpxSjKW9sFk_u0aC6dNWdWt123lGlg6D-ehtXGRexeqAF0J26WFL_oLLpbW6832Ho7gWAcLX62vbLgAZ6Wugx0e-gC8TR4X4-dkNn-ajkezJKeStwk2EheWZxjnBglEC0YF16lJMUZGM8sJoSYVRFITU-nCEJznmWZIUMNpyugAPOx1N51Z2yK3TTRdq42v1tpvldOV-rtpqqV6d58qY4hkWRoFrg8C3n10NrRqXYXc1rVurOuCIgILLiNIInr1D125zjcx3o7ijFEuRKRu9tTuVMHb8tcMRmr3InX0IvoDjrGAcA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2716553677</pqid></control><display><type>article</type><title>Ozone Infiltration for Osteonecrosis of the Jaw Therapy: A Case Series</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Di Fede, Olga ; Del Gaizo, Carmine ; Panzarella, Vera ; La Mantia, Gaetano ; Tozzo, Pietro ; Di Grigoli, Anna ; Lo Casto, Antonio ; Mauceri, Rodolfo ; Campisi, Giuseppina</creator><creatorcontrib>Di Fede, Olga ; Del Gaizo, Carmine ; Panzarella, Vera ; La Mantia, Gaetano ; Tozzo, Pietro ; Di Grigoli, Anna ; Lo Casto, Antonio ; Mauceri, Rodolfo ; Campisi, Giuseppina</creatorcontrib><description>Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse reaction, mainly due to bone-modifying agents (BMA), and it is a potentially painful and debilitating condition. To date, the literature has reported a 90% rate of successful outcomes for MRONJ patients undergoing surgical treatment. Particularly for patients with advanced disease stages who are unsuitable for surgery, prolonged medical treatment is required, with a consequent risk of the overuse of antibiotics and antibiotic resistance. The aim of this study is to evaluate the efficiency and safety of ozone, via oral mucosal infiltrations, in seven cancer patients with MRONJ, who are not eligible for surgery. The protocol (OZOPROMAF) consists of intratissue injections of an oxygen ozone (O2O3) mixture, which is applied until formation of a sequestrum and clinical healing. Follow-up was scheduled to confirm the healing of MRONJ and radiological evaluations by CBCT were planned. In order to assess the level of pain, a questionnaire including the Numeric Rating Scale for Pain (NRS Pain) was administered on the first visit, one day after treatment, and one week after treatment. After an application of OZOPROMAF, all patients reported discomfort for some hours, probably due to soft tissue pressure around the infiltration site. Thereafter, the discomfort subsided within 6–8 h. Complete mucosal healing of MRONJ occurred within a number of cycles ranging from 7 to 16. Complete resolution with an improvement in bone condition was observed in all patients. The MRONJ lesions of all patients healed after 18–24 months. The authors of this study contend that these preliminary results suggest the efficiency and safety of the O2O3 mixture. However, further research is required to confirm the efficacy of the O2O3 mixtures in MRONJ treatment, at least for patients who are unsuitable for surgery.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm11185307</identifier><identifier>PMID: 36142954</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Clinical medicine ; Disease ; Pain ; Patients ; Questionnaires ; Radiation ; Tomography</subject><ispartof>Journal of clinical medicine, 2022-09, Vol.11 (18), p.5307</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-1b81de6911cb0703d5376a4b4110ba5e6223b47283b111adb21cc9a5073b63453</citedby><cites>FETCH-LOGICAL-c386t-1b81de6911cb0703d5376a4b4110ba5e6223b47283b111adb21cc9a5073b63453</cites><orcidid>0000-0002-9443-0495 ; 0000-0002-8453-0206 ; 0000-0002-4008-6502 ; 0000-0002-5562-7420 ; 0000-0001-6339-6020</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502994/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502994/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Di Fede, Olga</creatorcontrib><creatorcontrib>Del Gaizo, Carmine</creatorcontrib><creatorcontrib>Panzarella, Vera</creatorcontrib><creatorcontrib>La Mantia, Gaetano</creatorcontrib><creatorcontrib>Tozzo, Pietro</creatorcontrib><creatorcontrib>Di Grigoli, Anna</creatorcontrib><creatorcontrib>Lo Casto, Antonio</creatorcontrib><creatorcontrib>Mauceri, Rodolfo</creatorcontrib><creatorcontrib>Campisi, Giuseppina</creatorcontrib><title>Ozone Infiltration for Osteonecrosis of the Jaw Therapy: A Case Series</title><title>Journal of clinical medicine</title><description>Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse reaction, mainly due to bone-modifying agents (BMA), and it is a potentially painful and debilitating condition. To date, the literature has reported a 90% rate of successful outcomes for MRONJ patients undergoing surgical treatment. Particularly for patients with advanced disease stages who are unsuitable for surgery, prolonged medical treatment is required, with a consequent risk of the overuse of antibiotics and antibiotic resistance. The aim of this study is to evaluate the efficiency and safety of ozone, via oral mucosal infiltrations, in seven cancer patients with MRONJ, who are not eligible for surgery. The protocol (OZOPROMAF) consists of intratissue injections of an oxygen ozone (O2O3) mixture, which is applied until formation of a sequestrum and clinical healing. Follow-up was scheduled to confirm the healing of MRONJ and radiological evaluations by CBCT were planned. In order to assess the level of pain, a questionnaire including the Numeric Rating Scale for Pain (NRS Pain) was administered on the first visit, one day after treatment, and one week after treatment. After an application of OZOPROMAF, all patients reported discomfort for some hours, probably due to soft tissue pressure around the infiltration site. Thereafter, the discomfort subsided within 6–8 h. Complete mucosal healing of MRONJ occurred within a number of cycles ranging from 7 to 16. Complete resolution with an improvement in bone condition was observed in all patients. The MRONJ lesions of all patients healed after 18–24 months. The authors of this study contend that these preliminary results suggest the efficiency and safety of the O2O3 mixture. However, further research is required to confirm the efficacy of the O2O3 mixtures in MRONJ treatment, at least for patients who are unsuitable for surgery.</description><subject>Clinical medicine</subject><subject>Disease</subject><subject>Pain</subject><subject>Patients</subject><subject>Questionnaires</subject><subject>Radiation</subject><subject>Tomography</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkU1LAzEQhoMottSe_AMBL4Ks5mPzsR6EUqxWCj1YzyHZzdot201NdpX6601pkepcZmAeXt53BoBLjG4pzdDdKl9jjCWjSJyAPkFCJIhKeno098AwhBWKJWVKsDgHPcpxSjKW9sFk_u0aC6dNWdWt123lGlg6D-ehtXGRexeqAF0J26WFL_oLLpbW6832Ho7gWAcLX62vbLgAZ6Wugx0e-gC8TR4X4-dkNn-ajkezJKeStwk2EheWZxjnBglEC0YF16lJMUZGM8sJoSYVRFITU-nCEJznmWZIUMNpyugAPOx1N51Z2yK3TTRdq42v1tpvldOV-rtpqqV6d58qY4hkWRoFrg8C3n10NrRqXYXc1rVurOuCIgILLiNIInr1D125zjcx3o7ijFEuRKRu9tTuVMHb8tcMRmr3InX0IvoDjrGAcA</recordid><startdate>20220909</startdate><enddate>20220909</enddate><creator>Di Fede, Olga</creator><creator>Del Gaizo, Carmine</creator><creator>Panzarella, Vera</creator><creator>La Mantia, Gaetano</creator><creator>Tozzo, Pietro</creator><creator>Di Grigoli, Anna</creator><creator>Lo Casto, Antonio</creator><creator>Mauceri, Rodolfo</creator><creator>Campisi, Giuseppina</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9443-0495</orcidid><orcidid>https://orcid.org/0000-0002-8453-0206</orcidid><orcidid>https://orcid.org/0000-0002-4008-6502</orcidid><orcidid>https://orcid.org/0000-0002-5562-7420</orcidid><orcidid>https://orcid.org/0000-0001-6339-6020</orcidid></search><sort><creationdate>20220909</creationdate><title>Ozone Infiltration for Osteonecrosis of the Jaw Therapy: A Case Series</title><author>Di Fede, Olga ; Del Gaizo, Carmine ; Panzarella, Vera ; La Mantia, Gaetano ; Tozzo, Pietro ; Di Grigoli, Anna ; Lo Casto, Antonio ; Mauceri, Rodolfo ; Campisi, Giuseppina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-1b81de6911cb0703d5376a4b4110ba5e6223b47283b111adb21cc9a5073b63453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Clinical medicine</topic><topic>Disease</topic><topic>Pain</topic><topic>Patients</topic><topic>Questionnaires</topic><topic>Radiation</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Di Fede, Olga</creatorcontrib><creatorcontrib>Del Gaizo, Carmine</creatorcontrib><creatorcontrib>Panzarella, Vera</creatorcontrib><creatorcontrib>La Mantia, Gaetano</creatorcontrib><creatorcontrib>Tozzo, Pietro</creatorcontrib><creatorcontrib>Di Grigoli, Anna</creatorcontrib><creatorcontrib>Lo Casto, Antonio</creatorcontrib><creatorcontrib>Mauceri, Rodolfo</creatorcontrib><creatorcontrib>Campisi, Giuseppina</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Di Fede, Olga</au><au>Del Gaizo, Carmine</au><au>Panzarella, Vera</au><au>La Mantia, Gaetano</au><au>Tozzo, Pietro</au><au>Di Grigoli, Anna</au><au>Lo Casto, Antonio</au><au>Mauceri, Rodolfo</au><au>Campisi, Giuseppina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ozone Infiltration for Osteonecrosis of the Jaw Therapy: A Case Series</atitle><jtitle>Journal of clinical medicine</jtitle><date>2022-09-09</date><risdate>2022</risdate><volume>11</volume><issue>18</issue><spage>5307</spage><pages>5307-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse reaction, mainly due to bone-modifying agents (BMA), and it is a potentially painful and debilitating condition. To date, the literature has reported a 90% rate of successful outcomes for MRONJ patients undergoing surgical treatment. Particularly for patients with advanced disease stages who are unsuitable for surgery, prolonged medical treatment is required, with a consequent risk of the overuse of antibiotics and antibiotic resistance. The aim of this study is to evaluate the efficiency and safety of ozone, via oral mucosal infiltrations, in seven cancer patients with MRONJ, who are not eligible for surgery. The protocol (OZOPROMAF) consists of intratissue injections of an oxygen ozone (O2O3) mixture, which is applied until formation of a sequestrum and clinical healing. Follow-up was scheduled to confirm the healing of MRONJ and radiological evaluations by CBCT were planned. In order to assess the level of pain, a questionnaire including the Numeric Rating Scale for Pain (NRS Pain) was administered on the first visit, one day after treatment, and one week after treatment. After an application of OZOPROMAF, all patients reported discomfort for some hours, probably due to soft tissue pressure around the infiltration site. Thereafter, the discomfort subsided within 6–8 h. Complete mucosal healing of MRONJ occurred within a number of cycles ranging from 7 to 16. Complete resolution with an improvement in bone condition was observed in all patients. The MRONJ lesions of all patients healed after 18–24 months. The authors of this study contend that these preliminary results suggest the efficiency and safety of the O2O3 mixture. However, further research is required to confirm the efficacy of the O2O3 mixtures in MRONJ treatment, at least for patients who are unsuitable for surgery.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>36142954</pmid><doi>10.3390/jcm11185307</doi><orcidid>https://orcid.org/0000-0002-9443-0495</orcidid><orcidid>https://orcid.org/0000-0002-8453-0206</orcidid><orcidid>https://orcid.org/0000-0002-4008-6502</orcidid><orcidid>https://orcid.org/0000-0002-5562-7420</orcidid><orcidid>https://orcid.org/0000-0001-6339-6020</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 2077-0383 |
ispartof | Journal of clinical medicine, 2022-09, Vol.11 (18), p.5307 |
issn | 2077-0383 2077-0383 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9502994 |
source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
subjects | Clinical medicine Disease Pain Patients Questionnaires Radiation Tomography |
title | Ozone Infiltration for Osteonecrosis of the Jaw Therapy: A Case Series |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T19%3A59%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ozone%20Infiltration%20for%20Osteonecrosis%20of%20the%20Jaw%20Therapy:%20A%20Case%20Series&rft.jtitle=Journal%20of%20clinical%20medicine&rft.au=Di%20Fede,%20Olga&rft.date=2022-09-09&rft.volume=11&rft.issue=18&rft.spage=5307&rft.pages=5307-&rft.issn=2077-0383&rft.eissn=2077-0383&rft_id=info:doi/10.3390/jcm11185307&rft_dat=%3Cproquest_pubme%3E2716553677%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2716553677&rft_id=info:pmid/36142954&rfr_iscdi=true |