Circulating Cell-Free DNA in Renal Cell Carcinoma: The New Era of Precision Medicine
Tumor biopsy is still the gold standard for diagnosing and prognosis renal cell carcinoma (RCC). However, its invasiveness, costs, and inability to accurately picture tumor heterogeneity represent major limitations to this procedure. Analysis of circulating cell-free DNA (cfDNA) is a non-invasive co...
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| Veröffentlicht in: | Cancers 2022-09, Vol.14 (18), p.4359 |
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| creator | Francini, Edoardo Fanelli, Giuseppe Nicolò Pederzoli, Filippo Spisak, Sandor Minonne, Erika Raffo, Massimiliano Pakula, Hubert Tisza, Viktoria Scatena, Cristian Naccarato, Antonio Giuseppe Loda, Massimo Nuzzo, Pier Vitale |
| description | Tumor biopsy is still the gold standard for diagnosing and prognosis renal cell carcinoma (RCC). However, its invasiveness, costs, and inability to accurately picture tumor heterogeneity represent major limitations to this procedure. Analysis of circulating cell-free DNA (cfDNA) is a non-invasive cost-effective technique that has the potential to ease cancer detection and prognosis. In particular, a growing body of evidence suggests that cfDNA could be a complementary tool to identify and prognosticate RCC while providing contemporary mutational profiling of the tumor. Further, recent research highlighted the role of cfDNA methylation profiling as a novel method for cancer detection and tissue-origin identification. This review synthesizes current knowledge on the diagnostic, prognostic, and predictive applications of cfDNA in RCC, with a specific focus on the potential role of cell-free methylated DNA (cfMeDNA). |
| doi_str_mv | 10.3390/cancers14184359 |
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However, its invasiveness, costs, and inability to accurately picture tumor heterogeneity represent major limitations to this procedure. Analysis of circulating cell-free DNA (cfDNA) is a non-invasive cost-effective technique that has the potential to ease cancer detection and prognosis. In particular, a growing body of evidence suggests that cfDNA could be a complementary tool to identify and prognosticate RCC while providing contemporary mutational profiling of the tumor. Further, recent research highlighted the role of cfDNA methylation profiling as a novel method for cancer detection and tissue-origin identification. This review synthesizes current knowledge on the diagnostic, prognostic, and predictive applications of cfDNA in RCC, with a specific focus on the potential role of cell-free methylated DNA (cfMeDNA).</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers14184359</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Biomarkers ; Biopsy ; Cancer therapies ; Carcinoma, Renal cell ; Care and treatment ; Classification systems ; Deoxyribonucleic acid ; Diagnosis ; DNA ; DNA methylation ; Epigenetics ; Genetic aspects ; Genomes ; Kidney cancer ; Kinases ; Metastasis ; Mutation ; Phenols ; Precision medicine ; Prognosis ; Renal cell carcinoma ; Review ; Tumors</subject><ispartof>Cancers, 2022-09, Vol.14 (18), p.4359</ispartof><rights>COPYRIGHT 2022 MDPI AG</rights><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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This review synthesizes current knowledge on the diagnostic, prognostic, and predictive applications of cfDNA in RCC, with a specific focus on the potential role of cell-free methylated DNA (cfMeDNA).</description><subject>Biomarkers</subject><subject>Biopsy</subject><subject>Cancer therapies</subject><subject>Carcinoma, Renal cell</subject><subject>Care and treatment</subject><subject>Classification systems</subject><subject>Deoxyribonucleic acid</subject><subject>Diagnosis</subject><subject>DNA</subject><subject>DNA methylation</subject><subject>Epigenetics</subject><subject>Genetic aspects</subject><subject>Genomes</subject><subject>Kidney cancer</subject><subject>Kinases</subject><subject>Metastasis</subject><subject>Mutation</subject><subject>Phenols</subject><subject>Precision medicine</subject><subject>Prognosis</subject><subject>Renal cell carcinoma</subject><subject>Review</subject><subject>Tumors</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptks1PHSEQwDemJhrr2StJL72swsLCbg9NXrZ-NPEr5nkmLDvzxOyChbdt_O_lqWnVFA6Q4Tc_GDJFccDoIectPbLGW4iJCdYIXrdbxW5FVVVK2YpPb_Y7xX5K9zQPzpmSardYdi7aeTRr51ekg3EsTyIA-XG5IM6TG_BmfA6TzkTrfJjMN7K8A3IJf8hxNCQguY5gXXLBkwsYXIbgc7GNZkyw_7ruFbcnx8vurDy_Ov3ZLc5LK2S9LuseBzkMkje0NVQxRbGRfYtoLLVoKXKJDUJjUTQgq7pmvO8Z2gFR2Yb3fK_4_uJ9mPsJBgt-Hc2oH6KbTHzUwTj9_sS7O70Kv3UrWsWYyIKvr4IYfs2Q1npyyeZyjYcwJ13lR8lWSaEy-uUDeh_mmL_nmZI1o6pu_lErM4J2HkO-126keqFEnUlRbVyH_6HyHGByNnhAl-PvEo5eEmwMKUXAvzUyqjcNoD80AH8CtUCjZA</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>Francini, Edoardo</creator><creator>Fanelli, Giuseppe Nicolò</creator><creator>Pederzoli, Filippo</creator><creator>Spisak, Sandor</creator><creator>Minonne, Erika</creator><creator>Raffo, Massimiliano</creator><creator>Pakula, Hubert</creator><creator>Tisza, Viktoria</creator><creator>Scatena, Cristian</creator><creator>Naccarato, Antonio Giuseppe</creator><creator>Loda, Massimo</creator><creator>Nuzzo, Pier Vitale</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8195-9445</orcidid><orcidid>https://orcid.org/0000-0001-9674-8379</orcidid><orcidid>https://orcid.org/0000-0002-5618-8079</orcidid><orcidid>https://orcid.org/0000-0001-7069-7980</orcidid><orcidid>https://orcid.org/0000-0003-3873-7465</orcidid><orcidid>https://orcid.org/0000-0003-4270-7023</orcidid><orcidid>https://orcid.org/0000-0002-4862-0845</orcidid></search><sort><creationdate>20220901</creationdate><title>Circulating Cell-Free DNA in Renal Cell Carcinoma: The New Era of Precision Medicine</title><author>Francini, Edoardo ; 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However, its invasiveness, costs, and inability to accurately picture tumor heterogeneity represent major limitations to this procedure. Analysis of circulating cell-free DNA (cfDNA) is a non-invasive cost-effective technique that has the potential to ease cancer detection and prognosis. In particular, a growing body of evidence suggests that cfDNA could be a complementary tool to identify and prognosticate RCC while providing contemporary mutational profiling of the tumor. Further, recent research highlighted the role of cfDNA methylation profiling as a novel method for cancer detection and tissue-origin identification. 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| subjects | Biomarkers Biopsy Cancer therapies Carcinoma, Renal cell Care and treatment Classification systems Deoxyribonucleic acid Diagnosis DNA DNA methylation Epigenetics Genetic aspects Genomes Kidney cancer Kinases Metastasis Mutation Phenols Precision medicine Prognosis Renal cell carcinoma Review Tumors |
| title | Circulating Cell-Free DNA in Renal Cell Carcinoma: The New Era of Precision Medicine |
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