mPR-Specific Actions Influence Maintenance of the Blood–Brain Barrier (BBB)

Cerebral cavernous malformations (CCMs) are characterized by abnormally dilated intracranial microvascular sinusoids that result in increased susceptibility to hemorrhagic stroke. It has been demonstrated that three CCM proteins (CCM1, CCM2, and CCM3) form the CCM signaling complex (CSC) to mediate...

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Veröffentlicht in:	International journal of molecular sciences 2022-09, Vol.23 (17), p.9684
Hauptverfasser:	Abou-Fadel, Johnathan, Jiang, Xiaoting, Padarti, Akhil, Goswami, Dinesh G., Smith, Mark, Grajeda, Brian, Bhalli, Muaz, Le, Alexander, Walker, Wendy E., Zhang, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animal models Binding sites Blood-brain barrier Brain Brain damage Brain injury Breast cancer Cancer therapies CCM2 protein Collagen Depletion Disruption Endothelial cells Etiology Feedback Genes Hemorrhage Homeostasis Membrane permeability Microvasculature Mifepristone Mutation Permeability Pregnancy Progesterone Protein expression Proteins Regulation Signs and symptoms Steroids Stroke
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