Interrogating the substrate specificity landscape of UvrC reveals novel insights into its non-canonical function

Although it is relatively unexplored, accumulating data highlight the importance of tripartite crosstalk between nucleotide excision repair (NER), DNA replication, and recombination in the maintenance of genome stability; however, elucidating the underlying mechanisms remains challenging. While Esch...

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Veröffentlicht in:	Biophysical journal 2022-08, Vol.121 (16), p.3103-3125
Hauptverfasser:	Thakur, Manoj, Parulekar, Rishikesh S., Barale, Sagar S., Sonawane, Kailas D., Muniyappa, Kalappa
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA Damage DNA Repair Endodeoxyribonucleases - genetics Endodeoxyribonucleases - metabolism Escherichia coli - enzymology Escherichia coli - genetics Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Molecular Docking Simulation Substrate Specificity
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