Endarterectomy, Stenting, or Medical Treatment for Symptomatic Carotid Near-Occlusion: Results from CAOS, a Multicenter Registry Study

The treatment of symptomatic carotid near-occlusion is controversial. Our aim was to analyze the results of carotid endarterectomy and carotid artery stent placement in patients with symptomatic carotid near-occlusion and to identify factors related to technical failure, periprocedural complications...

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Veröffentlicht in:American journal of neuroradiology : AJNR 2022-09, Vol.43 (9), p.1304-1310
Hauptverfasser: Garcia-Pastor, A, Gil-Núñez, A, Ramirez-Moreno, J M, González-Nafría, N, Tejada, J, Moniche, F, Portilla-Cuenca, J C, Martínez-Sánchez, P, Fuentes, B, Gamero-García, M A, de Leciñana, M A, Masjuan, J, Verge, D C, Aladro, Y, Parkhutik, V, Lago, A, de Arce-Borda, A M, Usero-Ruiz, M, Delgado-Mederos, R, Pampliega, A, Ximenez-Carrillo, Á, Bártulos-Iglesias, M, Castro-Reyes, E
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container_issue 9
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container_title American journal of neuroradiology : AJNR
container_volume 43
creator Garcia-Pastor, A
Gil-Núñez, A
Ramirez-Moreno, J M
González-Nafría, N
Tejada, J
Moniche, F
Portilla-Cuenca, J C
Martínez-Sánchez, P
Fuentes, B
Gamero-García, M A
de Leciñana, M A
Masjuan, J
Verge, D C
Aladro, Y
Parkhutik, V
Lago, A
de Arce-Borda, A M
Usero-Ruiz, M
Delgado-Mederos, R
Pampliega, A
Ximenez-Carrillo, Á
Bártulos-Iglesias, M
Castro-Reyes, E
description The treatment of symptomatic carotid near-occlusion is controversial. Our aim was to analyze the results of carotid endarterectomy and carotid artery stent placement in patients with symptomatic carotid near-occlusion and to identify factors related to technical failure, periprocedural complications, and restenosis. We conducted a multicenter, prospective nonrandomized study. Patients with angiography-confirmed carotid near-occlusion were included. We assessed the revascularization rate and periprocedural stroke or death. Twenty-four-month clinical and carotid imaging follow-up was performed, and rates of carotid restenosis or occlusion, ipsilateral stroke, and mortality were analyzed. Carotid artery stent placement, carotid endarterectomy, and medical treatment were compared. One hundred forty-one patients were included. Forty-four carotid artery stent placement and 23 carotid endarterectomy procedures were performed within 6 months after the event. Complete revascularization was achieved in 83.6%, 81.8% in the carotid artery stent placement group and 87% with carotid endarterectomy ( = .360). Periprocedural stroke or death occurred in 6% (carotid artery stent placement = 2.3%; carotid endarterectomy = 13%; = .077) and was not related to revascularization failure. The carotid restenosis or occlusion rate was 8.3% (5% restenosis, 3.3% occlusion); with carotid artery stent placement it was 10.5%; and with carotid endarterectomy it was 4.5% ( = .419). The 24-month cumulative rate of ipsilateral stroke was 4.8% in the carotid artery stent placement group, 17.4% for carotid endarterectomy, and 13.1% for medical treatment ( = .223). Mortality was 12%, 4.5%, and 5.6%, respectively ( = .422). Revascularization failure and restenosis occurred more frequently in patients with full collapse compared with patients without full collapse (33.3% versus 5.6%, = .009; 21.4% versus 2.9%, = .032, respectively). Carotid artery stent placement and carotid endarterectomy are associated with high rates of failure and periprocedural stroke. Carotid near-occlusion with full collapse appears to be associated with an increased risk of technical failure and restenosis. Carotid near-occlusion revascularization does not seem to reduce the risk of stroke at follow-up compared with medical treatment.
doi_str_mv 10.3174/ajnr.A7617
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Our aim was to analyze the results of carotid endarterectomy and carotid artery stent placement in patients with symptomatic carotid near-occlusion and to identify factors related to technical failure, periprocedural complications, and restenosis. We conducted a multicenter, prospective nonrandomized study. Patients with angiography-confirmed carotid near-occlusion were included. We assessed the revascularization rate and periprocedural stroke or death. Twenty-four-month clinical and carotid imaging follow-up was performed, and rates of carotid restenosis or occlusion, ipsilateral stroke, and mortality were analyzed. Carotid artery stent placement, carotid endarterectomy, and medical treatment were compared. One hundred forty-one patients were included. Forty-four carotid artery stent placement and 23 carotid endarterectomy procedures were performed within 6 months after the event. Complete revascularization was achieved in 83.6%, 81.8% in the carotid artery stent placement group and 87% with carotid endarterectomy ( = .360). Periprocedural stroke or death occurred in 6% (carotid artery stent placement = 2.3%; carotid endarterectomy = 13%; = .077) and was not related to revascularization failure. The carotid restenosis or occlusion rate was 8.3% (5% restenosis, 3.3% occlusion); with carotid artery stent placement it was 10.5%; and with carotid endarterectomy it was 4.5% ( = .419). The 24-month cumulative rate of ipsilateral stroke was 4.8% in the carotid artery stent placement group, 17.4% for carotid endarterectomy, and 13.1% for medical treatment ( = .223). Mortality was 12%, 4.5%, and 5.6%, respectively ( = .422). Revascularization failure and restenosis occurred more frequently in patients with full collapse compared with patients without full collapse (33.3% versus 5.6%, = .009; 21.4% versus 2.9%, = .032, respectively). Carotid artery stent placement and carotid endarterectomy are associated with high rates of failure and periprocedural stroke. Carotid near-occlusion with full collapse appears to be associated with an increased risk of technical failure and restenosis. 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Our aim was to analyze the results of carotid endarterectomy and carotid artery stent placement in patients with symptomatic carotid near-occlusion and to identify factors related to technical failure, periprocedural complications, and restenosis. We conducted a multicenter, prospective nonrandomized study. Patients with angiography-confirmed carotid near-occlusion were included. We assessed the revascularization rate and periprocedural stroke or death. Twenty-four-month clinical and carotid imaging follow-up was performed, and rates of carotid restenosis or occlusion, ipsilateral stroke, and mortality were analyzed. Carotid artery stent placement, carotid endarterectomy, and medical treatment were compared. One hundred forty-one patients were included. Forty-four carotid artery stent placement and 23 carotid endarterectomy procedures were performed within 6 months after the event. Complete revascularization was achieved in 83.6%, 81.8% in the carotid artery stent placement group and 87% with carotid endarterectomy ( = .360). Periprocedural stroke or death occurred in 6% (carotid artery stent placement = 2.3%; carotid endarterectomy = 13%; = .077) and was not related to revascularization failure. The carotid restenosis or occlusion rate was 8.3% (5% restenosis, 3.3% occlusion); with carotid artery stent placement it was 10.5%; and with carotid endarterectomy it was 4.5% ( = .419). The 24-month cumulative rate of ipsilateral stroke was 4.8% in the carotid artery stent placement group, 17.4% for carotid endarterectomy, and 13.1% for medical treatment ( = .223). Mortality was 12%, 4.5%, and 5.6%, respectively ( = .422). Revascularization failure and restenosis occurred more frequently in patients with full collapse compared with patients without full collapse (33.3% versus 5.6%, = .009; 21.4% versus 2.9%, = .032, respectively). Carotid artery stent placement and carotid endarterectomy are associated with high rates of failure and periprocedural stroke. Carotid near-occlusion with full collapse appears to be associated with an increased risk of technical failure and restenosis. 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Gil-Núñez, A ; Ramirez-Moreno, J M ; González-Nafría, N ; Tejada, J ; Moniche, F ; Portilla-Cuenca, J C ; Martínez-Sánchez, P ; Fuentes, B ; Gamero-García, M A ; de Leciñana, M A ; Masjuan, J ; Verge, D C ; Aladro, Y ; Parkhutik, V ; Lago, A ; de Arce-Borda, A M ; Usero-Ruiz, M ; Delgado-Mederos, R ; Pampliega, A ; Ximenez-Carrillo, Á ; Bártulos-Iglesias, M ; Castro-Reyes, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-aafaabf1ef74f589d036cc905a65aba8e0511a29b9d44776bd8c1f2710ccb3353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Carotid Artery Diseases - complications</topic><topic>Carotid Stenosis - complications</topic><topic>Carotid Stenosis - diagnostic imaging</topic><topic>Carotid Stenosis - surgery</topic><topic>Editor's Choice</topic><topic>Endarterectomy, Carotid - adverse effects</topic><topic>Extracranial Vascular</topic><topic>Humans</topic><topic>Prospective Studies</topic><topic>Registries</topic><topic>Risk Factors</topic><topic>Stents - adverse effects</topic><topic>Stroke - complications</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garcia-Pastor, A</creatorcontrib><creatorcontrib>Gil-Núñez, A</creatorcontrib><creatorcontrib>Ramirez-Moreno, J M</creatorcontrib><creatorcontrib>González-Nafría, N</creatorcontrib><creatorcontrib>Tejada, J</creatorcontrib><creatorcontrib>Moniche, F</creatorcontrib><creatorcontrib>Portilla-Cuenca, J C</creatorcontrib><creatorcontrib>Martínez-Sánchez, P</creatorcontrib><creatorcontrib>Fuentes, B</creatorcontrib><creatorcontrib>Gamero-García, M A</creatorcontrib><creatorcontrib>de Leciñana, M A</creatorcontrib><creatorcontrib>Masjuan, J</creatorcontrib><creatorcontrib>Verge, D C</creatorcontrib><creatorcontrib>Aladro, Y</creatorcontrib><creatorcontrib>Parkhutik, V</creatorcontrib><creatorcontrib>Lago, A</creatorcontrib><creatorcontrib>de Arce-Borda, A M</creatorcontrib><creatorcontrib>Usero-Ruiz, M</creatorcontrib><creatorcontrib>Delgado-Mederos, R</creatorcontrib><creatorcontrib>Pampliega, A</creatorcontrib><creatorcontrib>Ximenez-Carrillo, Á</creatorcontrib><creatorcontrib>Bártulos-Iglesias, M</creatorcontrib><creatorcontrib>Castro-Reyes, E</creatorcontrib><creatorcontrib>Stroke Project of the Spanish Cerebrovascular Diseases Study Group</creatorcontrib><creatorcontrib>on behalf of the Stroke Project of the Spanish Cerebrovascular Diseases Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of neuroradiology : AJNR</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garcia-Pastor, A</au><au>Gil-Núñez, A</au><au>Ramirez-Moreno, J M</au><au>González-Nafría, N</au><au>Tejada, J</au><au>Moniche, F</au><au>Portilla-Cuenca, J C</au><au>Martínez-Sánchez, P</au><au>Fuentes, B</au><au>Gamero-García, M A</au><au>de Leciñana, M A</au><au>Masjuan, J</au><au>Verge, D C</au><au>Aladro, Y</au><au>Parkhutik, V</au><au>Lago, A</au><au>de Arce-Borda, A M</au><au>Usero-Ruiz, M</au><au>Delgado-Mederos, R</au><au>Pampliega, A</au><au>Ximenez-Carrillo, Á</au><au>Bártulos-Iglesias, M</au><au>Castro-Reyes, E</au><aucorp>Stroke Project of the Spanish Cerebrovascular Diseases Study Group</aucorp><aucorp>on behalf of the Stroke Project of the Spanish Cerebrovascular Diseases Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endarterectomy, Stenting, or Medical Treatment for Symptomatic Carotid Near-Occlusion: Results from CAOS, a Multicenter Registry Study</atitle><jtitle>American journal of neuroradiology : AJNR</jtitle><addtitle>AJNR Am J Neuroradiol</addtitle><date>2022-09</date><risdate>2022</risdate><volume>43</volume><issue>9</issue><spage>1304</spage><epage>1310</epage><pages>1304-1310</pages><issn>0195-6108</issn><eissn>1936-959X</eissn><abstract>The treatment of symptomatic carotid near-occlusion is controversial. Our aim was to analyze the results of carotid endarterectomy and carotid artery stent placement in patients with symptomatic carotid near-occlusion and to identify factors related to technical failure, periprocedural complications, and restenosis. We conducted a multicenter, prospective nonrandomized study. Patients with angiography-confirmed carotid near-occlusion were included. We assessed the revascularization rate and periprocedural stroke or death. Twenty-four-month clinical and carotid imaging follow-up was performed, and rates of carotid restenosis or occlusion, ipsilateral stroke, and mortality were analyzed. Carotid artery stent placement, carotid endarterectomy, and medical treatment were compared. One hundred forty-one patients were included. Forty-four carotid artery stent placement and 23 carotid endarterectomy procedures were performed within 6 months after the event. Complete revascularization was achieved in 83.6%, 81.8% in the carotid artery stent placement group and 87% with carotid endarterectomy ( = .360). Periprocedural stroke or death occurred in 6% (carotid artery stent placement = 2.3%; carotid endarterectomy = 13%; = .077) and was not related to revascularization failure. The carotid restenosis or occlusion rate was 8.3% (5% restenosis, 3.3% occlusion); with carotid artery stent placement it was 10.5%; and with carotid endarterectomy it was 4.5% ( = .419). The 24-month cumulative rate of ipsilateral stroke was 4.8% in the carotid artery stent placement group, 17.4% for carotid endarterectomy, and 13.1% for medical treatment ( = .223). Mortality was 12%, 4.5%, and 5.6%, respectively ( = .422). Revascularization failure and restenosis occurred more frequently in patients with full collapse compared with patients without full collapse (33.3% versus 5.6%, = .009; 21.4% versus 2.9%, = .032, respectively). Carotid artery stent placement and carotid endarterectomy are associated with high rates of failure and periprocedural stroke. Carotid near-occlusion with full collapse appears to be associated with an increased risk of technical failure and restenosis. Carotid near-occlusion revascularization does not seem to reduce the risk of stroke at follow-up compared with medical treatment.</abstract><cop>United States</cop><pub>American Society of Neuroradiology</pub><pmid>35981762</pmid><doi>10.3174/ajnr.A7617</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-0363-862X</orcidid><orcidid>https://orcid.org/0000-0001-8885-2192</orcidid><orcidid>https://orcid.org/0000-0001-8613-2909</orcidid><orcidid>https://orcid.org/0000-0003-1329-0943</orcidid><orcidid>https://orcid.org/0000-0001-5009-2722</orcidid><orcidid>https://orcid.org/0000-0002-0090-8807</orcidid><orcidid>https://orcid.org/0000-0001-5061-1510</orcidid><orcidid>https://orcid.org/0000-0002-5677-2144</orcidid><orcidid>https://orcid.org/0000-0003-4135-1280</orcidid><orcidid>https://orcid.org/0000-0002-4195-7752</orcidid><orcidid>https://orcid.org/0000-0002-2783-2013</orcidid><orcidid>https://orcid.org/0000-0003-1945-4435</orcidid><orcidid>https://orcid.org/0000-0002-5167-1571</orcidid><orcidid>https://orcid.org/0000-0001-5258-3277</orcidid><orcidid>https://orcid.org/0000-0002-8983-4583</orcidid><orcidid>https://orcid.org/0000-0002-0796-0990</orcidid><orcidid>https://orcid.org/0000-0002-3483-8106</orcidid><orcidid>https://orcid.org/0000-0002-1141-5311</orcidid><orcidid>https://orcid.org/0000-0002-0405-5282</orcidid><orcidid>https://orcid.org/0000-0002-4302-6580</orcidid><orcidid>https://orcid.org/0000-0001-9459-5452</orcidid><orcidid>https://orcid.org/0000-0003-3737-7226</orcidid><orcidid>https://orcid.org/0000-0003-0043-6501</orcidid><oa>free_for_read</oa></addata></record>
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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central
subjects Carotid Artery Diseases - complications
Carotid Stenosis - complications
Carotid Stenosis - diagnostic imaging
Carotid Stenosis - surgery
Editor's Choice
Endarterectomy, Carotid - adverse effects
Extracranial Vascular
Humans
Prospective Studies
Registries
Risk Factors
Stents - adverse effects
Stroke - complications
Treatment Outcome
title Endarterectomy, Stenting, or Medical Treatment for Symptomatic Carotid Near-Occlusion: Results from CAOS, a Multicenter Registry Study
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