O-GlcNAcylation suppresses TRAP1 activity and promotes mitochondrial respiration

The molecular chaperone TNF-receptor-associated protein-1 (TRAP1) controls mitochondrial respiration through regulation of Krebs cycle and electron transport chain activity. Post-translational modification (PTM) of TRAP1 regulates its activity, thereby controlling global metabolic flux. O-GlcNAcylat...

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Veröffentlicht in:	Cell stress & chaperones 2022-09, Vol.27 (5), p.573-585
Hauptverfasser:	Kim, Seungchan, Backe, Sarah J., Wengert, Laura A., Johnson, Anna E., Isakov, Roman V., Bratslavsky, Michael S., Woodford, Mark R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism Adenosine Triphosphate - metabolism Biochemistry Biomedical and Life Sciences Biomedicine Cancer Research Cell Biology Electron transport Electron transport chain HSP90 Heat-Shock Proteins - metabolism Humans Immunology Krebs cycle Metabolic flux Metabolism Mitochondria Molecular Chaperones - metabolism Neurosciences O-GlcNAcylation Original ORIGINAL ARTICLE Post-translation Protein Processing, Post-Translational Proteins Respiration Succinate dehydrogenase Succinate Dehydrogenase - metabolism TNF Receptor-Associated Factor 1 - chemistry TNF Receptor-Associated Factor 1 - metabolism Tricarboxylic acid cycle
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