Inducing oscillations in positive end-expiratory pressure improves assessment of cerebrovascular pressure reactivity in patients with traumatic brain injury
Cerebral autoregulation assessment requires sufficient slow arterial blood pressure (ABP) waves. However, spontaneous ABP waves may be insufficient for reliable cerebral autoregulation estimations. Therefore, we applied a ventilator “sigh-function” to generate positive end-expiratory pressure oscill...
Gespeichert in:
| Veröffentlicht in: | Journal of applied physiology (1985) 2022-09, Vol.133 (3), p.585-592 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 592 |
|---|---|
| container_issue | 3 |
| container_start_page | 585 |
| container_title | Journal of applied physiology (1985) |
| container_volume | 133 |
| creator | Tas, Jeanette Bos, Kirsten D. J. Le Feber, Joost Beqiri, Erta Czosnyka, Marek Haeren, Roel van der Horst, Iwan C. C. van Kuijk, Sander M. J. Strauch, Ulrich Brady, Ken M. Smielewski, Peter Aries, Marcel J. H. |
| description | Cerebral autoregulation assessment requires sufficient slow arterial blood pressure (ABP) waves. However, spontaneous ABP waves may be insufficient for reliable cerebral autoregulation estimations. Therefore, we applied a ventilator “sigh-function” to generate positive end-expiratory pressure oscillations that induce slow ABP waves. This method demonstrated a reduced variability of the pressure reactivity index, commonly used as continuous cerebral autoregulation measure in a traumatic brain injury population.
The cerebral pressure reactivity index (PRx), through intracranial pressure (ICP) measurements, informs clinicians about the cerebral autoregulation (CA) status in adult-sedated patients with traumatic brain injury (TBI). Using PRx in clinical practice is currently limited by variability over shorter monitoring periods. We applied an innovative method to reduce the PRx variability by ventilator-induced slow (1/min) positive end-expiratory pressure (PEEP) oscillations. We hypothesized that, as seen in a previous animal model, the PRx variability would be reduced by inducing slow arterial blood pressure (ABP) and ICP oscillations without other clinically relevant physiological changes. Patients with TBI were ventilated with a static PEEP for 30 min (PRx period) followed by a 30-min period of slow [1/min (0.0167 Hz)] +5 cmH
2
O PEEP oscillations (induced ( iPRx period). Ten patients with TBI were included. No clinical monitoring was discontinued and no additional interventions were required during the iPRx period. The PRx variability [measured as the standard deviation (SD) of PRx] decreased significantly during the iPRx period from 0.25 (0.22–0.30) to 0.14 (0.09–0.17) ( P = 0.006). There was a power increase around the induced frequency (1/min) for both ABP and ICP ( P = 0.002). In conclusion, 1/min PEEP-induced oscillations reduced the PRx variability in patients with TBI with ICP levels |
| doi_str_mv | 10.1152/japplphysiol.00199.2022 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9448337</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2709763994</sourcerecordid><originalsourceid>FETCH-LOGICAL-c422t-1b505570325cbd4eae31e835bd1ec42ba187b2442d39688197596c61cb9cc3af3</originalsourceid><addsrcrecordid>eNpdkstu1TAQhi1ERU8Lz4AlNmxy8CWO4w0SqoBWqsSGri3HmdPjo8QOnuRA3qUPW_cibquR5v_mn7H1E_KWsy3nSnw4uGkapv2KIQ1bxrgxW8GEeEE2RRUVbxh_STatVqzSqtWn5AzxULi6VvwVOZVKm6bhckPurmK_-BBvaUIfhsHNIUWkIdIpYZjDESjEvoJfU8huTnmlUwbEJQMN45TTEZA6xNIaIc407aiHDF0RHPplcPkPn8H5Yhjm9dG-bCoTSH-GeU_n7JaxdDztsitqiIclr6_Jyc4NCG-e6zm5-fL5-8Vldf3t69XFp-vK10LMFe8UU0ozKZTv-hocSA6tVF3PoRCd463uRF2LXpqmbbnRyjS-4b4z3ku3k-fk45PvtHQj9L7cld1gpxxGl1ebXLD_KjHs7W06WlPXrZS6GLx_NsjpxwI42zGgh_KdEdKCVjRtw8pS3Rb03X_oIS05ludZoZnRjTSmLpR-onxOiBl2v4_hzD4kwP6dAPuYAPuQAHkPdeqtuA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2709763994</pqid></control><display><type>article</type><title>Inducing oscillations in positive end-expiratory pressure improves assessment of cerebrovascular pressure reactivity in patients with traumatic brain injury</title><source>American Physiological Society</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Tas, Jeanette ; Bos, Kirsten D. J. ; Le Feber, Joost ; Beqiri, Erta ; Czosnyka, Marek ; Haeren, Roel ; van der Horst, Iwan C. C. ; van Kuijk, Sander M. J. ; Strauch, Ulrich ; Brady, Ken M. ; Smielewski, Peter ; Aries, Marcel J. H.</creator><creatorcontrib>Tas, Jeanette ; Bos, Kirsten D. J. ; Le Feber, Joost ; Beqiri, Erta ; Czosnyka, Marek ; Haeren, Roel ; van der Horst, Iwan C. C. ; van Kuijk, Sander M. J. ; Strauch, Ulrich ; Brady, Ken M. ; Smielewski, Peter ; Aries, Marcel J. H.</creatorcontrib><description>Cerebral autoregulation assessment requires sufficient slow arterial blood pressure (ABP) waves. However, spontaneous ABP waves may be insufficient for reliable cerebral autoregulation estimations. Therefore, we applied a ventilator “sigh-function” to generate positive end-expiratory pressure oscillations that induce slow ABP waves. This method demonstrated a reduced variability of the pressure reactivity index, commonly used as continuous cerebral autoregulation measure in a traumatic brain injury population.
The cerebral pressure reactivity index (PRx), through intracranial pressure (ICP) measurements, informs clinicians about the cerebral autoregulation (CA) status in adult-sedated patients with traumatic brain injury (TBI). Using PRx in clinical practice is currently limited by variability over shorter monitoring periods. We applied an innovative method to reduce the PRx variability by ventilator-induced slow (1/min) positive end-expiratory pressure (PEEP) oscillations. We hypothesized that, as seen in a previous animal model, the PRx variability would be reduced by inducing slow arterial blood pressure (ABP) and ICP oscillations without other clinically relevant physiological changes. Patients with TBI were ventilated with a static PEEP for 30 min (PRx period) followed by a 30-min period of slow [1/min (0.0167 Hz)] +5 cmH
2
O PEEP oscillations (induced ( iPRx period). Ten patients with TBI were included. No clinical monitoring was discontinued and no additional interventions were required during the iPRx period. The PRx variability [measured as the standard deviation (SD) of PRx] decreased significantly during the iPRx period from 0.25 (0.22–0.30) to 0.14 (0.09–0.17) ( P = 0.006). There was a power increase around the induced frequency (1/min) for both ABP and ICP ( P = 0.002). In conclusion, 1/min PEEP-induced oscillations reduced the PRx variability in patients with TBI with ICP levels <22 mmHg. No other clinically relevant physiological changes were observed. Reduced PRx variability might improve CA-guided perfusion management by reducing the time to find “optimal” perfusion pressure targets. Larger studies with prolonged periods of PEEP-induced oscillations are required to take it to routine use.
NEW & NOTEWORTHY Cerebral autoregulation assessment requires sufficient slow arterial blood pressure (ABP) waves. However, spontaneous ABP waves may be insufficient for reliable cerebral autoregulation estimations. Therefore, we applied a ventilator “sigh-function” to generate positive end-expiratory pressure oscillations that induce slow ABP waves. This method demonstrated a reduced variability of the pressure reactivity index, commonly used as continuous cerebral autoregulation measure in a traumatic brain injury population.</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/japplphysiol.00199.2022</identifier><identifier>PMID: 35796613</identifier><language>eng</language><publisher>Bethesda: American Physiological Society</publisher><subject>Animal models ; Blood pressure ; Brain ; Head injuries ; Injury prevention ; Innovative Methodology ; Intracranial pressure ; Monitoring ; Oscillations ; Patients ; Perfusion ; Physiology ; Telemedicine ; Traumatic brain injury ; Variability</subject><ispartof>Journal of applied physiology (1985), 2022-09, Vol.133 (3), p.585-592</ispartof><rights>Copyright American Physiological Society Sep 2022</rights><rights>Copyright © 2022 the American Physiological Society. 2022 American Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-1b505570325cbd4eae31e835bd1ec42ba187b2442d39688197596c61cb9cc3af3</citedby><cites>FETCH-LOGICAL-c422t-1b505570325cbd4eae31e835bd1ec42ba187b2442d39688197596c61cb9cc3af3</cites><orcidid>0000-0002-8108-0000 ; 0000-0003-2796-729X ; 0000-0001-5327-1275 ; 0000-0002-0605-1437 ; 0000-0001-5096-3938 ; 0000-0002-8914-0960 ; 0000-0003-1640-5013 ; 0000-0003-3891-8522 ; 0000-0003-2446-8006 ; 0000-0002-3260-0233</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,3026,27901,27902</link.rule.ids></links><search><creatorcontrib>Tas, Jeanette</creatorcontrib><creatorcontrib>Bos, Kirsten D. J.</creatorcontrib><creatorcontrib>Le Feber, Joost</creatorcontrib><creatorcontrib>Beqiri, Erta</creatorcontrib><creatorcontrib>Czosnyka, Marek</creatorcontrib><creatorcontrib>Haeren, Roel</creatorcontrib><creatorcontrib>van der Horst, Iwan C. C.</creatorcontrib><creatorcontrib>van Kuijk, Sander M. J.</creatorcontrib><creatorcontrib>Strauch, Ulrich</creatorcontrib><creatorcontrib>Brady, Ken M.</creatorcontrib><creatorcontrib>Smielewski, Peter</creatorcontrib><creatorcontrib>Aries, Marcel J. H.</creatorcontrib><title>Inducing oscillations in positive end-expiratory pressure improves assessment of cerebrovascular pressure reactivity in patients with traumatic brain injury</title><title>Journal of applied physiology (1985)</title><description>Cerebral autoregulation assessment requires sufficient slow arterial blood pressure (ABP) waves. However, spontaneous ABP waves may be insufficient for reliable cerebral autoregulation estimations. Therefore, we applied a ventilator “sigh-function” to generate positive end-expiratory pressure oscillations that induce slow ABP waves. This method demonstrated a reduced variability of the pressure reactivity index, commonly used as continuous cerebral autoregulation measure in a traumatic brain injury population.
The cerebral pressure reactivity index (PRx), through intracranial pressure (ICP) measurements, informs clinicians about the cerebral autoregulation (CA) status in adult-sedated patients with traumatic brain injury (TBI). Using PRx in clinical practice is currently limited by variability over shorter monitoring periods. We applied an innovative method to reduce the PRx variability by ventilator-induced slow (1/min) positive end-expiratory pressure (PEEP) oscillations. We hypothesized that, as seen in a previous animal model, the PRx variability would be reduced by inducing slow arterial blood pressure (ABP) and ICP oscillations without other clinically relevant physiological changes. Patients with TBI were ventilated with a static PEEP for 30 min (PRx period) followed by a 30-min period of slow [1/min (0.0167 Hz)] +5 cmH
2
O PEEP oscillations (induced ( iPRx period). Ten patients with TBI were included. No clinical monitoring was discontinued and no additional interventions were required during the iPRx period. The PRx variability [measured as the standard deviation (SD) of PRx] decreased significantly during the iPRx period from 0.25 (0.22–0.30) to 0.14 (0.09–0.17) ( P = 0.006). There was a power increase around the induced frequency (1/min) for both ABP and ICP ( P = 0.002). In conclusion, 1/min PEEP-induced oscillations reduced the PRx variability in patients with TBI with ICP levels <22 mmHg. No other clinically relevant physiological changes were observed. Reduced PRx variability might improve CA-guided perfusion management by reducing the time to find “optimal” perfusion pressure targets. Larger studies with prolonged periods of PEEP-induced oscillations are required to take it to routine use.
NEW & NOTEWORTHY Cerebral autoregulation assessment requires sufficient slow arterial blood pressure (ABP) waves. However, spontaneous ABP waves may be insufficient for reliable cerebral autoregulation estimations. Therefore, we applied a ventilator “sigh-function” to generate positive end-expiratory pressure oscillations that induce slow ABP waves. This method demonstrated a reduced variability of the pressure reactivity index, commonly used as continuous cerebral autoregulation measure in a traumatic brain injury population.</description><subject>Animal models</subject><subject>Blood pressure</subject><subject>Brain</subject><subject>Head injuries</subject><subject>Injury prevention</subject><subject>Innovative Methodology</subject><subject>Intracranial pressure</subject><subject>Monitoring</subject><subject>Oscillations</subject><subject>Patients</subject><subject>Perfusion</subject><subject>Physiology</subject><subject>Telemedicine</subject><subject>Traumatic brain injury</subject><subject>Variability</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpdkstu1TAQhi1ERU8Lz4AlNmxy8CWO4w0SqoBWqsSGri3HmdPjo8QOnuRA3qUPW_cibquR5v_mn7H1E_KWsy3nSnw4uGkapv2KIQ1bxrgxW8GEeEE2RRUVbxh_STatVqzSqtWn5AzxULi6VvwVOZVKm6bhckPurmK_-BBvaUIfhsHNIUWkIdIpYZjDESjEvoJfU8huTnmlUwbEJQMN45TTEZA6xNIaIc407aiHDF0RHPplcPkPn8H5Yhjm9dG-bCoTSH-GeU_n7JaxdDztsitqiIclr6_Jyc4NCG-e6zm5-fL5-8Vldf3t69XFp-vK10LMFe8UU0ozKZTv-hocSA6tVF3PoRCd463uRF2LXpqmbbnRyjS-4b4z3ku3k-fk45PvtHQj9L7cld1gpxxGl1ebXLD_KjHs7W06WlPXrZS6GLx_NsjpxwI42zGgh_KdEdKCVjRtw8pS3Rb03X_oIS05ludZoZnRjTSmLpR-onxOiBl2v4_hzD4kwP6dAPuYAPuQAHkPdeqtuA</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>Tas, Jeanette</creator><creator>Bos, Kirsten D. J.</creator><creator>Le Feber, Joost</creator><creator>Beqiri, Erta</creator><creator>Czosnyka, Marek</creator><creator>Haeren, Roel</creator><creator>van der Horst, Iwan C. C.</creator><creator>van Kuijk, Sander M. J.</creator><creator>Strauch, Ulrich</creator><creator>Brady, Ken M.</creator><creator>Smielewski, Peter</creator><creator>Aries, Marcel J. H.</creator><general>American Physiological Society</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8108-0000</orcidid><orcidid>https://orcid.org/0000-0003-2796-729X</orcidid><orcidid>https://orcid.org/0000-0001-5327-1275</orcidid><orcidid>https://orcid.org/0000-0002-0605-1437</orcidid><orcidid>https://orcid.org/0000-0001-5096-3938</orcidid><orcidid>https://orcid.org/0000-0002-8914-0960</orcidid><orcidid>https://orcid.org/0000-0003-1640-5013</orcidid><orcidid>https://orcid.org/0000-0003-3891-8522</orcidid><orcidid>https://orcid.org/0000-0003-2446-8006</orcidid><orcidid>https://orcid.org/0000-0002-3260-0233</orcidid></search><sort><creationdate>20220901</creationdate><title>Inducing oscillations in positive end-expiratory pressure improves assessment of cerebrovascular pressure reactivity in patients with traumatic brain injury</title><author>Tas, Jeanette ; Bos, Kirsten D. J. ; Le Feber, Joost ; Beqiri, Erta ; Czosnyka, Marek ; Haeren, Roel ; van der Horst, Iwan C. C. ; van Kuijk, Sander M. J. ; Strauch, Ulrich ; Brady, Ken M. ; Smielewski, Peter ; Aries, Marcel J. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-1b505570325cbd4eae31e835bd1ec42ba187b2442d39688197596c61cb9cc3af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animal models</topic><topic>Blood pressure</topic><topic>Brain</topic><topic>Head injuries</topic><topic>Injury prevention</topic><topic>Innovative Methodology</topic><topic>Intracranial pressure</topic><topic>Monitoring</topic><topic>Oscillations</topic><topic>Patients</topic><topic>Perfusion</topic><topic>Physiology</topic><topic>Telemedicine</topic><topic>Traumatic brain injury</topic><topic>Variability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tas, Jeanette</creatorcontrib><creatorcontrib>Bos, Kirsten D. J.</creatorcontrib><creatorcontrib>Le Feber, Joost</creatorcontrib><creatorcontrib>Beqiri, Erta</creatorcontrib><creatorcontrib>Czosnyka, Marek</creatorcontrib><creatorcontrib>Haeren, Roel</creatorcontrib><creatorcontrib>van der Horst, Iwan C. C.</creatorcontrib><creatorcontrib>van Kuijk, Sander M. J.</creatorcontrib><creatorcontrib>Strauch, Ulrich</creatorcontrib><creatorcontrib>Brady, Ken M.</creatorcontrib><creatorcontrib>Smielewski, Peter</creatorcontrib><creatorcontrib>Aries, Marcel J. H.</creatorcontrib><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tas, Jeanette</au><au>Bos, Kirsten D. J.</au><au>Le Feber, Joost</au><au>Beqiri, Erta</au><au>Czosnyka, Marek</au><au>Haeren, Roel</au><au>van der Horst, Iwan C. C.</au><au>van Kuijk, Sander M. J.</au><au>Strauch, Ulrich</au><au>Brady, Ken M.</au><au>Smielewski, Peter</au><au>Aries, Marcel J. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inducing oscillations in positive end-expiratory pressure improves assessment of cerebrovascular pressure reactivity in patients with traumatic brain injury</atitle><jtitle>Journal of applied physiology (1985)</jtitle><date>2022-09-01</date><risdate>2022</risdate><volume>133</volume><issue>3</issue><spage>585</spage><epage>592</epage><pages>585-592</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><abstract>Cerebral autoregulation assessment requires sufficient slow arterial blood pressure (ABP) waves. However, spontaneous ABP waves may be insufficient for reliable cerebral autoregulation estimations. Therefore, we applied a ventilator “sigh-function” to generate positive end-expiratory pressure oscillations that induce slow ABP waves. This method demonstrated a reduced variability of the pressure reactivity index, commonly used as continuous cerebral autoregulation measure in a traumatic brain injury population.
The cerebral pressure reactivity index (PRx), through intracranial pressure (ICP) measurements, informs clinicians about the cerebral autoregulation (CA) status in adult-sedated patients with traumatic brain injury (TBI). Using PRx in clinical practice is currently limited by variability over shorter monitoring periods. We applied an innovative method to reduce the PRx variability by ventilator-induced slow (1/min) positive end-expiratory pressure (PEEP) oscillations. We hypothesized that, as seen in a previous animal model, the PRx variability would be reduced by inducing slow arterial blood pressure (ABP) and ICP oscillations without other clinically relevant physiological changes. Patients with TBI were ventilated with a static PEEP for 30 min (PRx period) followed by a 30-min period of slow [1/min (0.0167 Hz)] +5 cmH
2
O PEEP oscillations (induced ( iPRx period). Ten patients with TBI were included. No clinical monitoring was discontinued and no additional interventions were required during the iPRx period. The PRx variability [measured as the standard deviation (SD) of PRx] decreased significantly during the iPRx period from 0.25 (0.22–0.30) to 0.14 (0.09–0.17) ( P = 0.006). There was a power increase around the induced frequency (1/min) for both ABP and ICP ( P = 0.002). In conclusion, 1/min PEEP-induced oscillations reduced the PRx variability in patients with TBI with ICP levels <22 mmHg. No other clinically relevant physiological changes were observed. Reduced PRx variability might improve CA-guided perfusion management by reducing the time to find “optimal” perfusion pressure targets. Larger studies with prolonged periods of PEEP-induced oscillations are required to take it to routine use.
NEW & NOTEWORTHY Cerebral autoregulation assessment requires sufficient slow arterial blood pressure (ABP) waves. However, spontaneous ABP waves may be insufficient for reliable cerebral autoregulation estimations. Therefore, we applied a ventilator “sigh-function” to generate positive end-expiratory pressure oscillations that induce slow ABP waves. This method demonstrated a reduced variability of the pressure reactivity index, commonly used as continuous cerebral autoregulation measure in a traumatic brain injury population.</abstract><cop>Bethesda</cop><pub>American Physiological Society</pub><pmid>35796613</pmid><doi>10.1152/japplphysiol.00199.2022</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8108-0000</orcidid><orcidid>https://orcid.org/0000-0003-2796-729X</orcidid><orcidid>https://orcid.org/0000-0001-5327-1275</orcidid><orcidid>https://orcid.org/0000-0002-0605-1437</orcidid><orcidid>https://orcid.org/0000-0001-5096-3938</orcidid><orcidid>https://orcid.org/0000-0002-8914-0960</orcidid><orcidid>https://orcid.org/0000-0003-1640-5013</orcidid><orcidid>https://orcid.org/0000-0003-3891-8522</orcidid><orcidid>https://orcid.org/0000-0003-2446-8006</orcidid><orcidid>https://orcid.org/0000-0002-3260-0233</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8750-7587 |
| ispartof | Journal of applied physiology (1985), 2022-09, Vol.133 (3), p.585-592 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9448337 |
| source | American Physiological Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animal models Blood pressure Brain Head injuries Injury prevention Innovative Methodology Intracranial pressure Monitoring Oscillations Patients Perfusion Physiology Telemedicine Traumatic brain injury Variability |
| title | Inducing oscillations in positive end-expiratory pressure improves assessment of cerebrovascular pressure reactivity in patients with traumatic brain injury |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T16%3A57%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inducing%20oscillations%20in%20positive%20end-expiratory%20pressure%20improves%20assessment%20of%20cerebrovascular%20pressure%20reactivity%20in%20patients%20with%20traumatic%20brain%20injury&rft.jtitle=Journal%20of%20applied%20physiology%20(1985)&rft.au=Tas,%20Jeanette&rft.date=2022-09-01&rft.volume=133&rft.issue=3&rft.spage=585&rft.epage=592&rft.pages=585-592&rft.issn=8750-7587&rft.eissn=1522-1601&rft_id=info:doi/10.1152/japplphysiol.00199.2022&rft_dat=%3Cproquest_pubme%3E2709763994%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2709763994&rft_id=info:pmid/35796613&rfr_iscdi=true |