Changes in regeneration-responsive enhancers shape regenerative capacities in vertebrates

Vertebrates vary in their ability to regenerate, and the genetic mechanisms underlying such disparity remain elusive. Comparative epigenomic profiling and single-cell sequencing of two related teleost fish uncovered species-specific and evolutionarily conserved genomic responses to regeneration. The...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2020-09, Vol.369 (6508)
Hauptverfasser:	Wang, Wei, Hu, Chi-Kuo, Zeng, An, Alegre, Dana, Hu, Deqing, Gotting, Kirsten, Ortega Granillo, Augusto, Wang, Yongfu, Robb, Sofia, Schnittker, Robert, Zhang, Shasha, Alegre, Dillon, Li, Hua, Ross, Eric, Zhang, Ning, Brunet, Anne, Sánchez Alvarado, Alejandro
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Activator protein 1 Amino Acid Motifs Amputation Animals Appendages Binding Biological evolution Chromatin Context Danio rerio Deletion Enhancer Elements, Genetic - physiology Enhancers Epigenesis, Genetic Evolution Evolution, Molecular Feedback (Response) Fish Fruit flies Functional testing Gene expression Gene Expression Profiling Gene sequencing Genetics Genomes Genomics Heart Histones - metabolism Immunoprecipitation Inhibin Inhibin-beta Subunits - genetics Injuries Killifishes - genetics Killifishes - physiology Life history Mammals Molecular modelling Organs Phylogeny Physical Disabilities Proteins Regeneration Regeneration - genetics Regenerators Regulatory sequences Ribonucleic acid RNA RNA-Seq Single-Cell Analysis Speciation Species Spinal cord Transcription Factor AP-1 - chemistry Transcription Factor AP-1 - metabolism Transcription factors Transcriptional Activation Transgenic fish Vertebrates Zebrafish Zebrafish - genetics Zebrafish - physiology
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