Febuxostat Alleviates Allergic Rhinitis by Inhibiting Inflammation and Monocyte Adhesion in Human Nasal Epithelial Cells via Regulating KLF6

Introduction. Febuxostat is a novel inhibitor of xanthine oxidase that suppresses cell adhesion molecules-mediated (CAMs) inflammation by activating KLF6. In this study, we explored the therapeutic function and potential mechanisms of febuxostat against allergic rhinitis (AR). Methods. We investigat...

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Veröffentlicht in:	Evidence-based complementary and alternative medicine 2022-09, Vol.2022, p.1-10
Hauptverfasser:	Yao, Yuting, Wei, Ran, Jiang, Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergic rhinitis Animal models Animal research Cell adhesion molecules Chemokines Cytokines Epithelial cells Hay fever Histamine Inflammation Ischemia L-Lactate dehydrogenase Laboratory animals Lactic acid Monocytes Nose Ovalbumin Proteins Rhinitis Software Statistical analysis Tumor necrosis factor-TNF Xanthine oxidase
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