Loss of FGFR4 promotes the malignant phenotype of PDAC

Transcriptomic analyses of pancreatic ductal adenocarcinoma (PDAC) have identified two major epithelial subtypes with distinct biology and clinical behaviours. Here, we aimed to clarify the role of FGFR1 and FGFR4 in the definition of aggressive PDAC phenotypes. We found that the expression of FGFR4...

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Veröffentlicht in:	Oncogene 2022-09, Vol.41 (38), p.4371-4384
Hauptverfasser:	D’Agosto, Sabrina, Pezzini, Francesco, Veghini, Lisa, Delfino, Pietro, Fiorini, Claudia, Temgue Tane, Gael D., Del Curatolo, Anais, Vicentini, Caterina, Ferrari, Giorgia, Pasini, Davide, Andreani, Silvia, Lupo, Francesca, Fiorini, Elena, Lorenzon, Giulia, Lawlor, Rita T., Rusev, Borislav, Malinova, Antonia, Luchini, Claudio, Milella, Michele, Sereni, Elisabetta, Pea, Antonio, Bassi, Claudio, Bailey, Peter, Scarpa, Aldo, Bria, Emilio, Corbo, Vincenzo
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 14/32 38/89 38/91 631/67/1504/1713 631/80/83/2359 82/51 Adenocarcinoma Apoptosis Carcinoma, Pancreatic Ductal - pathology Carcinoma, Squamous Cell Cell Biology Cell lineage Cell proliferation Epithelial cells Fibroblast growth factor receptor 1 Fibroblast growth factor receptor 4 Genotype & phenotype Histones Human Genetics Humans Internal Medicine Mechanistic Target of Rapamycin Complex 1 - genetics Medicine Medicine & Public Health Oncology Pancreas Pancreatic cancer Pancreatic Neoplasms Pancreatic Neoplasms - pathology Phenotype Phenotypes Receptor, Fibroblast Growth Factor, Type 4 - genetics Regulatory sequences Transcriptomics
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