Imaging sensitive and drug-resistant bacterial infection with [11C]-trimethoprim

BACKGROUND. Several molecular imaging strategies can identify bacterial infections in humans. PET affords the potential for sensitive infection detection deep within the body. Among PET-based approaches, antibiotic-based radiotracers, which often target key bacterial-specific enzymes, have considera...

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Veröffentlicht in:	The Journal of clinical investigation 2022-09, Vol.132 (18), p.1-12
Hauptverfasser:	Lee, Iris K., Jacome, Daniel A., Cho, Joshua K., Tu, Vincent, Young, Anthony J., Dominguez, Tiffany, Northrup, Justin D., Etersque, Jean M., Lee, Hsiaoju S., Ruff, Andrew, Aklilu, Ouniol, Bittinger, Kyle, Glaser, Laurel J., Dorgan, Daniel, Hadjiliadis, Denis, Kohli, Rahul M., Mach, Robert H., Mankoff, David A., Doot, Robert K., Sellmyer, Mark A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Antimicrobial agents Antimicrobial resistance Bacteria Bacterial infections Binding sites Biomedical research Clinical Medicine Dihydrofolate reductase Drug dosages Drug resistance E coli Enzymes Feasibility studies Genes Genomes Infections Metabolism Patients Quality control Strains (organisms) Trimethoprim Whole genome sequencing
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