GSTT1 and GSTM1 polymorphism in cigarette smokers with head and neck squamous cell carcinoma
Gene variability related to carcinogen activation and detoxification may interfere with susceptibility to head and neck cancer. To investigate the relation between GSTT1 and GSTM1 null polymorphisms and the risk of head and neck squamous cell carcinoma in cigarette smokers. A case-control study cond...
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| Veröffentlicht in: | Brazilian journal of otorhinolaryngology 2006-09, Vol.72 (5), p.654-658 |
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| container_title | Brazilian journal of otorhinolaryngology |
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| creator | Biselli, Joice Matos de Angelo Calsaverini Leal, Renata Cristina Ruiz, Mariângela Torreglosa Goloni-Bertollo, Eny Maria Maníglia, José Victor Rossit, Andréa Regina Baptista Pavarino-Bertelli, Érika Cristina |
| description | Gene variability related to carcinogen activation and detoxification may interfere with susceptibility to head and neck cancer.
To investigate the relation between GSTT1 and GSTM1 null polymorphisms and the risk of head and neck squamous cell carcinoma in cigarette smokers.
A case-control study conducted at the Sao Jose do Rio Preto Medical School, Brazil. GSTM1 and GSTT1 null genotype frequencies were evaluated by multiplex PCR in 45 cigarette smokers with head and neck squamous cell carcinomas and 45 cigarette smokers without this disease.
The oral cavity was the most prevalent tumor site for squamous cell carcinoma. The GSTT1 null genotype was found in 33.3% of the Experimental Group and 23.3% of the Control Group (p= 0.311). Experimental and Control Groups had GSTM1 null genotype frequencies of 35% and 48.3% (p=0.582). No association between alcohol consumption and GSTT1 and GSTMI null genotypes was found in these groups (p-values>0.05). There were more men, and alcohol consumption was prevalent in both groups.
In this study we were unable to show a correlation between GSTM1 and GSTT1 genotypes and the development of head and neck squamous cell carcinomas in cigarette smokers. |
| doi_str_mv | 10.1016/S1808-8694(15)31022-3 |
| format | Article |
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To investigate the relation between GSTT1 and GSTM1 null polymorphisms and the risk of head and neck squamous cell carcinoma in cigarette smokers.
A case-control study conducted at the Sao Jose do Rio Preto Medical School, Brazil. GSTM1 and GSTT1 null genotype frequencies were evaluated by multiplex PCR in 45 cigarette smokers with head and neck squamous cell carcinomas and 45 cigarette smokers without this disease.
The oral cavity was the most prevalent tumor site for squamous cell carcinoma. The GSTT1 null genotype was found in 33.3% of the Experimental Group and 23.3% of the Control Group (p= 0.311). Experimental and Control Groups had GSTM1 null genotype frequencies of 35% and 48.3% (p=0.582). No association between alcohol consumption and GSTT1 and GSTMI null genotypes was found in these groups (p-values>0.05). There were more men, and alcohol consumption was prevalent in both groups.
In this study we were unable to show a correlation between GSTM1 and GSTT1 genotypes and the development of head and neck squamous cell carcinomas in cigarette smokers.</description><identifier>ISSN: 1808-8694</identifier><identifier>EISSN: 1808-8686</identifier><identifier>DOI: 10.1016/S1808-8694(15)31022-3</identifier><identifier>PMID: 17221058</identifier><language>eng</language><publisher>Brazil: Elsevier Editora Ltda</publisher><subject>Alcohol ; Carcinoma, Squamous Cell - enzymology ; Carcinoma, Squamous Cell - etiology ; Carcinoma, Squamous Cell - genetics ; Case-Control Studies ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Glutathione transferase ; Glutathione Transferase - genetics ; Head and neck neoplasms ; Head and Neck Neoplasms - enzymology ; Head and Neck Neoplasms - etiology ; Head and Neck Neoplasms - genetics ; Humans ; Male ; Middle Aged ; Original ; Polymorphism ; Polymorphism, Genetic ; Risk Factors ; Smoking - adverse effects ; Smoking - genetics ; Tobacco</subject><ispartof>Brazilian journal of otorhinolaryngology, 2006-09, Vol.72 (5), p.654-658</ispartof><rights>2006 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial</rights><rights>Neck Surgery Department at the Sao Jose do Rio Preto Medical School - FAMERP. 2006 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3803-41174b8c3d49cee13a87cc70633072da0d296534bbe3993f40343879463351df3</citedby><cites>FETCH-LOGICAL-c3803-41174b8c3d49cee13a87cc70633072da0d296534bbe3993f40343879463351df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9443562/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9443562/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17221058$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Biselli, Joice Matos</creatorcontrib><creatorcontrib>de Angelo Calsaverini Leal, Renata Cristina</creatorcontrib><creatorcontrib>Ruiz, Mariângela Torreglosa</creatorcontrib><creatorcontrib>Goloni-Bertollo, Eny Maria</creatorcontrib><creatorcontrib>Maníglia, José Victor</creatorcontrib><creatorcontrib>Rossit, Andréa Regina Baptista</creatorcontrib><creatorcontrib>Pavarino-Bertelli, Érika Cristina</creatorcontrib><title>GSTT1 and GSTM1 polymorphism in cigarette smokers with head and neck squamous cell carcinoma</title><title>Brazilian journal of otorhinolaryngology</title><addtitle>Braz J Otorhinolaryngol</addtitle><description>Gene variability related to carcinogen activation and detoxification may interfere with susceptibility to head and neck cancer.
To investigate the relation between GSTT1 and GSTM1 null polymorphisms and the risk of head and neck squamous cell carcinoma in cigarette smokers.
A case-control study conducted at the Sao Jose do Rio Preto Medical School, Brazil. GSTM1 and GSTT1 null genotype frequencies were evaluated by multiplex PCR in 45 cigarette smokers with head and neck squamous cell carcinomas and 45 cigarette smokers without this disease.
The oral cavity was the most prevalent tumor site for squamous cell carcinoma. The GSTT1 null genotype was found in 33.3% of the Experimental Group and 23.3% of the Control Group (p= 0.311). Experimental and Control Groups had GSTM1 null genotype frequencies of 35% and 48.3% (p=0.582). No association between alcohol consumption and GSTT1 and GSTMI null genotypes was found in these groups (p-values>0.05). There were more men, and alcohol consumption was prevalent in both groups.
In this study we were unable to show a correlation between GSTM1 and GSTT1 genotypes and the development of head and neck squamous cell carcinomas in cigarette smokers.</description><subject>Alcohol</subject><subject>Carcinoma, Squamous Cell - enzymology</subject><subject>Carcinoma, Squamous Cell - etiology</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Glutathione transferase</subject><subject>Glutathione Transferase - genetics</subject><subject>Head and neck neoplasms</subject><subject>Head and Neck Neoplasms - enzymology</subject><subject>Head and Neck Neoplasms - etiology</subject><subject>Head and Neck Neoplasms - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Risk Factors</subject><subject>Smoking - adverse effects</subject><subject>Smoking - genetics</subject><subject>Tobacco</subject><issn>1808-8694</issn><issn>1808-8686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9PAjEQxRujEUQ_gqZHPay22-5u96IxRNEE4wG8mTSlHaCyu8V2wfDtXf4E9eRpJjPvvcn8EDqn5JoSmt4MqCAiEmnOL2lyxSiJ44gdoPZuLNLDfZ_zFjoJ4YOQNCNZcoxaNItjShLRRu-9wXBIsaoMbroXiueuWJXOz6c2lNhWWNuJ8lDXgEPpZuAD_rL1FE9BmY2rAj3D4XOhSrcIWENRYK28tpUr1Sk6GqsiwNmudtDb48Ow-xT1X3vP3ft-pJkgLOKUZnwkNDM81wCUKZFpnZGUMZLFRhET52nC-GgELM_ZmBPGmchy3ggSasasg263ufPFqASjoaq9KuTc21L5lXTKyr-byk7lxC1lzjlL0rgJSLYB2rsQPIz3XkrkGrfc4JZrlpImcoNbssZ38fvwj2vHtxHcbQXQvL-04GXQFioNxnrQtTTO_nPiG1e-j5E</recordid><startdate>200609</startdate><enddate>200609</enddate><creator>Biselli, Joice Matos</creator><creator>de Angelo Calsaverini Leal, Renata Cristina</creator><creator>Ruiz, Mariângela Torreglosa</creator><creator>Goloni-Bertollo, Eny Maria</creator><creator>Maníglia, José Victor</creator><creator>Rossit, Andréa Regina Baptista</creator><creator>Pavarino-Bertelli, Érika Cristina</creator><general>Elsevier Editora Ltda</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>200609</creationdate><title>GSTT1 and GSTM1 polymorphism in cigarette smokers with head and neck squamous cell carcinoma</title><author>Biselli, Joice Matos ; de Angelo Calsaverini Leal, Renata Cristina ; Ruiz, Mariângela Torreglosa ; Goloni-Bertollo, Eny Maria ; Maníglia, José Victor ; Rossit, Andréa Regina Baptista ; Pavarino-Bertelli, Érika Cristina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3803-41174b8c3d49cee13a87cc70633072da0d296534bbe3993f40343879463351df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Alcohol</topic><topic>Carcinoma, Squamous Cell - enzymology</topic><topic>Carcinoma, Squamous Cell - etiology</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Glutathione transferase</topic><topic>Glutathione Transferase - genetics</topic><topic>Head and neck neoplasms</topic><topic>Head and Neck Neoplasms - enzymology</topic><topic>Head and Neck Neoplasms - etiology</topic><topic>Head and Neck Neoplasms - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Risk Factors</topic><topic>Smoking - adverse effects</topic><topic>Smoking - genetics</topic><topic>Tobacco</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Biselli, Joice Matos</creatorcontrib><creatorcontrib>de Angelo Calsaverini Leal, Renata Cristina</creatorcontrib><creatorcontrib>Ruiz, Mariângela Torreglosa</creatorcontrib><creatorcontrib>Goloni-Bertollo, Eny Maria</creatorcontrib><creatorcontrib>Maníglia, José Victor</creatorcontrib><creatorcontrib>Rossit, Andréa Regina Baptista</creatorcontrib><creatorcontrib>Pavarino-Bertelli, Érika Cristina</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Brazilian journal of otorhinolaryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Biselli, Joice Matos</au><au>de Angelo Calsaverini Leal, Renata Cristina</au><au>Ruiz, Mariângela Torreglosa</au><au>Goloni-Bertollo, Eny Maria</au><au>Maníglia, José Victor</au><au>Rossit, Andréa Regina Baptista</au><au>Pavarino-Bertelli, Érika Cristina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GSTT1 and GSTM1 polymorphism in cigarette smokers with head and neck squamous cell carcinoma</atitle><jtitle>Brazilian journal of otorhinolaryngology</jtitle><addtitle>Braz J Otorhinolaryngol</addtitle><date>2006-09</date><risdate>2006</risdate><volume>72</volume><issue>5</issue><spage>654</spage><epage>658</epage><pages>654-658</pages><issn>1808-8694</issn><eissn>1808-8686</eissn><abstract>Gene variability related to carcinogen activation and detoxification may interfere with susceptibility to head and neck cancer.
To investigate the relation between GSTT1 and GSTM1 null polymorphisms and the risk of head and neck squamous cell carcinoma in cigarette smokers.
A case-control study conducted at the Sao Jose do Rio Preto Medical School, Brazil. GSTM1 and GSTT1 null genotype frequencies were evaluated by multiplex PCR in 45 cigarette smokers with head and neck squamous cell carcinomas and 45 cigarette smokers without this disease.
The oral cavity was the most prevalent tumor site for squamous cell carcinoma. The GSTT1 null genotype was found in 33.3% of the Experimental Group and 23.3% of the Control Group (p= 0.311). Experimental and Control Groups had GSTM1 null genotype frequencies of 35% and 48.3% (p=0.582). No association between alcohol consumption and GSTT1 and GSTMI null genotypes was found in these groups (p-values>0.05). There were more men, and alcohol consumption was prevalent in both groups.
In this study we were unable to show a correlation between GSTM1 and GSTT1 genotypes and the development of head and neck squamous cell carcinomas in cigarette smokers.</abstract><cop>Brazil</cop><pub>Elsevier Editora Ltda</pub><pmid>17221058</pmid><doi>10.1016/S1808-8694(15)31022-3</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Brazilian journal of otorhinolaryngology, 2006-09, Vol.72 (5), p.654-658 |
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| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Alcohol Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - etiology Carcinoma, Squamous Cell - genetics Case-Control Studies Female Gene Frequency Genetic Predisposition to Disease Genotype Glutathione transferase Glutathione Transferase - genetics Head and neck neoplasms Head and Neck Neoplasms - enzymology Head and Neck Neoplasms - etiology Head and Neck Neoplasms - genetics Humans Male Middle Aged Original Polymorphism Polymorphism, Genetic Risk Factors Smoking - adverse effects Smoking - genetics Tobacco |
| title | GSTT1 and GSTM1 polymorphism in cigarette smokers with head and neck squamous cell carcinoma |
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