Waning locus coeruleus integrity precedes cortical tau accrual in preclinical autosomal dominant Alzheimer's disease

Introduction Autopsy studies recognize the locus coeruleus (LC) as one of the first sites accumulating tau in Alzheimer's disease (AD). Recent AD work related in vivo LC magnetic resonance imaging (MRI) integrity to tau and cognitive decline; however, relationships of LC integrity to age, tau,...

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Veröffentlicht in:	Alzheimer's & dementia 2023-01, Vol.19 (1), p.169-180
Hauptverfasser:	Jacobs, Heidi I.L., Becker, John Alex, Kwong, Kenneth, Munera, Diana, Ramirez‐Gomez, Liliana, Engels‐Domínguez, Nina, Sanchez, Justin S, Vila‐Castelar, Clara, Baena, Ana, Sperling, Reisa A., Johnson, Keith A., Lopera, Francisco, Quiroz, Yakeel T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alzheimer Disease - diagnostic imaging Alzheimer Disease - genetics Alzheimer's disease Amyloid beta-Peptides - metabolism autosomal dominant brainstem Cognitive Dysfunction early onset Humans Locus Coeruleus Mutation - genetics Positron-Emission Tomography - methods Presenilin-1 - genetics tau tau Proteins - genetics tau Proteins - metabolism
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