Optimized Pyridazinone Nutrient Channel Inhibitors Are Potent and Specific Antimalarial Leads

Human and animal malaria parasites increase their host erythrocyte permeability to a broad range of solutes as mediated by parasite-associated ion channels. Molecular and pharmacological studies have implicated an essential role in parasite nutrient acquisition, but inhibitors suitable for developme...

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Veröffentlicht in:	Molecular pharmacology 2022-09, Vol.102 (3), p.172-182
Hauptverfasser:	Butler, Michelle M., Waidyarachchi, Samanthi L., Shao, Jinfeng, Nguyen, Son T., Ding, Xiaoyuan, Cardinale, Steven C., Morin, Lucas R., Kwasny, Steven M., Ito, Mai, Gezelle, Jeanine, Jiménez-Díaz, María B., Angulo-Barturen, Iñigo, Jacobs, Robert T., Burrows, Jeremy N., Aron, Zachary D., Bowlin, Terry L., Desai, Sanjay A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anions - chemistry Anions - metabolism Antimalarials - pharmacology Erythrocytes - metabolism Folic Acid Antagonists Humans Nutrients Plasmodium falciparum - metabolism
Online-Zugang:	Volltext
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