Atractylenolide III Attenuates Apoptosis in H9c2 Cells by Inhibiting Endoplasmic Reticulum Stress through the GRP78/PERK/CHOP Signaling Pathway

The objective of this study was to determine the effect of atractylenolide III (ATL-III) on endoplasmic reticulum stress (ERS) injury, H9c2 cardiomyocyte apoptosis induced by tunicamycin (TM), and the GRP78/PERK/CHOP signaling pathway. Molecular docking was applied to predict the binding affinity of...

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Veröffentlicht in:	Evidence-based complementary and alternative medicine 2022-09, Vol.2022, p.1-12
Hauptverfasser:	Zuo, Meng-yu, Tang, Tong-juan, Wang, Xiang, Gu, Jin-fan, Wang, Liang, Chen, Jian, Yao, Juan, Li, Xiang-yang, Zhou, Peng, Huang, Jin-ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Antibodies Apoptosis BAX protein Bcl-2 protein Cardiomyocytes Caspase-3 Cell viability Chinese medicine Endoplasmic reticulum Experiments Flow cytometry Heart failure Kinases Medical prognosis mRNA Oxidative stress Pathogenesis Phenylbutyric acid Proteins Signal transduction Tunicamycin
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