In vivo evaluation of anticryptosporidial effects of wheat germ extracts in immunocompromised mice
Cryptosporidium species is a prime cause of diarrheal disease in individuals with competent immunity. In patients with compromised immunity, infections are more severe particularly in developing countries. Wheat germ oil was described to have antiparasitic effect. This study was done to evaluate the...
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| Veröffentlicht in: | Journal of parasitic diseases 2022, Vol.46 (3), p.833-844 |
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| creator | Abdelmaksoud, Hagar F. Osman, Ezzat E. A. Abdel-Hameed, Sayed S. Aboushousha, Tarek Naggar, Heba M. El |
| description | Cryptosporidium
species is a prime cause of diarrheal disease in individuals with competent immunity. In patients with compromised immunity, infections are more severe particularly in developing countries. Wheat germ oil was described to have antiparasitic effect. This study was done to evaluate the possible role of wheat germ extracts in
Cryptosporidium parvum (C. parvum)
infected immunocompromised mice. Thirty white albino mice were classified into six groups as follow: four study groups, all immunosuppressed and infected with
C. parvum
oocysts. These four groups received treatments as follow:
Group (I):
treated with nitazoxanide.
Group (II):
treated with wheat germ oil.
Group (III):
treated with wheat germ extracted by hexane.
Group (IV):
treated with wheat germ extracted by ethanol. The remaining two groups were immunosuppressed control groups as follow:
Group (V):
only infected with
C. parvum
oocysts (Positive control).
Group (VI):
non-infected (Negative control). Stool samples were collected and examined to detect oocyst and the ileocecal region was subjected to histopathological and immunohistochemical examination. Wheat germ extracts showed a statistically significant effect against
C. parvum
specially wheat germ oil with
P
value: |
| doi_str_mv | 10.1007/s12639-022-01502-5 |
| format | Article |
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species is a prime cause of diarrheal disease in individuals with competent immunity. In patients with compromised immunity, infections are more severe particularly in developing countries. Wheat germ oil was described to have antiparasitic effect. This study was done to evaluate the possible role of wheat germ extracts in
Cryptosporidium parvum (C. parvum)
infected immunocompromised mice. Thirty white albino mice were classified into six groups as follow: four study groups, all immunosuppressed and infected with
C. parvum
oocysts. These four groups received treatments as follow:
Group (I):
treated with nitazoxanide.
Group (II):
treated with wheat germ oil.
Group (III):
treated with wheat germ extracted by hexane.
Group (IV):
treated with wheat germ extracted by ethanol. The remaining two groups were immunosuppressed control groups as follow:
Group (V):
only infected with
C. parvum
oocysts (Positive control).
Group (VI):
non-infected (Negative control). Stool samples were collected and examined to detect oocyst and the ileocecal region was subjected to histopathological and immunohistochemical examination. Wheat germ extracts showed a statistically significant effect against
C. parvum
specially wheat germ oil with
P
value: < 0.001, this effect was also confirmed by pathological and immunohistochemical examinations.
C. parvum
has an influence on human health by its effect in diarrheal disease. Wheat germ oil and its extracts has proved to be a reliable herb for
C. parvum.
treatment confirmed by different methodologies.</description><identifier>ISSN: 0971-7196</identifier><identifier>EISSN: 0975-0703</identifier><identifier>DOI: 10.1007/s12639-022-01502-5</identifier><identifier>PMID: 36091283</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Antiparasitic agents ; Developing countries ; Diarrhea ; Ethanol ; Health Promotion and Disease Prevention ; Infectious Diseases ; LDCs ; Medicine ; Medicine & Public Health ; Oocysts ; Original ; Original Article ; Protozoa ; Statistical analysis ; Wheat germ</subject><ispartof>Journal of parasitic diseases, 2022, Vol.46 (3), p.833-844</ispartof><rights>Indian Society for Parasitology 2022</rights><rights>Indian Society for Parasitology 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2735-a263d512df648269619be97218c3525db6759db2337f6f308aca933265b055d23</cites><orcidid>0000-0003-0394-494X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458818/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458818/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids></links><search><creatorcontrib>Abdelmaksoud, Hagar F.</creatorcontrib><creatorcontrib>Osman, Ezzat E. A.</creatorcontrib><creatorcontrib>Abdel-Hameed, Sayed S.</creatorcontrib><creatorcontrib>Aboushousha, Tarek</creatorcontrib><creatorcontrib>Naggar, Heba M. El</creatorcontrib><title>In vivo evaluation of anticryptosporidial effects of wheat germ extracts in immunocompromised mice</title><title>Journal of parasitic diseases</title><addtitle>J Parasit Dis</addtitle><description>Cryptosporidium
species is a prime cause of diarrheal disease in individuals with competent immunity. In patients with compromised immunity, infections are more severe particularly in developing countries. Wheat germ oil was described to have antiparasitic effect. This study was done to evaluate the possible role of wheat germ extracts in
Cryptosporidium parvum (C. parvum)
infected immunocompromised mice. Thirty white albino mice were classified into six groups as follow: four study groups, all immunosuppressed and infected with
C. parvum
oocysts. These four groups received treatments as follow:
Group (I):
treated with nitazoxanide.
Group (II):
treated with wheat germ oil.
Group (III):
treated with wheat germ extracted by hexane.
Group (IV):
treated with wheat germ extracted by ethanol. The remaining two groups were immunosuppressed control groups as follow:
Group (V):
only infected with
C. parvum
oocysts (Positive control).
Group (VI):
non-infected (Negative control). Stool samples were collected and examined to detect oocyst and the ileocecal region was subjected to histopathological and immunohistochemical examination. Wheat germ extracts showed a statistically significant effect against
C. parvum
specially wheat germ oil with
P
value: < 0.001, this effect was also confirmed by pathological and immunohistochemical examinations.
C. parvum
has an influence on human health by its effect in diarrheal disease. Wheat germ oil and its extracts has proved to be a reliable herb for
C. parvum.
treatment confirmed by different methodologies.</description><subject>Antiparasitic agents</subject><subject>Developing countries</subject><subject>Diarrhea</subject><subject>Ethanol</subject><subject>Health Promotion and Disease Prevention</subject><subject>Infectious Diseases</subject><subject>LDCs</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oocysts</subject><subject>Original</subject><subject>Original Article</subject><subject>Protozoa</subject><subject>Statistical analysis</subject><subject>Wheat germ</subject><issn>0971-7196</issn><issn>0975-0703</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kc1O3TAQha0KVCjwAl1Z6oZN2rGN_zZIFaItEhIbWFuO44BRYgc7ueW-fR0uKiqLrmzNfHM0Zw5Cnwl8JQDyWyFUMN0ApQ0QDrThH9AhaMkbkMD2Xv6kkUSLA_SplEcAXuvqIzpgAjShih2i9iriTdgk7Dd2WOwcUsSpxzbOweXtNKcypRy6YAfs-967uazt3w_ezvje5xH75znbtRwiDuO4xOTSOOU0huI7PAbnj9F-b4fiT17fI3T34_L24ldzffPz6uL7deOoZLyx1UzHCe16caao0ILo1mtJiXKMU961QnLdtZQx2YuegbLOasao4C1w3lF2hM53utPSjr5zPtbNBjPlMNq8NckG828nhgdznzZGn3GliKoCp68COT0tvsymmnB-GGz0aSmGSsIYaMFX9Ms79DEtOVZ7K0WUBqlWiu4ol1Mp2fd_lyFg1gjNLkJTIzQvERpeh9huqFQ41hu_Sf9n6g_6mJ4j</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Abdelmaksoud, Hagar F.</creator><creator>Osman, Ezzat E. A.</creator><creator>Abdel-Hameed, Sayed S.</creator><creator>Aboushousha, Tarek</creator><creator>Naggar, Heba M. El</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0394-494X</orcidid></search><sort><creationdate>2022</creationdate><title>In vivo evaluation of anticryptosporidial effects of wheat germ extracts in immunocompromised mice</title><author>Abdelmaksoud, Hagar F. ; Osman, Ezzat E. A. ; Abdel-Hameed, Sayed S. ; Aboushousha, Tarek ; Naggar, Heba M. El</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2735-a263d512df648269619be97218c3525db6759db2337f6f308aca933265b055d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antiparasitic agents</topic><topic>Developing countries</topic><topic>Diarrhea</topic><topic>Ethanol</topic><topic>Health Promotion and Disease Prevention</topic><topic>Infectious Diseases</topic><topic>LDCs</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oocysts</topic><topic>Original</topic><topic>Original Article</topic><topic>Protozoa</topic><topic>Statistical analysis</topic><topic>Wheat germ</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdelmaksoud, Hagar F.</creatorcontrib><creatorcontrib>Osman, Ezzat E. A.</creatorcontrib><creatorcontrib>Abdel-Hameed, Sayed S.</creatorcontrib><creatorcontrib>Aboushousha, Tarek</creatorcontrib><creatorcontrib>Naggar, Heba M. El</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of parasitic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdelmaksoud, Hagar F.</au><au>Osman, Ezzat E. A.</au><au>Abdel-Hameed, Sayed S.</au><au>Aboushousha, Tarek</au><au>Naggar, Heba M. El</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo evaluation of anticryptosporidial effects of wheat germ extracts in immunocompromised mice</atitle><jtitle>Journal of parasitic diseases</jtitle><stitle>J Parasit Dis</stitle><date>2022</date><risdate>2022</risdate><volume>46</volume><issue>3</issue><spage>833</spage><epage>844</epage><pages>833-844</pages><issn>0971-7196</issn><eissn>0975-0703</eissn><abstract>Cryptosporidium
species is a prime cause of diarrheal disease in individuals with competent immunity. In patients with compromised immunity, infections are more severe particularly in developing countries. Wheat germ oil was described to have antiparasitic effect. This study was done to evaluate the possible role of wheat germ extracts in
Cryptosporidium parvum (C. parvum)
infected immunocompromised mice. Thirty white albino mice were classified into six groups as follow: four study groups, all immunosuppressed and infected with
C. parvum
oocysts. These four groups received treatments as follow:
Group (I):
treated with nitazoxanide.
Group (II):
treated with wheat germ oil.
Group (III):
treated with wheat germ extracted by hexane.
Group (IV):
treated with wheat germ extracted by ethanol. The remaining two groups were immunosuppressed control groups as follow:
Group (V):
only infected with
C. parvum
oocysts (Positive control).
Group (VI):
non-infected (Negative control). Stool samples were collected and examined to detect oocyst and the ileocecal region was subjected to histopathological and immunohistochemical examination. Wheat germ extracts showed a statistically significant effect against
C. parvum
specially wheat germ oil with
P
value: < 0.001, this effect was also confirmed by pathological and immunohistochemical examinations.
C. parvum
has an influence on human health by its effect in diarrheal disease. Wheat germ oil and its extracts has proved to be a reliable herb for
C. parvum.
treatment confirmed by different methodologies.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>36091283</pmid><doi>10.1007/s12639-022-01502-5</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-0394-494X</orcidid></addata></record> |
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| subjects | Antiparasitic agents Developing countries Diarrhea Ethanol Health Promotion and Disease Prevention Infectious Diseases LDCs Medicine Medicine & Public Health Oocysts Original Original Article Protozoa Statistical analysis Wheat germ |
| title | In vivo evaluation of anticryptosporidial effects of wheat germ extracts in immunocompromised mice |
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