Effect of obstructive sleep apnoea syndrome and continuous positive airway pressure treatment on choroidal structure
Objectives To evaluate the effect of obstructive sleep apnoea syndrome (OSAS) and continuous positive airway pressure (CPAP) therapy on choroidal structural changes and choroidal vascularity index (CVI) in patients with OSAS. Methods Choroidal structural changes in patients with OSAS immediately aft...
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| Veröffentlicht in: | Eye (London) 2022-10, Vol.36 (10), p.1977-1981 |
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| container_issue | 10 |
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| container_title | Eye (London) |
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| creator | Altinel, Meltem Guzin Uslu, Hasim Kanra, Ayse Yagmur Dalkilic, Orhan |
| description | Objectives
To evaluate the effect of obstructive sleep apnoea syndrome (OSAS) and continuous positive airway pressure (CPAP) therapy on choroidal structural changes and choroidal vascularity index (CVI) in patients with OSAS.
Methods
Choroidal structural changes in patients with OSAS immediately after diagnosis and 12 months after CPAP treatment were evaluated and compared with healthy controls. The choroidal images on enhanced depth imaging optical coherence tomography (EDI-OCT) were binarized into luminal area (LA) and stromal area (SA) using the ImageJ software. CVI was calculated as the ratio of LA to total choroid area (TCA). The correlations between the results of polysomnography (PSG) and choroidal parameters were evaluated.
Results
A total of 48 eyes of 48 patients (22 patients with OSAS, and 26 controls) were included. The mean age of the patients was 47.21 ± 8.82 (range, 30–63) years. The mean CVI values were 68.10 ± 1.80% in the OSAS group before CPAP therapy, and 69.22 ± 1.40% in the control group (
p
|
| doi_str_mv | 10.1038/s41433-021-01790-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9500031</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2580699301</sourcerecordid><originalsourceid>FETCH-LOGICAL-c451t-a39ce5e46af4aae8cda5b0343ba8def50df5c8644c06939e55fb3fafce4a5ae63</originalsourceid><addsrcrecordid>eNp9kc1u1TAQRq0K1N4WXoCVJTZsAuPYzs8GCVUFKlXqBiR21sQZt6kSO9hJr-7b120qECy68mLOHM_Mx9g7AR8FyOZTUkJJWUApChB1C8X-iO2EqqtCK61esR20GoqyLH-dsNOU7gBysYZjdiJVVWYF7Nhy4RzZhQfHQ5eWuNpluCeeRqKZ4-wDIU8H38cwEUffcxv8Mvg1rInPIQ1PNA5xjwc-R0ppjcSXSLhM5LPWc3sbYhh6HPmmz8Ab9trhmOjt83vGfn69-HH-vbi6_nZ5_uWqsEqLpUDZWtKkKnQKkRrbo-5AKtlh05PT0Dttm0opC1UrW9LaddKhs6RQI1XyjH3evPPaTdTbPFHE0cxxmDAeTMDB_Fvxw625Cfcm3w1Aiiz48CyI4fdKaTHTkCyNI3rKFzClbvLXrYRH9P1_6F1Yo8_rmbIWVd2W0DaZKjfKxpBSJPdnGAHmMVSzhWpyqOYpVLPPTXJrShn2NxT_ql_oegAwNqlE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2716792098</pqid></control><display><type>article</type><title>Effect of obstructive sleep apnoea syndrome and continuous positive airway pressure treatment on choroidal structure</title><source>Springer Nature - Complete Springer Journals</source><source>PubMed Central</source><creator>Altinel, Meltem Guzin ; Uslu, Hasim ; Kanra, Ayse Yagmur ; Dalkilic, Orhan</creator><creatorcontrib>Altinel, Meltem Guzin ; Uslu, Hasim ; Kanra, Ayse Yagmur ; Dalkilic, Orhan</creatorcontrib><description>Objectives
To evaluate the effect of obstructive sleep apnoea syndrome (OSAS) and continuous positive airway pressure (CPAP) therapy on choroidal structural changes and choroidal vascularity index (CVI) in patients with OSAS.
Methods
Choroidal structural changes in patients with OSAS immediately after diagnosis and 12 months after CPAP treatment were evaluated and compared with healthy controls. The choroidal images on enhanced depth imaging optical coherence tomography (EDI-OCT) were binarized into luminal area (LA) and stromal area (SA) using the ImageJ software. CVI was calculated as the ratio of LA to total choroid area (TCA). The correlations between the results of polysomnography (PSG) and choroidal parameters were evaluated.
Results
A total of 48 eyes of 48 patients (22 patients with OSAS, and 26 controls) were included. The mean age of the patients was 47.21 ± 8.82 (range, 30–63) years. The mean CVI values were 68.10 ± 1.80% in the OSAS group before CPAP therapy, and 69.22 ± 1.40% in the control group (
p
< 0.05). After 12 months of regular CPAP therapy, the mean CVI value increased significantly to 69.15 ± 1.77%, and SA decreased significantly from 0.51 ± 0.07 mm
2
to 0.48 ± 0.07 mm
2
in the OSAS group (
p
< 0.05). No statistically significant correlation was found between the results of PSG and choroidal structural parameters.
Conclusion
According to our results, OSAS was associated with increased stromal oedema in the choroid, which improved after 12 months of regular CPAP therapy. CVI can be an important parameter for the follow-up of patients with OSAS.</description><identifier>ISSN: 0950-222X</identifier><identifier>EISSN: 1476-5454</identifier><identifier>DOI: 10.1038/s41433-021-01790-w</identifier><identifier>PMID: 34621030</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699/1785 ; 692/699/3161/3175 ; Apnea ; Continuous positive airway pressure ; Edema ; Laboratory Medicine ; Medicine ; Medicine & Public Health ; Ophthalmology ; Patients ; Pharmaceutical Sciences/Technology ; Respiratory tract ; Sleep ; Sleep apnea ; Sleep disorders ; Statistical analysis ; Surgery ; Surgical Oncology</subject><ispartof>Eye (London), 2022-10, Vol.36 (10), p.1977-1981</ispartof><rights>The Author(s), under exclusive licence to The Royal College of Ophthalmologists 2021</rights><rights>The Author(s), under exclusive licence to The Royal College of Ophthalmologists 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-a39ce5e46af4aae8cda5b0343ba8def50df5c8644c06939e55fb3fafce4a5ae63</citedby><cites>FETCH-LOGICAL-c451t-a39ce5e46af4aae8cda5b0343ba8def50df5c8644c06939e55fb3fafce4a5ae63</cites><orcidid>0000-0003-1359-8577 ; 0000-0001-6804-5510</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500031/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500031/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids></links><search><creatorcontrib>Altinel, Meltem Guzin</creatorcontrib><creatorcontrib>Uslu, Hasim</creatorcontrib><creatorcontrib>Kanra, Ayse Yagmur</creatorcontrib><creatorcontrib>Dalkilic, Orhan</creatorcontrib><title>Effect of obstructive sleep apnoea syndrome and continuous positive airway pressure treatment on choroidal structure</title><title>Eye (London)</title><addtitle>Eye</addtitle><description>Objectives
To evaluate the effect of obstructive sleep apnoea syndrome (OSAS) and continuous positive airway pressure (CPAP) therapy on choroidal structural changes and choroidal vascularity index (CVI) in patients with OSAS.
Methods
Choroidal structural changes in patients with OSAS immediately after diagnosis and 12 months after CPAP treatment were evaluated and compared with healthy controls. The choroidal images on enhanced depth imaging optical coherence tomography (EDI-OCT) were binarized into luminal area (LA) and stromal area (SA) using the ImageJ software. CVI was calculated as the ratio of LA to total choroid area (TCA). The correlations between the results of polysomnography (PSG) and choroidal parameters were evaluated.
Results
A total of 48 eyes of 48 patients (22 patients with OSAS, and 26 controls) were included. The mean age of the patients was 47.21 ± 8.82 (range, 30–63) years. The mean CVI values were 68.10 ± 1.80% in the OSAS group before CPAP therapy, and 69.22 ± 1.40% in the control group (
p
< 0.05). After 12 months of regular CPAP therapy, the mean CVI value increased significantly to 69.15 ± 1.77%, and SA decreased significantly from 0.51 ± 0.07 mm
2
to 0.48 ± 0.07 mm
2
in the OSAS group (
p
< 0.05). No statistically significant correlation was found between the results of PSG and choroidal structural parameters.
Conclusion
According to our results, OSAS was associated with increased stromal oedema in the choroid, which improved after 12 months of regular CPAP therapy. CVI can be an important parameter for the follow-up of patients with OSAS.</description><subject>692/699/1785</subject><subject>692/699/3161/3175</subject><subject>Apnea</subject><subject>Continuous positive airway pressure</subject><subject>Edema</subject><subject>Laboratory Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Patients</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Respiratory tract</subject><subject>Sleep</subject><subject>Sleep apnea</subject><subject>Sleep disorders</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><issn>0950-222X</issn><issn>1476-5454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kc1u1TAQRq0K1N4WXoCVJTZsAuPYzs8GCVUFKlXqBiR21sQZt6kSO9hJr-7b120qECy68mLOHM_Mx9g7AR8FyOZTUkJJWUApChB1C8X-iO2EqqtCK61esR20GoqyLH-dsNOU7gBysYZjdiJVVWYF7Nhy4RzZhQfHQ5eWuNpluCeeRqKZ4-wDIU8H38cwEUffcxv8Mvg1rInPIQ1PNA5xjwc-R0ppjcSXSLhM5LPWc3sbYhh6HPmmz8Ab9trhmOjt83vGfn69-HH-vbi6_nZ5_uWqsEqLpUDZWtKkKnQKkRrbo-5AKtlh05PT0Dttm0opC1UrW9LaddKhs6RQI1XyjH3evPPaTdTbPFHE0cxxmDAeTMDB_Fvxw625Cfcm3w1Aiiz48CyI4fdKaTHTkCyNI3rKFzClbvLXrYRH9P1_6F1Yo8_rmbIWVd2W0DaZKjfKxpBSJPdnGAHmMVSzhWpyqOYpVLPPTXJrShn2NxT_ql_oegAwNqlE</recordid><startdate>20221001</startdate><enddate>20221001</enddate><creator>Altinel, Meltem Guzin</creator><creator>Uslu, Hasim</creator><creator>Kanra, Ayse Yagmur</creator><creator>Dalkilic, Orhan</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1359-8577</orcidid><orcidid>https://orcid.org/0000-0001-6804-5510</orcidid></search><sort><creationdate>20221001</creationdate><title>Effect of obstructive sleep apnoea syndrome and continuous positive airway pressure treatment on choroidal structure</title><author>Altinel, Meltem Guzin ; Uslu, Hasim ; Kanra, Ayse Yagmur ; Dalkilic, Orhan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-a39ce5e46af4aae8cda5b0343ba8def50df5c8644c06939e55fb3fafce4a5ae63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>692/699/1785</topic><topic>692/699/3161/3175</topic><topic>Apnea</topic><topic>Continuous positive airway pressure</topic><topic>Edema</topic><topic>Laboratory Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Patients</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Respiratory tract</topic><topic>Sleep</topic><topic>Sleep apnea</topic><topic>Sleep disorders</topic><topic>Statistical analysis</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Altinel, Meltem Guzin</creatorcontrib><creatorcontrib>Uslu, Hasim</creatorcontrib><creatorcontrib>Kanra, Ayse Yagmur</creatorcontrib><creatorcontrib>Dalkilic, Orhan</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Eye (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Altinel, Meltem Guzin</au><au>Uslu, Hasim</au><au>Kanra, Ayse Yagmur</au><au>Dalkilic, Orhan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of obstructive sleep apnoea syndrome and continuous positive airway pressure treatment on choroidal structure</atitle><jtitle>Eye (London)</jtitle><stitle>Eye</stitle><date>2022-10-01</date><risdate>2022</risdate><volume>36</volume><issue>10</issue><spage>1977</spage><epage>1981</epage><pages>1977-1981</pages><issn>0950-222X</issn><eissn>1476-5454</eissn><abstract>Objectives
To evaluate the effect of obstructive sleep apnoea syndrome (OSAS) and continuous positive airway pressure (CPAP) therapy on choroidal structural changes and choroidal vascularity index (CVI) in patients with OSAS.
Methods
Choroidal structural changes in patients with OSAS immediately after diagnosis and 12 months after CPAP treatment were evaluated and compared with healthy controls. The choroidal images on enhanced depth imaging optical coherence tomography (EDI-OCT) were binarized into luminal area (LA) and stromal area (SA) using the ImageJ software. CVI was calculated as the ratio of LA to total choroid area (TCA). The correlations between the results of polysomnography (PSG) and choroidal parameters were evaluated.
Results
A total of 48 eyes of 48 patients (22 patients with OSAS, and 26 controls) were included. The mean age of the patients was 47.21 ± 8.82 (range, 30–63) years. The mean CVI values were 68.10 ± 1.80% in the OSAS group before CPAP therapy, and 69.22 ± 1.40% in the control group (
p
< 0.05). After 12 months of regular CPAP therapy, the mean CVI value increased significantly to 69.15 ± 1.77%, and SA decreased significantly from 0.51 ± 0.07 mm
2
to 0.48 ± 0.07 mm
2
in the OSAS group (
p
< 0.05). No statistically significant correlation was found between the results of PSG and choroidal structural parameters.
Conclusion
According to our results, OSAS was associated with increased stromal oedema in the choroid, which improved after 12 months of regular CPAP therapy. CVI can be an important parameter for the follow-up of patients with OSAS.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>34621030</pmid><doi>10.1038/s41433-021-01790-w</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-1359-8577</orcidid><orcidid>https://orcid.org/0000-0001-6804-5510</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Eye (London), 2022-10, Vol.36 (10), p.1977-1981 |
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| source | Springer Nature - Complete Springer Journals; PubMed Central |
| subjects | 692/699/1785 692/699/3161/3175 Apnea Continuous positive airway pressure Edema Laboratory Medicine Medicine Medicine & Public Health Ophthalmology Patients Pharmaceutical Sciences/Technology Respiratory tract Sleep Sleep apnea Sleep disorders Statistical analysis Surgery Surgical Oncology |
| title | Effect of obstructive sleep apnoea syndrome and continuous positive airway pressure treatment on choroidal structure |
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