Sex-Specific Association Between Iron Status and the Predicted 10-Year Risk for Atherosclerotic Cardiovascular Disease in Hypertensive Patients
Serum ferritin (SF) and haemoglobin (Hb) are widely used in clinical practice to assess iron status. Studies exploring the relationship of SF and Hb with atherosclerotic cardiovascular disease (ASCVD) risk have yielded conflicting results, and some indicated sex specificity. Hypertensive patients ha...
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| Veröffentlicht in: | Biological trace element research 2022-11, Vol.200 (11), p.4594-4607 |
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| creator | Zhou, Juan Zhao, Rui Wang, Dongxia Gao, Qin Zhao, Dan Ouyang, Binfa Hao, Liping Peng, Xiaolin |
| description | Serum ferritin (SF) and haemoglobin (Hb) are widely used in clinical practice to assess iron status. Studies exploring the relationship of SF and Hb with atherosclerotic cardiovascular disease (ASCVD) risk have yielded conflicting results, and some indicated sex specificity. Hypertensive patients have abnormal iron status. However, research on patients with hypertension is limited. We aim to investigate the sex-specific links of SF and Hb with the predicted 10-year ASCVD risk in hypertensive patients. This cross-sectional study included 718 hypertensive men and 708 hypertensive women. The predicted 10-year ASCVD risk was calculated based on the China-PAR equation. The dose–response curves were illustrated by fitting linear and quadratic models. In hypertensive men, the iron status fits for a quadratic model for ASCVD risk, showing a U-shape. After adjusting for potential confounding factors, the regression coefficients and 95% confidence intervals (95% CI) across tertile of SF were 0.0 (reference), − 0.99 (− 1.65, − 0.33) and − 0.22 (− 0.88, 0.44), and of Hb were 0.0 (reference), − 0.74 (− 1.41, − 0.08) and − 0.77 (− 1.46, − 0.08). In hypertensive women, iron status was linearly and positively associated with ASCVD risk. Per one unit increment of log-transformed SF as well as Hb was associated with a 1.22 (95% CI: 0.97, 1.48) and 0.04 (95% CI: 0.02, 0.07) increased in ASCVD risk score, respectively. A significant interaction between iron status and inflammation on ASCVD risk was observed in hypertensive women. SF and Hb showed a U-shape with ASCVD risk in hypertensive men; however, a positive linear relationship was observed in hypertensive women. |
| doi_str_mv | 10.1007/s12011-021-03060-y |
| format | Article |
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Studies exploring the relationship of SF and Hb with atherosclerotic cardiovascular disease (ASCVD) risk have yielded conflicting results, and some indicated sex specificity. Hypertensive patients have abnormal iron status. However, research on patients with hypertension is limited. We aim to investigate the sex-specific links of SF and Hb with the predicted 10-year ASCVD risk in hypertensive patients. This cross-sectional study included 718 hypertensive men and 708 hypertensive women. The predicted 10-year ASCVD risk was calculated based on the China-PAR equation. The dose–response curves were illustrated by fitting linear and quadratic models. In hypertensive men, the iron status fits for a quadratic model for ASCVD risk, showing a U-shape. After adjusting for potential confounding factors, the regression coefficients and 95% confidence intervals (95% CI) across tertile of SF were 0.0 (reference), − 0.99 (− 1.65, − 0.33) and − 0.22 (− 0.88, 0.44), and of Hb were 0.0 (reference), − 0.74 (− 1.41, − 0.08) and − 0.77 (− 1.46, − 0.08). In hypertensive women, iron status was linearly and positively associated with ASCVD risk. Per one unit increment of log-transformed SF as well as Hb was associated with a 1.22 (95% CI: 0.97, 1.48) and 0.04 (95% CI: 0.02, 0.07) increased in ASCVD risk score, respectively. A significant interaction between iron status and inflammation on ASCVD risk was observed in hypertensive women. SF and Hb showed a U-shape with ASCVD risk in hypertensive men; however, a positive linear relationship was observed in hypertensive women.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-021-03060-y</identifier><identifier>PMID: 35067842</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Arteriosclerosis ; Atherosclerosis ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; Cardiovascular disease ; Cardiovascular Diseases ; Coefficients ; Cross-Sectional Studies ; Female ; Ferritin ; Ferritins ; Haemoglobin ; Hemoglobin ; Hemoglobins - analysis ; Humans ; Hypertension ; Iron ; Life Sciences ; Male ; Mathematical models ; Men ; Nutrition ; Oncology ; Patients ; Regression coefficients ; Risk ; Risk Assessment ; Risk Factors ; Serum ; Sex ; Shape ; Specificity ; Statistical analysis ; Women</subject><ispartof>Biological trace element research, 2022-11, Vol.200 (11), p.4594-4607</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-571516d4db9c4079308dfc498be7e7e2a589e37d8362f58da728ffd320e8da0b3</citedby><cites>FETCH-LOGICAL-c474t-571516d4db9c4079308dfc498be7e7e2a589e37d8362f58da728ffd320e8da0b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12011-021-03060-y$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12011-021-03060-y$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35067842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Juan</creatorcontrib><creatorcontrib>Zhao, Rui</creatorcontrib><creatorcontrib>Wang, Dongxia</creatorcontrib><creatorcontrib>Gao, Qin</creatorcontrib><creatorcontrib>Zhao, Dan</creatorcontrib><creatorcontrib>Ouyang, Binfa</creatorcontrib><creatorcontrib>Hao, Liping</creatorcontrib><creatorcontrib>Peng, Xiaolin</creatorcontrib><title>Sex-Specific Association Between Iron Status and the Predicted 10-Year Risk for Atherosclerotic Cardiovascular Disease in Hypertensive Patients</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><addtitle>Biol Trace Elem Res</addtitle><description>Serum ferritin (SF) and haemoglobin (Hb) are widely used in clinical practice to assess iron status. Studies exploring the relationship of SF and Hb with atherosclerotic cardiovascular disease (ASCVD) risk have yielded conflicting results, and some indicated sex specificity. Hypertensive patients have abnormal iron status. However, research on patients with hypertension is limited. We aim to investigate the sex-specific links of SF and Hb with the predicted 10-year ASCVD risk in hypertensive patients. This cross-sectional study included 718 hypertensive men and 708 hypertensive women. The predicted 10-year ASCVD risk was calculated based on the China-PAR equation. The dose–response curves were illustrated by fitting linear and quadratic models. In hypertensive men, the iron status fits for a quadratic model for ASCVD risk, showing a U-shape. After adjusting for potential confounding factors, the regression coefficients and 95% confidence intervals (95% CI) across tertile of SF were 0.0 (reference), − 0.99 (− 1.65, − 0.33) and − 0.22 (− 0.88, 0.44), and of Hb were 0.0 (reference), − 0.74 (− 1.41, − 0.08) and − 0.77 (− 1.46, − 0.08). In hypertensive women, iron status was linearly and positively associated with ASCVD risk. Per one unit increment of log-transformed SF as well as Hb was associated with a 1.22 (95% CI: 0.97, 1.48) and 0.04 (95% CI: 0.02, 0.07) increased in ASCVD risk score, respectively. A significant interaction between iron status and inflammation on ASCVD risk was observed in hypertensive women. SF and Hb showed a U-shape with ASCVD risk in hypertensive men; however, a positive linear relationship was observed in hypertensive women.</description><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases</subject><subject>Coefficients</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Ferritin</subject><subject>Ferritins</subject><subject>Haemoglobin</subject><subject>Hemoglobin</subject><subject>Hemoglobins - analysis</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Iron</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Mathematical models</subject><subject>Men</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>Patients</subject><subject>Regression coefficients</subject><subject>Risk</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Serum</subject><subject>Sex</subject><subject>Shape</subject><subject>Specificity</subject><subject>Statistical analysis</subject><subject>Women</subject><issn>0163-4984</issn><issn>1559-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9UctuEzEUtRCIpoEfYIEssWEz4MfM2LNBCuHRSpVABBasLMe-07pMPMH2hOYr-GVuSSmPBbJs6-qee46PDyGPOHvGGVPPMxeM84oJ3JK1rNrfITPeNF3FlGB3yYzxVlZ1p-sjcpzzJWNciU7eJ0eyYa3StZiR7yu4qlZbcKEPji5yHl2wJYyRvoTyDSDS04TFqtgyZWqjp-UC6PsEPrgCnnJWfQab6IeQv9B-THSB_TRmN-BZkHJpkw_jzmY3DYh7FTLYDDREerLfQioQc9ghI4pCLPkBudfbIcPDm3tOPr15_XF5Up29e3u6XJxVrlZ1qRrFG9762q87VzPVSaZ979DqGhQuYRvdgVRey1b0jfZWCd33XgoGWLC1nJMXB97ttN6Ad6id7GC2KWxs2pvRBvN3J4YLcz7uTFd3okHBOXl6Q5DGrxPkYjYhOxgGG2GcshGtELVinZYIffIP9HKcUkR7RiiMSOu2uSYUB5TD78sJ-tvHcGau8zaHvA3mbX7mbfY49PhPG7cjvwJGgDwAMrbiOaTf2v-h_QFiKrk3</recordid><startdate>20221101</startdate><enddate>20221101</enddate><creator>Zhou, Juan</creator><creator>Zhao, Rui</creator><creator>Wang, Dongxia</creator><creator>Gao, Qin</creator><creator>Zhao, Dan</creator><creator>Ouyang, Binfa</creator><creator>Hao, Liping</creator><creator>Peng, Xiaolin</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QH</scope><scope>7QP</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H97</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20221101</creationdate><title>Sex-Specific Association Between Iron Status and the Predicted 10-Year Risk for Atherosclerotic Cardiovascular Disease in Hypertensive Patients</title><author>Zhou, Juan ; Zhao, Rui ; Wang, Dongxia ; Gao, Qin ; Zhao, Dan ; Ouyang, Binfa ; Hao, Liping ; Peng, Xiaolin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-571516d4db9c4079308dfc498be7e7e2a589e37d8362f58da728ffd320e8da0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular Diseases</topic><topic>Coefficients</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Ferritin</topic><topic>Ferritins</topic><topic>Haemoglobin</topic><topic>Hemoglobin</topic><topic>Hemoglobins - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biological trace element research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Juan</au><au>Zhao, Rui</au><au>Wang, Dongxia</au><au>Gao, Qin</au><au>Zhao, Dan</au><au>Ouyang, Binfa</au><au>Hao, Liping</au><au>Peng, Xiaolin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex-Specific Association Between Iron Status and the Predicted 10-Year Risk for Atherosclerotic Cardiovascular Disease in Hypertensive Patients</atitle><jtitle>Biological trace element research</jtitle><stitle>Biol Trace Elem Res</stitle><addtitle>Biol Trace Elem Res</addtitle><date>2022-11-01</date><risdate>2022</risdate><volume>200</volume><issue>11</issue><spage>4594</spage><epage>4607</epage><pages>4594-4607</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><abstract>Serum ferritin (SF) and haemoglobin (Hb) are widely used in clinical practice to assess iron status. Studies exploring the relationship of SF and Hb with atherosclerotic cardiovascular disease (ASCVD) risk have yielded conflicting results, and some indicated sex specificity. Hypertensive patients have abnormal iron status. However, research on patients with hypertension is limited. We aim to investigate the sex-specific links of SF and Hb with the predicted 10-year ASCVD risk in hypertensive patients. This cross-sectional study included 718 hypertensive men and 708 hypertensive women. The predicted 10-year ASCVD risk was calculated based on the China-PAR equation. The dose–response curves were illustrated by fitting linear and quadratic models. In hypertensive men, the iron status fits for a quadratic model for ASCVD risk, showing a U-shape. After adjusting for potential confounding factors, the regression coefficients and 95% confidence intervals (95% CI) across tertile of SF were 0.0 (reference), − 0.99 (− 1.65, − 0.33) and − 0.22 (− 0.88, 0.44), and of Hb were 0.0 (reference), − 0.74 (− 1.41, − 0.08) and − 0.77 (− 1.46, − 0.08). In hypertensive women, iron status was linearly and positively associated with ASCVD risk. Per one unit increment of log-transformed SF as well as Hb was associated with a 1.22 (95% CI: 0.97, 1.48) and 0.04 (95% CI: 0.02, 0.07) increased in ASCVD risk score, respectively. A significant interaction between iron status and inflammation on ASCVD risk was observed in hypertensive women. SF and Hb showed a U-shape with ASCVD risk in hypertensive men; however, a positive linear relationship was observed in hypertensive women.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>35067842</pmid><doi>10.1007/s12011-021-03060-y</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Arteriosclerosis Atherosclerosis Biochemistry Biomedical and Life Sciences Biotechnology Cardiovascular disease Cardiovascular Diseases Coefficients Cross-Sectional Studies Female Ferritin Ferritins Haemoglobin Hemoglobin Hemoglobins - analysis Humans Hypertension Iron Life Sciences Male Mathematical models Men Nutrition Oncology Patients Regression coefficients Risk Risk Assessment Risk Factors Serum Sex Shape Specificity Statistical analysis Women |
| title | Sex-Specific Association Between Iron Status and the Predicted 10-Year Risk for Atherosclerotic Cardiovascular Disease in Hypertensive Patients |
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