Mutant p53 Depletion by Novel Inhibitors for HSP40/J-Domain Proteins Derived from the Natural Compound Plumbagin

Accumulation of missense mutant p53 (mutp53) in cancers promotes malignant progression. DNAJA1, a member of HSP40 (also known as J-domain proteins: JDPs), is shown to prevent misfolded or conformational mutp53 from proteasomal degradation. Given frequent addiction of cancers to oncogenic mutp53, dep...

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Veröffentlicht in:	Cancers 2022-08, Vol.14 (17), p.4187
Hauptverfasser:	Alalem, Mohamed, Bhosale, Mrinalini, Ranjan, Atul, Yamamoto, Satomi, Kaida, Atsushi, Nishikawa, Shigeto, Parrales, Alejandro, Farooki, Sana, Anant, Shrikant, Padhye, Subhash, Iwakuma, Tomoo
Format:	Artikel
Sprache:	eng
Schlagworte:	Addictions Alanine Biotechnology Bone cancer Cancer Care and treatment Cell cycle Cell migration CRISPR Genes Health aspects Heat shock proteins Hsp40 protein Isoniazid Laboratories Missense mutant Mutation Natural products p53 Protein Plumbagin Proteasomes Proteins Tongue Transcription factors Tumor proteins Tumor suppressor genes Tumors Tyrosine
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