Decreased cognitive function is associated with preceding severe hypoglycemia and impaired blood glucose control in the elderly individuals with type 1 diabetes
Aim/Introduction This investigation aimed to clarify the relationship between cognitive function and blood glucose control in the elderly individuals with type 1 diabetes. Materials and methods In total, 45 patients with type 1 diabetes, age 74.9 ± 6.7 years, and HbA1c levels of 7.9 ± 0.9% were stud...
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| Veröffentlicht in: | Diabetology International 2022-10, Vol.13 (4), p.679-686 |
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| creator | Shigemoto, Shou Imbe, Hisashi Fujisawa, Reiko Sasagawa, Akiko Watanabe, Daisuke Tachibana, Megumi Sano, Hiroyuki Kanatsuna, Norio Terasaki, Jungo Imagawa, Akihisa |
| description | Aim/Introduction
This investigation aimed to clarify the relationship between cognitive function and blood glucose control in the elderly individuals with type 1 diabetes.
Materials and methods
In total, 45 patients with type 1 diabetes, age 74.9 ± 6.7 years, and HbA1c levels of 7.9 ± 0.9% were studied. Severe hypoglycemia occurred in 33% of patients, and the number of severe hypoglycemia episodes was 0.6 ± 1.2 in the past 5 years before the time of the cognitive function tests. We analyzed clinical data and dementia scores on the Revised Hasegawa’s Dementia Scale (HDS-R), Mini-Mental State Examination (MMSE), and Dementia Assessment Sheet for Community-based Integrated Care System, and 21 items (DASC-21).
Results
There was a significant correlation between HbA1c and HDS-R, MMSE, respectively. There was a significant correlation between the number of severe hypoglycemic episodes and HDS-R, MMSE, and DASC-21, respectively. When the group with experience of severe hypoglycemia was compared to the control group, HDS-R, MMSE, and DASC-21 were meaningfully different after adjusting for age modeling analysis of covariance.
Conclusions
In elderly individuals with type 1 diabetes, our results suggest that high HbA1c for the past 5 years from the cognitive function test and a history of severe hypoglycemic episodes from the time of disease diagnosis are related to decreased cognitive function. |
| doi_str_mv | 10.1007/s13340-022-00588-9 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9478001</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A717928393</galeid><sourcerecordid>A717928393</sourcerecordid><originalsourceid>FETCH-LOGICAL-c599t-c1fb031bcdb57cce4081d8ba7d9d103675490d64e47e2a91ef387346b7ef79ea3</originalsourceid><addsrcrecordid>eNp9kstu3CAUhq2qVROleYEuKqRuunEKxmNgUylKr1Kkbto1wnDsIWLABXuieZs-as_U6fSyKCy4nO_8HOCvqueMXjFKxevCOG9pTZumpnQjZa0eVecNU7Rmnewen-ZCnlWXpdxRbK1iVHRPqzPeMSZUQ8-r72_BZjAFHLFpjH72eyDDEu3sUyS-EFNKst7MCNz7eUumDBacjyMpsIcMZHuY0hgOFnbeEBMd8bvJ-Ix8H1JyZAyLTQVQPs45BeIjmbdAIDjI4YBL5_feLSaU9YD5MAFhxHnTwwzlWfVkwBhcPowX1df3777cfKxvP3_4dHN9W9uNUnNt2dBTznrr-o2wFloqmZO9EU45RnknNq2irmuhFdAYxWDgUvC26wUMQoHhF9WbVXda-h04C1itCXrKfmfyQSfj9d-R6Ld6THutWiEpZSjw6kEgp28LlFnvfLEQgomQlqIbwTZCKkkFoi__Qe_SkiNe70jhL7FOHamrlRpNAO3jkPBci93hU-NrwuBx_1ocf1JyxTGhWRNsTqVkGE7VM6qPptGraTSaRv80jVaY9OLPe59SflkEAb4CBUNxhPy72P_I_gB8VNEj</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2714911697</pqid></control><display><type>article</type><title>Decreased cognitive function is associated with preceding severe hypoglycemia and impaired blood glucose control in the elderly individuals with type 1 diabetes</title><source>Springer Nature - Complete Springer Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Shigemoto, Shou ; Imbe, Hisashi ; Fujisawa, Reiko ; Sasagawa, Akiko ; Watanabe, Daisuke ; Tachibana, Megumi ; Sano, Hiroyuki ; Kanatsuna, Norio ; Terasaki, Jungo ; Imagawa, Akihisa</creator><creatorcontrib>Shigemoto, Shou ; Imbe, Hisashi ; Fujisawa, Reiko ; Sasagawa, Akiko ; Watanabe, Daisuke ; Tachibana, Megumi ; Sano, Hiroyuki ; Kanatsuna, Norio ; Terasaki, Jungo ; Imagawa, Akihisa</creatorcontrib><description>Aim/Introduction
This investigation aimed to clarify the relationship between cognitive function and blood glucose control in the elderly individuals with type 1 diabetes.
Materials and methods
In total, 45 patients with type 1 diabetes, age 74.9 ± 6.7 years, and HbA1c levels of 7.9 ± 0.9% were studied. Severe hypoglycemia occurred in 33% of patients, and the number of severe hypoglycemia episodes was 0.6 ± 1.2 in the past 5 years before the time of the cognitive function tests. We analyzed clinical data and dementia scores on the Revised Hasegawa’s Dementia Scale (HDS-R), Mini-Mental State Examination (MMSE), and Dementia Assessment Sheet for Community-based Integrated Care System, and 21 items (DASC-21).
Results
There was a significant correlation between HbA1c and HDS-R, MMSE, respectively. There was a significant correlation between the number of severe hypoglycemic episodes and HDS-R, MMSE, and DASC-21, respectively. When the group with experience of severe hypoglycemia was compared to the control group, HDS-R, MMSE, and DASC-21 were meaningfully different after adjusting for age modeling analysis of covariance.
Conclusions
In elderly individuals with type 1 diabetes, our results suggest that high HbA1c for the past 5 years from the cognitive function test and a history of severe hypoglycemic episodes from the time of disease diagnosis are related to decreased cognitive function.</description><identifier>ISSN: 2190-1678</identifier><identifier>EISSN: 2190-1686</identifier><identifier>DOI: 10.1007/s13340-022-00588-9</identifier><identifier>PMID: 36117920</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Analysis ; Blood sugar ; Cognitive ability ; Dementia ; Dementia disorders ; Diabetes ; Diabetes mellitus (insulin dependent) ; Diabetes therapy ; Endocrinology ; Glycosylated hemoglobin ; Hydrogen sulfide ; Hypoglycemia ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Original ; Original Article ; Patients ; Type 1 diabetes ; Type 2 diabetes</subject><ispartof>Diabetology International, 2022-10, Vol.13 (4), p.679-686</ispartof><rights>The Japan Diabetes Society 2022</rights><rights>The Japan Diabetes Society 2022.</rights><rights>COPYRIGHT 2022 Springer</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c599t-c1fb031bcdb57cce4081d8ba7d9d103675490d64e47e2a91ef387346b7ef79ea3</citedby><cites>FETCH-LOGICAL-c599t-c1fb031bcdb57cce4081d8ba7d9d103675490d64e47e2a91ef387346b7ef79ea3</cites><orcidid>0000-0002-1719-2497</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478001/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478001/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36117920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shigemoto, Shou</creatorcontrib><creatorcontrib>Imbe, Hisashi</creatorcontrib><creatorcontrib>Fujisawa, Reiko</creatorcontrib><creatorcontrib>Sasagawa, Akiko</creatorcontrib><creatorcontrib>Watanabe, Daisuke</creatorcontrib><creatorcontrib>Tachibana, Megumi</creatorcontrib><creatorcontrib>Sano, Hiroyuki</creatorcontrib><creatorcontrib>Kanatsuna, Norio</creatorcontrib><creatorcontrib>Terasaki, Jungo</creatorcontrib><creatorcontrib>Imagawa, Akihisa</creatorcontrib><title>Decreased cognitive function is associated with preceding severe hypoglycemia and impaired blood glucose control in the elderly individuals with type 1 diabetes</title><title>Diabetology International</title><addtitle>Diabetol Int</addtitle><addtitle>Diabetol Int</addtitle><description>Aim/Introduction
This investigation aimed to clarify the relationship between cognitive function and blood glucose control in the elderly individuals with type 1 diabetes.
Materials and methods
In total, 45 patients with type 1 diabetes, age 74.9 ± 6.7 years, and HbA1c levels of 7.9 ± 0.9% were studied. Severe hypoglycemia occurred in 33% of patients, and the number of severe hypoglycemia episodes was 0.6 ± 1.2 in the past 5 years before the time of the cognitive function tests. We analyzed clinical data and dementia scores on the Revised Hasegawa’s Dementia Scale (HDS-R), Mini-Mental State Examination (MMSE), and Dementia Assessment Sheet for Community-based Integrated Care System, and 21 items (DASC-21).
Results
There was a significant correlation between HbA1c and HDS-R, MMSE, respectively. There was a significant correlation between the number of severe hypoglycemic episodes and HDS-R, MMSE, and DASC-21, respectively. When the group with experience of severe hypoglycemia was compared to the control group, HDS-R, MMSE, and DASC-21 were meaningfully different after adjusting for age modeling analysis of covariance.
Conclusions
In elderly individuals with type 1 diabetes, our results suggest that high HbA1c for the past 5 years from the cognitive function test and a history of severe hypoglycemic episodes from the time of disease diagnosis are related to decreased cognitive function.</description><subject>Analysis</subject><subject>Blood sugar</subject><subject>Cognitive ability</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>Diabetes</subject><subject>Diabetes mellitus (insulin dependent)</subject><subject>Diabetes therapy</subject><subject>Endocrinology</subject><subject>Glycosylated hemoglobin</subject><subject>Hydrogen sulfide</subject><subject>Hypoglycemia</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Original</subject><subject>Original Article</subject><subject>Patients</subject><subject>Type 1 diabetes</subject><subject>Type 2 diabetes</subject><issn>2190-1678</issn><issn>2190-1686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kstu3CAUhq2qVROleYEuKqRuunEKxmNgUylKr1Kkbto1wnDsIWLABXuieZs-as_U6fSyKCy4nO_8HOCvqueMXjFKxevCOG9pTZumpnQjZa0eVecNU7Rmnewen-ZCnlWXpdxRbK1iVHRPqzPeMSZUQ8-r72_BZjAFHLFpjH72eyDDEu3sUyS-EFNKst7MCNz7eUumDBacjyMpsIcMZHuY0hgOFnbeEBMd8bvJ-Ix8H1JyZAyLTQVQPs45BeIjmbdAIDjI4YBL5_feLSaU9YD5MAFhxHnTwwzlWfVkwBhcPowX1df3777cfKxvP3_4dHN9W9uNUnNt2dBTznrr-o2wFloqmZO9EU45RnknNq2irmuhFdAYxWDgUvC26wUMQoHhF9WbVXda-h04C1itCXrKfmfyQSfj9d-R6Ld6THutWiEpZSjw6kEgp28LlFnvfLEQgomQlqIbwTZCKkkFoi__Qe_SkiNe70jhL7FOHamrlRpNAO3jkPBci93hU-NrwuBx_1ocf1JyxTGhWRNsTqVkGE7VM6qPptGraTSaRv80jVaY9OLPe59SflkEAb4CBUNxhPy72P_I_gB8VNEj</recordid><startdate>20221001</startdate><enddate>20221001</enddate><creator>Shigemoto, Shou</creator><creator>Imbe, Hisashi</creator><creator>Fujisawa, Reiko</creator><creator>Sasagawa, Akiko</creator><creator>Watanabe, Daisuke</creator><creator>Tachibana, Megumi</creator><creator>Sano, Hiroyuki</creator><creator>Kanatsuna, Norio</creator><creator>Terasaki, Jungo</creator><creator>Imagawa, Akihisa</creator><general>Springer Nature Singapore</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1719-2497</orcidid></search><sort><creationdate>20221001</creationdate><title>Decreased cognitive function is associated with preceding severe hypoglycemia and impaired blood glucose control in the elderly individuals with type 1 diabetes</title><author>Shigemoto, Shou ; Imbe, Hisashi ; Fujisawa, Reiko ; Sasagawa, Akiko ; Watanabe, Daisuke ; Tachibana, Megumi ; Sano, Hiroyuki ; Kanatsuna, Norio ; Terasaki, Jungo ; Imagawa, Akihisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c599t-c1fb031bcdb57cce4081d8ba7d9d103675490d64e47e2a91ef387346b7ef79ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Analysis</topic><topic>Blood sugar</topic><topic>Cognitive ability</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>Diabetes</topic><topic>Diabetes mellitus (insulin dependent)</topic><topic>Diabetes therapy</topic><topic>Endocrinology</topic><topic>Glycosylated hemoglobin</topic><topic>Hydrogen sulfide</topic><topic>Hypoglycemia</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Original</topic><topic>Original Article</topic><topic>Patients</topic><topic>Type 1 diabetes</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shigemoto, Shou</creatorcontrib><creatorcontrib>Imbe, Hisashi</creatorcontrib><creatorcontrib>Fujisawa, Reiko</creatorcontrib><creatorcontrib>Sasagawa, Akiko</creatorcontrib><creatorcontrib>Watanabe, Daisuke</creatorcontrib><creatorcontrib>Tachibana, Megumi</creatorcontrib><creatorcontrib>Sano, Hiroyuki</creatorcontrib><creatorcontrib>Kanatsuna, Norio</creatorcontrib><creatorcontrib>Terasaki, Jungo</creatorcontrib><creatorcontrib>Imagawa, Akihisa</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diabetology International</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shigemoto, Shou</au><au>Imbe, Hisashi</au><au>Fujisawa, Reiko</au><au>Sasagawa, Akiko</au><au>Watanabe, Daisuke</au><au>Tachibana, Megumi</au><au>Sano, Hiroyuki</au><au>Kanatsuna, Norio</au><au>Terasaki, Jungo</au><au>Imagawa, Akihisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased cognitive function is associated with preceding severe hypoglycemia and impaired blood glucose control in the elderly individuals with type 1 diabetes</atitle><jtitle>Diabetology International</jtitle><stitle>Diabetol Int</stitle><addtitle>Diabetol Int</addtitle><date>2022-10-01</date><risdate>2022</risdate><volume>13</volume><issue>4</issue><spage>679</spage><epage>686</epage><pages>679-686</pages><issn>2190-1678</issn><eissn>2190-1686</eissn><abstract>Aim/Introduction
This investigation aimed to clarify the relationship between cognitive function and blood glucose control in the elderly individuals with type 1 diabetes.
Materials and methods
In total, 45 patients with type 1 diabetes, age 74.9 ± 6.7 years, and HbA1c levels of 7.9 ± 0.9% were studied. Severe hypoglycemia occurred in 33% of patients, and the number of severe hypoglycemia episodes was 0.6 ± 1.2 in the past 5 years before the time of the cognitive function tests. We analyzed clinical data and dementia scores on the Revised Hasegawa’s Dementia Scale (HDS-R), Mini-Mental State Examination (MMSE), and Dementia Assessment Sheet for Community-based Integrated Care System, and 21 items (DASC-21).
Results
There was a significant correlation between HbA1c and HDS-R, MMSE, respectively. There was a significant correlation between the number of severe hypoglycemic episodes and HDS-R, MMSE, and DASC-21, respectively. When the group with experience of severe hypoglycemia was compared to the control group, HDS-R, MMSE, and DASC-21 were meaningfully different after adjusting for age modeling analysis of covariance.
Conclusions
In elderly individuals with type 1 diabetes, our results suggest that high HbA1c for the past 5 years from the cognitive function test and a history of severe hypoglycemic episodes from the time of disease diagnosis are related to decreased cognitive function.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><pmid>36117920</pmid><doi>10.1007/s13340-022-00588-9</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-1719-2497</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Springer Nature - Complete Springer Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Analysis Blood sugar Cognitive ability Dementia Dementia disorders Diabetes Diabetes mellitus (insulin dependent) Diabetes therapy Endocrinology Glycosylated hemoglobin Hydrogen sulfide Hypoglycemia Medicine Medicine & Public Health Metabolic Diseases Original Original Article Patients Type 1 diabetes Type 2 diabetes |
| title | Decreased cognitive function is associated with preceding severe hypoglycemia and impaired blood glucose control in the elderly individuals with type 1 diabetes |
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