Effect of Roflumilast Cream vs Vehicle Cream on Chronic Plaque Psoriasis: The DERMIS-1 and DERMIS-2 Randomized Clinical Trials

IMPORTANCE: Once-daily roflumilast cream, 0.3%, a potent phosphodiesterase 4 inhibitor, demonstrated efficacy and was well tolerated in a phase 2b trial of patients with psoriasis. OBJECTIVE: To evaluate the efficacy of roflumilast cream, 0.3%, applied once daily for 8 weeks in 2 trials of patients...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 2022-09, Vol.328 (11), p.1073-1084
Hauptverfasser:	Lebwohl, Mark G, Kircik, Leon H, Moore, Angela Y, Stein Gold, Linda, Draelos, Zoe D, Gooderham, Melinda J, Papp, Kim A, Bagel, Jerry, Bhatia, Neal, Del Rosso, James Q, Ferris, Laura K, Green, Lawrence J, Hebert, Adelaide A, Jones, Terry, Kempers, Steven E, Pariser, David M, Yamauchi, Paul S, Zirwas, Matthew, Albrecht, Lorne, Devani, Alim R, Lomaga, Mark, Feng, Amy, Snyder, Scott, Burnett, Patrick, Higham, Robert C, Berk, David R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adverse events Aminopyridines - administration & dosage Aminopyridines - adverse effects Aminopyridines - therapeutic use Benzamides - administration & dosage Benzamides - adverse effects Benzamides - therapeutic use Clinical trials Cyclopropanes - administration & dosage Cyclopropanes - adverse effects Cyclopropanes - therapeutic use Dermis Double-blind studies Effectiveness Female Humans Immunoglobulin A Male Middle Aged Original Investigation Patients Phosphodiesterase Phosphodiesterase 4 Inhibitors - administration & dosage Phosphodiesterase 4 Inhibitors - adverse effects Phosphodiesterase 4 Inhibitors - therapeutic use Phosphodiesterase IV Pruritus - drug therapy Pruritus - etiology Psoriasis Psoriasis - complications Psoriasis - drug therapy Quality Randomized Controlled Trials as Topic Reduction Skin Cream - administration & dosage Skin Cream - adverse effects Skin Cream - therapeutic use Skin diseases Statistical analysis Success
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