Allyl Isothiocyanate (AITC) Induces Apoptotic Cell Death In Vitro and Exhibits Anti-Tumor Activity in a Human Glioblastoma GBM8401/luc2 Model

Some clinically used anti-cancer drugs are obtained from natural products. Allyl isothiocyanate (AITC), a plant-derived compound abundant in cruciferous vegetables, has been shown to possess an anti-cancer ability in human cancer cell lines in vitro, including human brain glioma cells. However, the...

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Veröffentlicht in:	International journal of molecular sciences 2022-09, Vol.23 (18), p.10411
Hauptverfasser:	Lu, Kung-Wen, Lu, Tai-Jung, Chueh, Fu-Shin, Lai, Kuang-Chi, Hsia, Te-Chun, Peng, Shu-Fen, Cheng, Ching-Chang, Chou, Yu-Cheng, Hsu, Fei-Ting
Format:	Artikel
Sprache:	eng
Schlagworte:	Allyl isothiocyanate Animal models Antitumor activity Apoptosis BAX protein Bcl-2 protein Biocompatibility Bladder cancer Body weight Brain cancer Brain tumors Cancer Cancer therapies Caspase-3 Cell death Cell proliferation Cytotoxicity Gelatinase B Glioblastoma Glioblastoma cells Glioma Glioma cells Heart In vivo methods and tests Liver Medical prognosis Natural products Pathology Plants Protein expression Proteins Radiation Toxicity Tumor cell lines Tumors Vascular endothelial growth factor Western blotting Xenografts Xenotransplantation
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