Waning locus coeruleus integrity precedes cortical tau accrual in preclinical autosomal dominant Alzheimer's disease
Introduction Autopsy studies recognize the locus coeruleus (LC) as one of the first sites accumulating tau in Alzheimer's disease (AD). Recent AD work related in vivo LC magnetic resonance imaging (MRI) integrity to tau and cognitive decline; however, relationships of LC integrity to age, tau,...
Gespeichert in:
| Veröffentlicht in: | Alzheimer's & dementia 2023-01, Vol.19 (1), p.169-180 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 180 |
|---|---|
| container_issue | 1 |
| container_start_page | 169 |
| container_title | Alzheimer's & dementia |
| container_volume | 19 |
| creator | Jacobs, Heidi I.L. Becker, John Alex Kwong, Kenneth Munera, Diana Ramirez‐Gomez, Liliana Engels‐Domínguez, Nina Sanchez, Justin S Vila‐Castelar, Clara Baena, Ana Sperling, Reisa A. Johnson, Keith A. Lopera, Francisco Quiroz, Yakeel T. |
| description | Introduction
Autopsy studies recognize the locus coeruleus (LC) as one of the first sites accumulating tau in Alzheimer's disease (AD). Recent AD work related in vivo LC magnetic resonance imaging (MRI) integrity to tau and cognitive decline; however, relationships of LC integrity to age, tau, and cognition in autosomal dominant AD (ADAD) remain unexplored.
Methods
We associated LC integrity (3T‐MRI) with estimated years of onset, cortical amyloid beta, regional tau (positron emission tomography [PET]) and memory (Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Word‐List‐Learning) among 27 carriers and 27 non‐carriers of the presenilin‐1 (PSEN1) E280A mutation. Longitudinal changes between LC integrity and tau were evaluated in 10 carriers.
Results
LC integrity started to decline at age 32 in carriers, 12 years before clinical onset, and 20 years earlier than in sporadic AD. LC integrity was negatively associated with cortical tau, independent of amyloid beta, and predicted precuneus tau increases. LC integrity was positively associated with memory.
Discussion
These findings support LC integrity as marker of disease progression in preclinical ADAD. |
| doi_str_mv | 10.1002/alz.12656 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9481982</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2640322132</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3806-568e54c6d3b52c30c1926becfa7418de86ac49aa89163f83279c726f312dce973</originalsourceid><addsrcrecordid>eNp1kU9vEzEQxS1ERUvhwBdAe6M9pPWfteO9IEVVC0iRuICQuFgT72xq5LWD7QWlnx4nKRE9cPKT309vZvQIecPoFaOUX4N_uGJcSfWMnDEp-Uzyeff8qBU9JS9z_kFpSzWTL8ipkLzTVIszUr5BcGHd-Gin3NiIafJYlQsF18mVbbNJaLHHnZmKs-CbAlMD1qapahf2gHdhb8FUYo5jVX0cXYBQmoV_uEc3YnqXm95lhIyvyMkAPuPrx_ecfL27_XLzcbb8_OHTzWI5s0JTNZNKo2yt6sVKciuoZR1XK7QDzFume9QKbNsB6I4pMWhRj7ZzrgbBeG-xm4tz8v6Qu5lWI9a_UBJ4s0luhLQ1EZx56gR3b9bxl-lazTrNa8DFY0CKPyfMxYwuW_QeAsYpG65aKjhnYodeHlCbYs4Jh-MYRs2uJVNbMvuWKvv2372O5N9aKnB9AH47j9v_J5nF8vsh8g_1VJ-m</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2640322132</pqid></control><display><type>article</type><title>Waning locus coeruleus integrity precedes cortical tau accrual in preclinical autosomal dominant Alzheimer's disease</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Jacobs, Heidi I.L. ; Becker, John Alex ; Kwong, Kenneth ; Munera, Diana ; Ramirez‐Gomez, Liliana ; Engels‐Domínguez, Nina ; Sanchez, Justin S ; Vila‐Castelar, Clara ; Baena, Ana ; Sperling, Reisa A. ; Johnson, Keith A. ; Lopera, Francisco ; Quiroz, Yakeel T.</creator><creatorcontrib>Jacobs, Heidi I.L. ; Becker, John Alex ; Kwong, Kenneth ; Munera, Diana ; Ramirez‐Gomez, Liliana ; Engels‐Domínguez, Nina ; Sanchez, Justin S ; Vila‐Castelar, Clara ; Baena, Ana ; Sperling, Reisa A. ; Johnson, Keith A. ; Lopera, Francisco ; Quiroz, Yakeel T.</creatorcontrib><description>Introduction
Autopsy studies recognize the locus coeruleus (LC) as one of the first sites accumulating tau in Alzheimer's disease (AD). Recent AD work related in vivo LC magnetic resonance imaging (MRI) integrity to tau and cognitive decline; however, relationships of LC integrity to age, tau, and cognition in autosomal dominant AD (ADAD) remain unexplored.
Methods
We associated LC integrity (3T‐MRI) with estimated years of onset, cortical amyloid beta, regional tau (positron emission tomography [PET]) and memory (Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Word‐List‐Learning) among 27 carriers and 27 non‐carriers of the presenilin‐1 (PSEN1) E280A mutation. Longitudinal changes between LC integrity and tau were evaluated in 10 carriers.
Results
LC integrity started to decline at age 32 in carriers, 12 years before clinical onset, and 20 years earlier than in sporadic AD. LC integrity was negatively associated with cortical tau, independent of amyloid beta, and predicted precuneus tau increases. LC integrity was positively associated with memory.
Discussion
These findings support LC integrity as marker of disease progression in preclinical ADAD.</description><identifier>ISSN: 1552-5260</identifier><identifier>ISSN: 1552-5279</identifier><identifier>EISSN: 1552-5279</identifier><identifier>DOI: 10.1002/alz.12656</identifier><identifier>PMID: 35298083</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Alzheimer Disease - diagnostic imaging ; Alzheimer Disease - genetics ; Alzheimer's disease ; Amyloid beta-Peptides - metabolism ; autosomal dominant ; brainstem ; Cognitive Dysfunction ; early onset ; Humans ; Locus Coeruleus ; Mutation - genetics ; Positron-Emission Tomography - methods ; Presenilin-1 - genetics ; tau ; tau Proteins - genetics ; tau Proteins - metabolism</subject><ispartof>Alzheimer's & dementia, 2023-01, Vol.19 (1), p.169-180</ispartof><rights>2022 the Alzheimer's Association</rights><rights>2022 the Alzheimer's Association.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3806-568e54c6d3b52c30c1926becfa7418de86ac49aa89163f83279c726f312dce973</citedby><cites>FETCH-LOGICAL-c3806-568e54c6d3b52c30c1926becfa7418de86ac49aa89163f83279c726f312dce973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Falz.12656$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Falz.12656$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35298083$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jacobs, Heidi I.L.</creatorcontrib><creatorcontrib>Becker, John Alex</creatorcontrib><creatorcontrib>Kwong, Kenneth</creatorcontrib><creatorcontrib>Munera, Diana</creatorcontrib><creatorcontrib>Ramirez‐Gomez, Liliana</creatorcontrib><creatorcontrib>Engels‐Domínguez, Nina</creatorcontrib><creatorcontrib>Sanchez, Justin S</creatorcontrib><creatorcontrib>Vila‐Castelar, Clara</creatorcontrib><creatorcontrib>Baena, Ana</creatorcontrib><creatorcontrib>Sperling, Reisa A.</creatorcontrib><creatorcontrib>Johnson, Keith A.</creatorcontrib><creatorcontrib>Lopera, Francisco</creatorcontrib><creatorcontrib>Quiroz, Yakeel T.</creatorcontrib><title>Waning locus coeruleus integrity precedes cortical tau accrual in preclinical autosomal dominant Alzheimer's disease</title><title>Alzheimer's & dementia</title><addtitle>Alzheimers Dement</addtitle><description>Introduction
Autopsy studies recognize the locus coeruleus (LC) as one of the first sites accumulating tau in Alzheimer's disease (AD). Recent AD work related in vivo LC magnetic resonance imaging (MRI) integrity to tau and cognitive decline; however, relationships of LC integrity to age, tau, and cognition in autosomal dominant AD (ADAD) remain unexplored.
Methods
We associated LC integrity (3T‐MRI) with estimated years of onset, cortical amyloid beta, regional tau (positron emission tomography [PET]) and memory (Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Word‐List‐Learning) among 27 carriers and 27 non‐carriers of the presenilin‐1 (PSEN1) E280A mutation. Longitudinal changes between LC integrity and tau were evaluated in 10 carriers.
Results
LC integrity started to decline at age 32 in carriers, 12 years before clinical onset, and 20 years earlier than in sporadic AD. LC integrity was negatively associated with cortical tau, independent of amyloid beta, and predicted precuneus tau increases. LC integrity was positively associated with memory.
Discussion
These findings support LC integrity as marker of disease progression in preclinical ADAD.</description><subject>Adult</subject><subject>Alzheimer Disease - diagnostic imaging</subject><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer's disease</subject><subject>Amyloid beta-Peptides - metabolism</subject><subject>autosomal dominant</subject><subject>brainstem</subject><subject>Cognitive Dysfunction</subject><subject>early onset</subject><subject>Humans</subject><subject>Locus Coeruleus</subject><subject>Mutation - genetics</subject><subject>Positron-Emission Tomography - methods</subject><subject>Presenilin-1 - genetics</subject><subject>tau</subject><subject>tau Proteins - genetics</subject><subject>tau Proteins - metabolism</subject><issn>1552-5260</issn><issn>1552-5279</issn><issn>1552-5279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9vEzEQxS1ERUvhwBdAe6M9pPWfteO9IEVVC0iRuICQuFgT72xq5LWD7QWlnx4nKRE9cPKT309vZvQIecPoFaOUX4N_uGJcSfWMnDEp-Uzyeff8qBU9JS9z_kFpSzWTL8ipkLzTVIszUr5BcGHd-Gin3NiIafJYlQsF18mVbbNJaLHHnZmKs-CbAlMD1qapahf2gHdhb8FUYo5jVX0cXYBQmoV_uEc3YnqXm95lhIyvyMkAPuPrx_ecfL27_XLzcbb8_OHTzWI5s0JTNZNKo2yt6sVKciuoZR1XK7QDzFume9QKbNsB6I4pMWhRj7ZzrgbBeG-xm4tz8v6Qu5lWI9a_UBJ4s0luhLQ1EZx56gR3b9bxl-lazTrNa8DFY0CKPyfMxYwuW_QeAsYpG65aKjhnYodeHlCbYs4Jh-MYRs2uJVNbMvuWKvv2372O5N9aKnB9AH47j9v_J5nF8vsh8g_1VJ-m</recordid><startdate>202301</startdate><enddate>202301</enddate><creator>Jacobs, Heidi I.L.</creator><creator>Becker, John Alex</creator><creator>Kwong, Kenneth</creator><creator>Munera, Diana</creator><creator>Ramirez‐Gomez, Liliana</creator><creator>Engels‐Domínguez, Nina</creator><creator>Sanchez, Justin S</creator><creator>Vila‐Castelar, Clara</creator><creator>Baena, Ana</creator><creator>Sperling, Reisa A.</creator><creator>Johnson, Keith A.</creator><creator>Lopera, Francisco</creator><creator>Quiroz, Yakeel T.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202301</creationdate><title>Waning locus coeruleus integrity precedes cortical tau accrual in preclinical autosomal dominant Alzheimer's disease</title><author>Jacobs, Heidi I.L. ; Becker, John Alex ; Kwong, Kenneth ; Munera, Diana ; Ramirez‐Gomez, Liliana ; Engels‐Domínguez, Nina ; Sanchez, Justin S ; Vila‐Castelar, Clara ; Baena, Ana ; Sperling, Reisa A. ; Johnson, Keith A. ; Lopera, Francisco ; Quiroz, Yakeel T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3806-568e54c6d3b52c30c1926becfa7418de86ac49aa89163f83279c726f312dce973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adult</topic><topic>Alzheimer Disease - diagnostic imaging</topic><topic>Alzheimer Disease - genetics</topic><topic>Alzheimer's disease</topic><topic>Amyloid beta-Peptides - metabolism</topic><topic>autosomal dominant</topic><topic>brainstem</topic><topic>Cognitive Dysfunction</topic><topic>early onset</topic><topic>Humans</topic><topic>Locus Coeruleus</topic><topic>Mutation - genetics</topic><topic>Positron-Emission Tomography - methods</topic><topic>Presenilin-1 - genetics</topic><topic>tau</topic><topic>tau Proteins - genetics</topic><topic>tau Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jacobs, Heidi I.L.</creatorcontrib><creatorcontrib>Becker, John Alex</creatorcontrib><creatorcontrib>Kwong, Kenneth</creatorcontrib><creatorcontrib>Munera, Diana</creatorcontrib><creatorcontrib>Ramirez‐Gomez, Liliana</creatorcontrib><creatorcontrib>Engels‐Domínguez, Nina</creatorcontrib><creatorcontrib>Sanchez, Justin S</creatorcontrib><creatorcontrib>Vila‐Castelar, Clara</creatorcontrib><creatorcontrib>Baena, Ana</creatorcontrib><creatorcontrib>Sperling, Reisa A.</creatorcontrib><creatorcontrib>Johnson, Keith A.</creatorcontrib><creatorcontrib>Lopera, Francisco</creatorcontrib><creatorcontrib>Quiroz, Yakeel T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Alzheimer's & dementia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jacobs, Heidi I.L.</au><au>Becker, John Alex</au><au>Kwong, Kenneth</au><au>Munera, Diana</au><au>Ramirez‐Gomez, Liliana</au><au>Engels‐Domínguez, Nina</au><au>Sanchez, Justin S</au><au>Vila‐Castelar, Clara</au><au>Baena, Ana</au><au>Sperling, Reisa A.</au><au>Johnson, Keith A.</au><au>Lopera, Francisco</au><au>Quiroz, Yakeel T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Waning locus coeruleus integrity precedes cortical tau accrual in preclinical autosomal dominant Alzheimer's disease</atitle><jtitle>Alzheimer's & dementia</jtitle><addtitle>Alzheimers Dement</addtitle><date>2023-01</date><risdate>2023</risdate><volume>19</volume><issue>1</issue><spage>169</spage><epage>180</epage><pages>169-180</pages><issn>1552-5260</issn><issn>1552-5279</issn><eissn>1552-5279</eissn><abstract>Introduction
Autopsy studies recognize the locus coeruleus (LC) as one of the first sites accumulating tau in Alzheimer's disease (AD). Recent AD work related in vivo LC magnetic resonance imaging (MRI) integrity to tau and cognitive decline; however, relationships of LC integrity to age, tau, and cognition in autosomal dominant AD (ADAD) remain unexplored.
Methods
We associated LC integrity (3T‐MRI) with estimated years of onset, cortical amyloid beta, regional tau (positron emission tomography [PET]) and memory (Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Word‐List‐Learning) among 27 carriers and 27 non‐carriers of the presenilin‐1 (PSEN1) E280A mutation. Longitudinal changes between LC integrity and tau were evaluated in 10 carriers.
Results
LC integrity started to decline at age 32 in carriers, 12 years before clinical onset, and 20 years earlier than in sporadic AD. LC integrity was negatively associated with cortical tau, independent of amyloid beta, and predicted precuneus tau increases. LC integrity was positively associated with memory.
Discussion
These findings support LC integrity as marker of disease progression in preclinical ADAD.</abstract><cop>United States</cop><pmid>35298083</pmid><doi>10.1002/alz.12656</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1552-5260 |
| ispartof | Alzheimer's & dementia, 2023-01, Vol.19 (1), p.169-180 |
| issn | 1552-5260 1552-5279 1552-5279 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9481982 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Alzheimer Disease - diagnostic imaging Alzheimer Disease - genetics Alzheimer's disease Amyloid beta-Peptides - metabolism autosomal dominant brainstem Cognitive Dysfunction early onset Humans Locus Coeruleus Mutation - genetics Positron-Emission Tomography - methods Presenilin-1 - genetics tau tau Proteins - genetics tau Proteins - metabolism |
| title | Waning locus coeruleus integrity precedes cortical tau accrual in preclinical autosomal dominant Alzheimer's disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T05%3A11%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Waning%20locus%20coeruleus%20integrity%20precedes%20cortical%20tau%20accrual%20in%20preclinical%20autosomal%20dominant%20Alzheimer's%20disease&rft.jtitle=Alzheimer's%20&%20dementia&rft.au=Jacobs,%20Heidi%20I.L.&rft.date=2023-01&rft.volume=19&rft.issue=1&rft.spage=169&rft.epage=180&rft.pages=169-180&rft.issn=1552-5260&rft.eissn=1552-5279&rft_id=info:doi/10.1002/alz.12656&rft_dat=%3Cproquest_pubme%3E2640322132%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2640322132&rft_id=info:pmid/35298083&rfr_iscdi=true |