The effects of AUT00206, a novel Kv3.1/3.2 potassium channel modulator, on task-based reward system activation: a test of mechanism in schizophrenia

The pathophysiology of schizophrenia involves abnormal reward processing, thought to be due to disrupted striatal and dopaminergic function. Consistent with this hypothesis, functional magnetic resonance imaging (fMRI) studies using the monetary incentive delay (MID) task report hypoactivation in th...

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Veröffentlicht in:	Psychopharmacology 2022-10, Vol.239 (10), p.3313-3323
Hauptverfasser:	Kaar, Stephen J., Angelescu, Ilinca, Nour, Matthew M., Marques, Tiago Reis, Sharman, Alice, Sajjala, Anil, Hutchison, John, McGuire, Philip, Large, Charles, Howes, Oliver D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antipsychotic drugs Biomedical and Life Sciences Biomedicine Chemical inhibitors Development and progression Dopamine receptors Drug therapy Functional magnetic resonance imaging Health aspects Humans Interneurons Magnetic Resonance Imaging Mental disorders Neostriatum Neurosciences Original Investigation Pharmacology/Toxicology Potassium Potassium channels Potassium channels (voltage-gated) Psychiatry Reinforcement Reward Reward (Psychology) Schizophrenia Schizophrenia - diagnostic imaging Schizophrenia - drug therapy Shaw Potassium Channels Testing Ventral Striatum - physiology γ-Aminobutyric acid
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