Emerging ROS-Modulating Technologies for Augmentation of the Wound Healing Process

Emerging ROS-Modulating Technologies for Augmentation of the Wound Healing Process

Reactive oxygen species (ROS) is considered a double-edged sword. The slightly elevated level of ROS helps in wound healing by inhibiting microbial infection. In contrast, excessive ROS levels in the wound site show deleterious effects on wound healing by extending the inflammation phase. Understand...

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Veröffentlicht in:ACS omega 2022-09, Vol.7 (35), p.30657-30672
Hauptverfasser: Polaka, Suryanarayana, Katare, Pratik, Pawar, Bhakti, Vasdev, Nupur, Gupta, Tanisha, Rajpoot, Kuldeep, Sengupta, Pinaki, Tekade, Rakesh Kumar
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container_end_page 30672
container_issue 35
container_start_page 30657
container_title ACS omega
container_volume 7
creator Polaka, Suryanarayana
Katare, Pratik
Pawar, Bhakti
Vasdev, Nupur
Gupta, Tanisha
Rajpoot, Kuldeep
Sengupta, Pinaki
Tekade, Rakesh Kumar
description Reactive oxygen species (ROS) is considered a double-edged sword. The slightly elevated level of ROS helps in wound healing by inhibiting microbial infection. In contrast, excessive ROS levels in the wound site show deleterious effects on wound healing by extending the inflammation phase. Understanding the ROS-mediated molecular and biomolecular mechanisms and their effect on cellular homeostasis and inflammation thus substantially improves the possibility of exogenously augmenting and manipulating wound healing with the emerging antioxidant therapeutics. This review comprehensively delves into the relationship between ROS and critical phases of wound healing and the processes underpinning antioxidant therapies. The manuscript also discusses cutting-edge antioxidant therapeutics that act via ROS scavenging to enhance chronic wound healing.
doi_str_mv 10.1021/acsomega.2c02675
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title Emerging ROS-Modulating Technologies for Augmentation of the Wound Healing Process
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