Ganoderic acid D prevents oxidative stress‐induced senescence by targeting 14‐3‐3ε to activate CaM/CaMKII/NRF2 signaling pathway in mesenchymal stem cells

Stem cell senescence is an important cause of aging. Delaying senescence may present a novel way to combat aging and age‐associated diseases. This study provided a mechanistic insight into the protective effect of ganoderic acid D (GA‐D) against human amniotic mesenchymal stem cell (hAMSCs) senescen...

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Veröffentlicht in:	Aging cell 2022-09, Vol.21 (9), p.e13686-n/a
Hauptverfasser:	Yuan, Huan, Xu, Yan, Luo, Yi, Zhang, Jia‐Rong, Zhu, Xin‐Xin, Xiao, Jian‐Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins - metabolism 14‐3‐3ε Advanced glycosylation end products Aging aging mouse model Alzheimer's disease Animals Antioxidants - pharmacology anti‐aging Apoptosis Bone marrow bone‐marrow mesenchymal stem cells Ca2+/calmodulin-dependent protein kinase II Calcium-binding protein Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Calmodulin CaM/CaMKII/Nrf2 signaling Cancer Cell cycle Cell differentiation Cell Proliferation Cell viability Cellular Senescence - genetics Galactose Ganoderic acid ganoderic acid D Glutathione peroxidase Glycation End Products, Advanced - metabolism Glycosylation Homeostasis human amniotic mesenchymal stem cells Humans Kinases Mesenchymal stem cells Mesenchymal Stem Cells - metabolism Mice Neurogenesis NF-E2-Related Factor 2 - metabolism Organisms Oxidative Stress Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Senescence Signal Transduction Stem cell transplantation Stem cells Superoxide dismutase Triterpenes - pharmacology
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