Interrogating Glioma-Associated Microglia and Macrophage Dynamics Under CSF-1R Therapy with Multitracer In Vivo PET/MRI

Glioma-associated microglia and macrophages (GAMMs) are key players in creating an immunosuppressive microenvironment. They can be efficiently targeted by inhibiting the colony-stimulating factor 1 receptor (CSF-1R). We applied noninvasive PET/CT and PET/MRI using F-fluoroethyltyrosine ( F-FET) (ami...

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Veröffentlicht in:	Journal of Nuclear Medicine 2022-09, Vol.63 (9), p.1386-1393
Hauptverfasser:	Foray, Claudia, Barca, Cristina, Winkeler, Alexandra, Wagner, Stefan, Hermann, Sven, Schäfers, Michael, Grauer, Oliver M, Zinnhardt, Bastian, Jacobs, Andreas H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - metabolism Amines - metabolism Amino acids Amino Acids - metabolism Animals Basic Science Investigation Brain Neoplasms - metabolism Brain tumors Colony-stimulating factor Depletion Fluorine isotopes Fluorine Radioisotopes - metabolism Glioma Glioma - diagnostic imaging Glioma - drug therapy Glioma - metabolism Glioma cells In vivo methods and tests Macrophage colony-stimulating factor Macrophage Colony-Stimulating Factor - metabolism Macrophages Macrophages - metabolism Magnetic Resonance Imaging Metabolism Metastases Mice Mice, Inbred C57BL Microenvironments Microglia Microglia - pathology Positron emission Positron Emission Tomography Computed Tomography Positron-Emission Tomography Preconditioning Pyrimidines - metabolism Pyrimidines - pharmacology Receptor Protein-Tyrosine Kinases - metabolism Repopulation Therapy Tomography Tumors
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