Hyperproliferation markers in ear canal epidermis
Several studies involving immunohistochemical methods to assess external auditory canal epidermis have been performed with different objectives. With this method it is possible to assess the expression of various antigens such as cytokeratins, cytokines, and hyperproliferation markers among others....
Gespeichert in:
| Veröffentlicht in: | Brazilian journal of otorhinolaryngology 2010-09, Vol.76 (5), p.667-671 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 671 |
|---|---|
| container_issue | 5 |
| container_start_page | 667 |
| container_title | Brazilian journal of otorhinolaryngology |
| container_volume | 76 |
| creator | Gurgel, João Daniel Caliman e Pereira, Celina Siqueira Barbosa Alves, Adriana Leal Ribeiro, Fernando Quintanilha |
| description | Several studies involving immunohistochemical methods to assess external auditory canal epidermis have been performed with different objectives. With this method it is possible to assess the expression of various antigens such as cytokeratins, cytokines, and hyperproliferation markers among others.
to revise, describe and analyze the knowledge generated by identifiable papers published on the worldwide literature about immunohistochemical hyperproliferation markers in normal external auditory canal epidermis.
systematic review of the papers published until 2009, in indexed international journals.
Various antigens related to hyperproliferation were investigated by immunohistochemical methods among the included papers. The most studied ones were cytokeratin 16, Ki-67 and PCNA.
most of the studies utilized external auditory canal epidermis as control sample to study external ear or middle ear cholesteatoma with immunohistochemical methods. There is a hyperproliferative antigen concentration, such as CK16, Ki-67 and PCNA, in the annulus tympanicus, adjacent meatus and tympanic regions, mainly in the lower areas. |
| doi_str_mv | 10.1590/S1808-86942010000500023 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9450777</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1808869415309289</els_id><sourcerecordid>760238820</sourcerecordid><originalsourceid>FETCH-LOGICAL-e323t-bda02b9d786af91884626774d513154d5afc8de45f8aa4d2ed0f8795797e20c93</originalsourceid><addsrcrecordid>eNplUU1LAzEQDaJYrf4F3Zunaj42XxehFLVCwYN6Dmkyq9Ht7ppsC_33RluL4sAwA_N4b2YeQucEXxKu8dUjUViNlNAlxQTn4Dkp20NH24ES-7telwN0nNIbxkJiyQ_RgGItGOP8CJHpuoPYxbYOFUTbh7YpFja-Q0xFaAqwsXC2sXUBXfAQFyGdoIPK1glOt3WInm9vnibT0ezh7n4yno2AUdaP5t5iOtdeKmErTZQqBRVSlp4TRngutnLKQ8krZW3pKXhcKam51BIodpoN0fWGt1vOF-AdNH20teliyPutTWuD-Ttpwqt5aVdGlxxLKTPBxZYgth9LSL3J2zuoa9tAu0xGivwxpSjOyLPfUjuNnzdlwHgDgHzwKkA0yQVoHPgQwfXGt8EQbL6sMd_WmH_WsE8WZn_8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>760238820</pqid></control><display><type>article</type><title>Hyperproliferation markers in ear canal epidermis</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Gurgel, João Daniel Caliman e ; Pereira, Celina Siqueira Barbosa ; Alves, Adriana Leal ; Ribeiro, Fernando Quintanilha</creator><creatorcontrib>Gurgel, João Daniel Caliman e ; Pereira, Celina Siqueira Barbosa ; Alves, Adriana Leal ; Ribeiro, Fernando Quintanilha</creatorcontrib><description>Several studies involving immunohistochemical methods to assess external auditory canal epidermis have been performed with different objectives. With this method it is possible to assess the expression of various antigens such as cytokeratins, cytokines, and hyperproliferation markers among others.
to revise, describe and analyze the knowledge generated by identifiable papers published on the worldwide literature about immunohistochemical hyperproliferation markers in normal external auditory canal epidermis.
systematic review of the papers published until 2009, in indexed international journals.
Various antigens related to hyperproliferation were investigated by immunohistochemical methods among the included papers. The most studied ones were cytokeratin 16, Ki-67 and PCNA.
most of the studies utilized external auditory canal epidermis as control sample to study external ear or middle ear cholesteatoma with immunohistochemical methods. There is a hyperproliferative antigen concentration, such as CK16, Ki-67 and PCNA, in the annulus tympanicus, adjacent meatus and tympanic regions, mainly in the lower areas.</description><identifier>ISSN: 1808-8694</identifier><identifier>EISSN: 1808-8686</identifier><identifier>DOI: 10.1590/S1808-86942010000500023</identifier><identifier>PMID: 20963355</identifier><language>eng</language><publisher>Brazil: Elsevier Editora Ltda</publisher><subject>Biomarkers - analysis ; Cell Proliferation ; cholesteatoma ; Cholesteatoma, Middle Ear - metabolism ; ear canal ; Ear Canal - metabolism ; Epidermis - metabolism ; Humans ; Immunohistochemistry ; Keratin-16 - analysis ; keratins ; Ki-67 Antigen - analysis ; Proliferating Cell Nuclear Antigen - analysis ; Review ; Tympanic Membrane</subject><ispartof>Brazilian journal of otorhinolaryngology, 2010-09, Vol.76 (5), p.667-671</ispartof><rights>2010 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450777/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450777/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20963355$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gurgel, João Daniel Caliman e</creatorcontrib><creatorcontrib>Pereira, Celina Siqueira Barbosa</creatorcontrib><creatorcontrib>Alves, Adriana Leal</creatorcontrib><creatorcontrib>Ribeiro, Fernando Quintanilha</creatorcontrib><title>Hyperproliferation markers in ear canal epidermis</title><title>Brazilian journal of otorhinolaryngology</title><addtitle>Braz J Otorhinolaryngol</addtitle><description>Several studies involving immunohistochemical methods to assess external auditory canal epidermis have been performed with different objectives. With this method it is possible to assess the expression of various antigens such as cytokeratins, cytokines, and hyperproliferation markers among others.
to revise, describe and analyze the knowledge generated by identifiable papers published on the worldwide literature about immunohistochemical hyperproliferation markers in normal external auditory canal epidermis.
systematic review of the papers published until 2009, in indexed international journals.
Various antigens related to hyperproliferation were investigated by immunohistochemical methods among the included papers. The most studied ones were cytokeratin 16, Ki-67 and PCNA.
most of the studies utilized external auditory canal epidermis as control sample to study external ear or middle ear cholesteatoma with immunohistochemical methods. There is a hyperproliferative antigen concentration, such as CK16, Ki-67 and PCNA, in the annulus tympanicus, adjacent meatus and tympanic regions, mainly in the lower areas.</description><subject>Biomarkers - analysis</subject><subject>Cell Proliferation</subject><subject>cholesteatoma</subject><subject>Cholesteatoma, Middle Ear - metabolism</subject><subject>ear canal</subject><subject>Ear Canal - metabolism</subject><subject>Epidermis - metabolism</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Keratin-16 - analysis</subject><subject>keratins</subject><subject>Ki-67 Antigen - analysis</subject><subject>Proliferating Cell Nuclear Antigen - analysis</subject><subject>Review</subject><subject>Tympanic Membrane</subject><issn>1808-8694</issn><issn>1808-8686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplUU1LAzEQDaJYrf4F3Zunaj42XxehFLVCwYN6Dmkyq9Ht7ppsC_33RluL4sAwA_N4b2YeQucEXxKu8dUjUViNlNAlxQTn4Dkp20NH24ES-7telwN0nNIbxkJiyQ_RgGItGOP8CJHpuoPYxbYOFUTbh7YpFja-Q0xFaAqwsXC2sXUBXfAQFyGdoIPK1glOt3WInm9vnibT0ezh7n4yno2AUdaP5t5iOtdeKmErTZQqBRVSlp4TRngutnLKQ8krZW3pKXhcKam51BIodpoN0fWGt1vOF-AdNH20teliyPutTWuD-Ttpwqt5aVdGlxxLKTPBxZYgth9LSL3J2zuoa9tAu0xGivwxpSjOyLPfUjuNnzdlwHgDgHzwKkA0yQVoHPgQwfXGt8EQbL6sMd_WmH_WsE8WZn_8</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Gurgel, João Daniel Caliman e</creator><creator>Pereira, Celina Siqueira Barbosa</creator><creator>Alves, Adriana Leal</creator><creator>Ribeiro, Fernando Quintanilha</creator><general>Elsevier Editora Ltda</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100901</creationdate><title>Hyperproliferation markers in ear canal epidermis</title><author>Gurgel, João Daniel Caliman e ; Pereira, Celina Siqueira Barbosa ; Alves, Adriana Leal ; Ribeiro, Fernando Quintanilha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e323t-bda02b9d786af91884626774d513154d5afc8de45f8aa4d2ed0f8795797e20c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Biomarkers - analysis</topic><topic>Cell Proliferation</topic><topic>cholesteatoma</topic><topic>Cholesteatoma, Middle Ear - metabolism</topic><topic>ear canal</topic><topic>Ear Canal - metabolism</topic><topic>Epidermis - metabolism</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Keratin-16 - analysis</topic><topic>keratins</topic><topic>Ki-67 Antigen - analysis</topic><topic>Proliferating Cell Nuclear Antigen - analysis</topic><topic>Review</topic><topic>Tympanic Membrane</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gurgel, João Daniel Caliman e</creatorcontrib><creatorcontrib>Pereira, Celina Siqueira Barbosa</creatorcontrib><creatorcontrib>Alves, Adriana Leal</creatorcontrib><creatorcontrib>Ribeiro, Fernando Quintanilha</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Brazilian journal of otorhinolaryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gurgel, João Daniel Caliman e</au><au>Pereira, Celina Siqueira Barbosa</au><au>Alves, Adriana Leal</au><au>Ribeiro, Fernando Quintanilha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperproliferation markers in ear canal epidermis</atitle><jtitle>Brazilian journal of otorhinolaryngology</jtitle><addtitle>Braz J Otorhinolaryngol</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>76</volume><issue>5</issue><spage>667</spage><epage>671</epage><pages>667-671</pages><issn>1808-8694</issn><eissn>1808-8686</eissn><abstract>Several studies involving immunohistochemical methods to assess external auditory canal epidermis have been performed with different objectives. With this method it is possible to assess the expression of various antigens such as cytokeratins, cytokines, and hyperproliferation markers among others.
to revise, describe and analyze the knowledge generated by identifiable papers published on the worldwide literature about immunohistochemical hyperproliferation markers in normal external auditory canal epidermis.
systematic review of the papers published until 2009, in indexed international journals.
Various antigens related to hyperproliferation were investigated by immunohistochemical methods among the included papers. The most studied ones were cytokeratin 16, Ki-67 and PCNA.
most of the studies utilized external auditory canal epidermis as control sample to study external ear or middle ear cholesteatoma with immunohistochemical methods. There is a hyperproliferative antigen concentration, such as CK16, Ki-67 and PCNA, in the annulus tympanicus, adjacent meatus and tympanic regions, mainly in the lower areas.</abstract><cop>Brazil</cop><pub>Elsevier Editora Ltda</pub><pmid>20963355</pmid><doi>10.1590/S1808-86942010000500023</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1808-8694 |
| ispartof | Brazilian journal of otorhinolaryngology, 2010-09, Vol.76 (5), p.667-671 |
| issn | 1808-8694 1808-8686 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9450777 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Biomarkers - analysis Cell Proliferation cholesteatoma Cholesteatoma, Middle Ear - metabolism ear canal Ear Canal - metabolism Epidermis - metabolism Humans Immunohistochemistry Keratin-16 - analysis keratins Ki-67 Antigen - analysis Proliferating Cell Nuclear Antigen - analysis Review Tympanic Membrane |
| title | Hyperproliferation markers in ear canal epidermis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T21%3A27%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hyperproliferation%20markers%20in%20ear%20canal%20epidermis&rft.jtitle=Brazilian%20journal%20of%20otorhinolaryngology&rft.au=Gurgel,%20Jo%C3%A3o%20Daniel%20Caliman%20e&rft.date=2010-09-01&rft.volume=76&rft.issue=5&rft.spage=667&rft.epage=671&rft.pages=667-671&rft.issn=1808-8694&rft.eissn=1808-8686&rft_id=info:doi/10.1590/S1808-86942010000500023&rft_dat=%3Cproquest_pubme%3E760238820%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=760238820&rft_id=info:pmid/20963355&rft_els_id=S1808869415309289&rfr_iscdi=true |