Context-dependent regulation of ferroptosis sensitivity

Ferroptosis is an important mediator of pathophysiological cell death and an emerging target for cancer therapy. Whether ferroptosis sensitivity is governed by a single regulatory mechanism is unclear. Here, based on the integration of 24 published chemical genetic screens combined with targeted fol...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Cell chemical biology 2022-09, Vol.29 (9), p.1409-1418.e6
Hauptverfasser:	Magtanong, Leslie, Mueller, Grace D., Williams, Kevin J., Billmann, Maximilian, Chan, Katherine, Armenta, David A., Pope, Lauren E., Moffat, Jason, Boone, Charles, Myers, Chad L., Olzmann, James A., Bensinger, Steven J., Dixon, Scott J.
Format:	Artikel
Sprache:	eng
Schlagworte:	ACSL4 cancer Cell Line, Tumor Coenzyme A Coenzyme A Ligases - metabolism Cystine ether lipid Ferroptosis iron Lipid Peroxides Phospholipid Hydroperoxide Glutathione Peroxidase PUFA ROS
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!