HLA-independent T cell receptors for targeting tumors with low antigen density

Chimeric antigen receptors (CARs) are receptors for antigen that direct potent immune responses. Tumor escape associated with low target antigen expression is emerging as one potential limitation of their efficacy. Here we edit the TRAC locus in human peripheral blood T cells to engage cell-surface...

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Veröffentlicht in:	Nature medicine 2022-02, Vol.28 (2), p.345-352
Hauptverfasser:	Mansilla-Soto, Jorge, Eyquem, Justin, Haubner, Sascha, Hamieh, Mohamad, Feucht, Judith, Paillon, Noémie, Zucchetti, Andrés Ernesto, Li, Zhuoning, Sjöstrand, Maria, Lindenbergh, Pieter L., Saetersmoen, Michelle, Dobrin, Anton, Maurin, Mathieu, Iyer, Archana, Garcia Angus, Andreina, Miele, Matthew M., Zhao, Zeguo, Giavridis, Theodoros, van der Stegen, Sjoukje J. C., Tamzalit, Fella, Rivière, Isabelle, Huse, Morgan, Hendrickson, Ronald C., Hivroz, Claire, Sadelain, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/554 631/250/2520 631/67/1059/2325 692/699/67/1990/283 Acute myeloid leukemia Animal models Animals Antigens Antigens, CD19 Automobiles Biomedical and Life Sciences Biomedicine Cancer Research CD19 antigen CD28 antigen CD3 antigen CD70 antigen CD80 antigen Cell culture Cell surface Chains Chimeric antigen receptors Histocompatibility antigen HLA Histocompatibility Antigens Humans Immunotherapy, Adoptive Infectious Diseases Leukemia Leukemia, Myeloid, Acute Light chains Loci Lymphocytes Lymphocytes T Metabolic Diseases Mice Molecular Medicine Neurosciences Peripheral blood Receptors Receptors, Antigen, T-Cell Receptors, Chimeric Antigen - metabolism Sensitivity Surface antigens T cell receptors Tumors Xenograft Model Antitumor Assays Xenografts Xenotransplantation
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