Discovery and validation of a transcriptional signature identifying homologous recombination-deficient breast, endometrial and ovarian cancers

Background Molecular alterations leading to homologous recombination deficiency (HRD) are heterogeneous. We aimed to identify a transcriptional profile shared by endometrial (UCEC), breast (BRCA) and ovarian (OV) cancers with HRD. Methods Genes differentially expressed with HRD genomic score (contin...

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Veröffentlicht in:	British journal of cancer 2022-10, Vol.127 (6), p.1123-1132
Hauptverfasser:	Beinse, Guillaume, Just, Pierre-Alexandre, Le Frere Belda, Marie-Aude, Laurent-Puig, Pierre, Jacques, Sebastien, Koual, Meriem, Garinet, Simon, Leroy, Karen, Delanoy, Nicolas, Blons, Helene, Gervais, Claire, Durdux, Catherine, Chapron, Charles, Goldwasser, François, Terris, Benoit, Badoual, Cecile, Taly, Valerie, Bats, Anne-Sophie, Borghese, Bruno, Alexandre, Jérôme
Format:	Artikel
Sprache:	eng
Schlagworte:	631/114/2413 692/308/575 692/4028/67/1517 692/53/2422 692/53/2423 Biomedical and Life Sciences Biomedicine BRCA1 Protein - genetics BRCA2 Protein - genetics Breast Breast cancer Cancer Cancer Research Chemotherapy Chromatin Cytoskeleton DNA Repair Drug Resistance Endometrial cancer Endometrium Epidemiology Female Genomics Gynecology Homologous recombination Homologous Recombination - genetics Humans Life Sciences Molecular Medicine Oncology Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovaries p53 Protein Transcription
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