Parietal Cell Dysfunction: A Rare Cause of Gastric Neuroendocrine Neoplasm with Achlorhydria and Extreme Hypergastrinemia
A 69-year-old woman with multiple neuroendocrine neoplasms (NENs) was referred to our hospital. Although she had extreme hypergastrinemia (11,675 pg/mL), no findings that indicated types I to III gastric NENs were found. Although gastric corpus atrophy was suspected on conventional white-light imagi...
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| Veröffentlicht in: | Internal Medicine 2022/08/15, Vol.61(16), pp.2441-2448 |
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| creator | Abe, Yasuaki Hatta, Waku Asonuma, Sho Koike, Tomoyuki Abe, Hiroko Ogata, Yohei Saito, Masahiro Jin, Xiaoyi Kanno, Takeshi Uno, Kaname Asano, Naoki Imatani, Akira Fujishima, Fumiyoshi Sasano, Hironobu Masamune, Atsushi |
| description | A 69-year-old woman with multiple neuroendocrine neoplasms (NENs) was referred to our hospital. Although she had extreme hypergastrinemia (11,675 pg/mL), no findings that indicated types I to III gastric NENs were found. Although gastric corpus atrophy was suspected on conventional white-light imaging, findings on magnifying endoscopy with narrow-band imaging indicated no severe atrophy. A biopsy from the background fundic gland mucosa revealed no atrophic changes, parietal cells with vacuolated cytoplasm and negative findings for H+K+-ATPase. Thus, this case was diagnosed as multiple NENs with parietal cell dysfunction. Neither progression nor metastasis has been confirmed during two-year follow-up. |
| doi_str_mv | 10.2169/internalmedicine.8253-21 |
| format | Article |
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Although she had extreme hypergastrinemia (11,675 pg/mL), no findings that indicated types I to III gastric NENs were found. Although gastric corpus atrophy was suspected on conventional white-light imaging, findings on magnifying endoscopy with narrow-band imaging indicated no severe atrophy. A biopsy from the background fundic gland mucosa revealed no atrophic changes, parietal cells with vacuolated cytoplasm and negative findings for H+K+-ATPase. Thus, this case was diagnosed as multiple NENs with parietal cell dysfunction. Neither progression nor metastasis has been confirmed during two-year follow-up.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.8253-21</identifier><identifier>PMID: 35110476</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>achlorhydria ; Atrophy ; Biopsy ; Case Report ; Cytoplasm ; Endoscopy ; hypergastrinemia ; Internal medicine ; Metastases ; neuroendocrine neoplasms ; Neuroendocrine tumors ; parietal cell dysfunction ; Parietal cells</subject><ispartof>Internal Medicine, 2022/08/15, Vol.61(16), pp.2441-2448</ispartof><rights>2022 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2022</rights><rights>Copyright © 2022 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c610t-473ca947ce6348d1fb3341478518bb681984f92ff3e927211069d0c26af3f0c93</citedby><cites>FETCH-LOGICAL-c610t-473ca947ce6348d1fb3341478518bb681984f92ff3e927211069d0c26af3f0c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449610/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449610/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1877,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35110476$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abe, Yasuaki</creatorcontrib><creatorcontrib>Hatta, Waku</creatorcontrib><creatorcontrib>Asonuma, Sho</creatorcontrib><creatorcontrib>Koike, Tomoyuki</creatorcontrib><creatorcontrib>Abe, Hiroko</creatorcontrib><creatorcontrib>Ogata, Yohei</creatorcontrib><creatorcontrib>Saito, Masahiro</creatorcontrib><creatorcontrib>Jin, Xiaoyi</creatorcontrib><creatorcontrib>Kanno, Takeshi</creatorcontrib><creatorcontrib>Uno, Kaname</creatorcontrib><creatorcontrib>Asano, Naoki</creatorcontrib><creatorcontrib>Imatani, Akira</creatorcontrib><creatorcontrib>Fujishima, Fumiyoshi</creatorcontrib><creatorcontrib>Sasano, Hironobu</creatorcontrib><creatorcontrib>Masamune, Atsushi</creatorcontrib><title>Parietal Cell Dysfunction: A Rare Cause of Gastric Neuroendocrine Neoplasm with Achlorhydria and Extreme Hypergastrinemia</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>A 69-year-old woman with multiple neuroendocrine neoplasms (NENs) was referred to our hospital. Although she had extreme hypergastrinemia (11,675 pg/mL), no findings that indicated types I to III gastric NENs were found. Although gastric corpus atrophy was suspected on conventional white-light imaging, findings on magnifying endoscopy with narrow-band imaging indicated no severe atrophy. A biopsy from the background fundic gland mucosa revealed no atrophic changes, parietal cells with vacuolated cytoplasm and negative findings for H+K+-ATPase. Thus, this case was diagnosed as multiple NENs with parietal cell dysfunction. Neither progression nor metastasis has been confirmed during two-year follow-up.</description><subject>achlorhydria</subject><subject>Atrophy</subject><subject>Biopsy</subject><subject>Case Report</subject><subject>Cytoplasm</subject><subject>Endoscopy</subject><subject>hypergastrinemia</subject><subject>Internal medicine</subject><subject>Metastases</subject><subject>neuroendocrine neoplasms</subject><subject>Neuroendocrine tumors</subject><subject>parietal cell dysfunction</subject><subject>Parietal cells</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNplkduO0zAQhiMEYrsLr4AsccNNFp_ixFwgVWUPSCsWIbi2XGfSuErsYjsLeXtcWipYbsay5pt_Dn9RIIIvKRHyrXUJgtPDCK011sFlQytWUvKkWBDGZVlTVj0tFliSpqQ5nBXnMW4xZk0t6fPijFWEYF6LRTF_1sFC0gNawTCgD3PsJmeS9e4dWqIvOgBa6SkC8h260TEFa9AnmIIH13oTcu_89btBxxH9sKlHS9MPPvRzG6xG2rXo6mcKMAK6nXcQNr8lHIxWvyiedXqI8PL4XhTfrq--rm7Lu_ubj6vlXWkEwankNTNa8tqAYLxpSbdmjBNeNxVp1mvRENnwTtKuYyBpTfNeQrbYUKE71mEj2UXx_qC7m9b5XgZcCnpQu2BHHWbltVX_Zpzt1cY_KMm5zCNkgTdHgeC_TxCTGm00-VragZ-iooJWVOS2LKOvH6FbP-2NylSNJW54JXmmmgNlgo8xQHcahmC191c99lft_c2pXPrq72VOhX8MzcD9AdjGpDdwAnRI1gzwv7Igioh9PLY4kabXQYFjvwD9o8V9</recordid><startdate>20220815</startdate><enddate>20220815</enddate><creator>Abe, Yasuaki</creator><creator>Hatta, Waku</creator><creator>Asonuma, Sho</creator><creator>Koike, Tomoyuki</creator><creator>Abe, Hiroko</creator><creator>Ogata, Yohei</creator><creator>Saito, Masahiro</creator><creator>Jin, Xiaoyi</creator><creator>Kanno, Takeshi</creator><creator>Uno, Kaname</creator><creator>Asano, Naoki</creator><creator>Imatani, Akira</creator><creator>Fujishima, Fumiyoshi</creator><creator>Sasano, Hironobu</creator><creator>Masamune, Atsushi</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220815</creationdate><title>Parietal Cell Dysfunction: A Rare Cause of Gastric Neuroendocrine Neoplasm with Achlorhydria and Extreme Hypergastrinemia</title><author>Abe, Yasuaki ; Hatta, Waku ; Asonuma, Sho ; Koike, Tomoyuki ; Abe, Hiroko ; Ogata, Yohei ; Saito, Masahiro ; Jin, Xiaoyi ; Kanno, Takeshi ; Uno, Kaname ; Asano, Naoki ; Imatani, Akira ; Fujishima, Fumiyoshi ; Sasano, Hironobu ; Masamune, Atsushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c610t-473ca947ce6348d1fb3341478518bb681984f92ff3e927211069d0c26af3f0c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>achlorhydria</topic><topic>Atrophy</topic><topic>Biopsy</topic><topic>Case Report</topic><topic>Cytoplasm</topic><topic>Endoscopy</topic><topic>hypergastrinemia</topic><topic>Internal medicine</topic><topic>Metastases</topic><topic>neuroendocrine neoplasms</topic><topic>Neuroendocrine tumors</topic><topic>parietal cell dysfunction</topic><topic>Parietal cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abe, Yasuaki</creatorcontrib><creatorcontrib>Hatta, Waku</creatorcontrib><creatorcontrib>Asonuma, Sho</creatorcontrib><creatorcontrib>Koike, Tomoyuki</creatorcontrib><creatorcontrib>Abe, Hiroko</creatorcontrib><creatorcontrib>Ogata, Yohei</creatorcontrib><creatorcontrib>Saito, Masahiro</creatorcontrib><creatorcontrib>Jin, Xiaoyi</creatorcontrib><creatorcontrib>Kanno, Takeshi</creatorcontrib><creatorcontrib>Uno, Kaname</creatorcontrib><creatorcontrib>Asano, Naoki</creatorcontrib><creatorcontrib>Imatani, Akira</creatorcontrib><creatorcontrib>Fujishima, Fumiyoshi</creatorcontrib><creatorcontrib>Sasano, Hironobu</creatorcontrib><creatorcontrib>Masamune, Atsushi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abe, Yasuaki</au><au>Hatta, Waku</au><au>Asonuma, Sho</au><au>Koike, Tomoyuki</au><au>Abe, Hiroko</au><au>Ogata, Yohei</au><au>Saito, Masahiro</au><au>Jin, Xiaoyi</au><au>Kanno, Takeshi</au><au>Uno, Kaname</au><au>Asano, Naoki</au><au>Imatani, Akira</au><au>Fujishima, Fumiyoshi</au><au>Sasano, Hironobu</au><au>Masamune, Atsushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parietal Cell Dysfunction: A Rare Cause of Gastric Neuroendocrine Neoplasm with Achlorhydria and Extreme Hypergastrinemia</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2022-08-15</date><risdate>2022</risdate><volume>61</volume><issue>16</issue><spage>2441</spage><epage>2448</epage><pages>2441-2448</pages><artnum>8253-21</artnum><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>A 69-year-old woman with multiple neuroendocrine neoplasms (NENs) was referred to our hospital. Although she had extreme hypergastrinemia (11,675 pg/mL), no findings that indicated types I to III gastric NENs were found. Although gastric corpus atrophy was suspected on conventional white-light imaging, findings on magnifying endoscopy with narrow-band imaging indicated no severe atrophy. A biopsy from the background fundic gland mucosa revealed no atrophic changes, parietal cells with vacuolated cytoplasm and negative findings for H+K+-ATPase. Thus, this case was diagnosed as multiple NENs with parietal cell dysfunction. 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| subjects | achlorhydria Atrophy Biopsy Case Report Cytoplasm Endoscopy hypergastrinemia Internal medicine Metastases neuroendocrine neoplasms Neuroendocrine tumors parietal cell dysfunction Parietal cells |
| title | Parietal Cell Dysfunction: A Rare Cause of Gastric Neuroendocrine Neoplasm with Achlorhydria and Extreme Hypergastrinemia |
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