Interleukin-22 Ameliorates Dextran Sulfate Sodium-Induced Colitis through the Upregulation of lncRNA-UCL to Accelerate Claudin-1 Expression via Sequestering miR-568 in Mice

Background. Bioactive compound such as interleukin-22 (IL-22) treatment is regarded as a sufficient treatment for ulcerative colitis (UC). It has been found that long noncoding RNAs (lncRNAs) expressed in many inflammatory diseases, including UC. We aimed to verify the treatment effect of bioactive...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2022, Vol.2022, p.8543720-18
Hauptverfasser:	He, Chonghua, Chen, Zehan, Huang, Jialan, Gan, Riyun, Wang, Jianyao, Wang, Lisheng, Li, Defeng, Yao, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Claudin-1 - biosynthesis Colitis - chemically induced Colitis - drug therapy Colitis - genetics Colitis - metabolism Colitis, Ulcerative - chemically induced Colitis, Ulcerative - drug therapy Colitis, Ulcerative - genetics Cytokines Dextran Sulfate - toxicity Disease Gene expression Inflammatory bowel disease Interleukin-22 Interleukins - pharmacology Laboratory animals Metastasis Mice MicroRNAs - genetics MicroRNAs - metabolism Pathogenesis Proteins RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Tight Junction Proteins - metabolism Up-Regulation
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