A specialized tyrosine-based endocytosis signal in MR1 controls antigen presentation to MAIT cells

MR1 is a highly conserved microbial immune-detection system in mammals. It captures vitamin B-related metabolite antigens from diverse microbes and presents them at the cell surface to stimulate MR1-restricted lymphocytes including mucosal-associated invariant T (MAIT) cells. MR1 presentation and MA...

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Veröffentlicht in:	The Journal of cell biology 2022-12, Vol.221 (12), p.1
Hauptverfasser:	Lim, Hui Jing, Wubben, Jacinta M, Garcia, Cristian Pinero, Cruz-Gomez, Sebastian, Deng, Jieru, Mak, Jeffrey Y W, Hachani, Abderrahman, Anderson, Regan J, Painter, Gavin F, Goyette, Jesse, Amarasinghe, Shanika L, Ritchie, Matthew E, Roquilly, Antoine, Fairlie, David P, Gaus, Katharina, Rossjohn, Jamie, Villadangos, Jose A, McWilliam, Hamish E G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Protein Complex 2 - genetics Adaptor Protein Complex 2 - metabolism Adaptor proteins Antigen Presentation Antigens Biochemistry Cell recognition Cell surface Endocytosis Histocompatibility Antigens Class I - genetics Homeostasis Humans Immune system Immunology Internalization Life Sciences Lymphocyte Activation Lymphocytes Metabolites Microorganisms Minor Histocompatibility Antigens - genetics Minor Histocompatibility Antigens - metabolism Mucosal-Associated Invariant T Cells - metabolism Protein turnover Recognition Trafficking Tyrosine Vitamins
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