P03.05.A Radiation-induced leukoencephalopathy (RIL) in glioma: unique injury dynamics following proton vs photon beam radiotherapy
Abstract Background White matter injury after brain-directed radiotherapy (RT), aka radiation-induced leukoencephalopathy (RIL), is common in brain tumor patients. Differentiation from progressive disease can be challenging. Dosimetric advantages of protons (PRT) over photons (XRT) minimize radiatio...
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| Veröffentlicht in: | Neuro-oncology (Charlottesville, Va.) Va.), 2022-09, Vol.24 (Supplement_2), p.ii33-ii33 |
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| creator | Winter, S F Gardner, M Parsons, M W Grassberger, C Bussière, M Kaul, D Boehmerle, W Endres, M Shih, H A Dietrich, J |
| description | Abstract
Background
White matter injury after brain-directed radiotherapy (RT), aka radiation-induced leukoencephalopathy (RIL), is common in brain tumor patients. Differentiation from progressive disease can be challenging. Dosimetric advantages of protons (PRT) over photons (XRT) minimize radiation to healthy brain tissue, potentially limiting radiotoxic sequelae including RIL. We characterized RIL during periods of progression-free survival (PFS) in glioma patients irradiated with either PRT or XRT, hypothesizing that PRT would result in reduced RIL outside of the target field.
Material and Methods
34 patients (19 male; mean age = 40.10y) with grade 2/3 gliomas and a history of partial cranial RT were stratified by RT modality [XRT (n=17) vs PRT (n=17)] and matched on 11 criteria [age, sex, tumor type/location/laterality, mutational status (IDH; 1p19q deletion), concurrent/adjuvant chemotherapy, radiation dose/fractions] for retrospective analysis. RIL development was characterized longitudinally for up to 3 years post-RT via analysis of serial MRI T2/FLAIR sequences. A novel RIL scoring system with embedded Fazekas scale was designed to quantify injury severity at both global (whole brain) and hemispheric levels.
Results
Matched groups did not differ significantly on any demographic or clinical characteristics. Median PFS post-RT was 4.7 (XRT) and 5.1 (PRT) years. The novel RIL scoring system was reliable (intraclass correlation coefficient >0.9). There was a significant increase in global RIL in both XRT [F(3, 57)=8.63, p< .001] and PRT [F(3, 61)=4.69, p< .005] groups over time, relative to baseline (1-month post-RT). A majority [62% (XRT) and 72% (PRT)] developed moderate or severe RIL within 3 years, with the ipsilesional hemisphere more severely affected. Analysis of RIL injury dynamics (i.e., average % change between 1 and 3 years post-RT) at hemispheric level identified radiation modality-specific differences: XRT resulted in greater contralesional hemispheric injury than PRT [F(1, 31)=4.32, p |
| doi_str_mv | 10.1093/neuonc/noac174.109 |
| format | Article |
| fullrecord | <record><control><sourceid>oup_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9443107</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/neuonc/noac174.109</oup_id><sourcerecordid>10.1093/neuonc/noac174.109</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1809-d816b1f327c2a866b336490c96b031a3436ff7768df5712804a102e96c4128953</originalsourceid><addsrcrecordid>eNqNUctOwzAQtBBIlMIPcPIRDmn9SJyEA1JV8ahUCVTB2XIcp3FJbOMkRTnz46QPIXHjtLOzO7NaDQDXGE0wSunUqM4aOTVWSByHO-4EjHBEaBAljJ3uMQmSCMfn4KJpNggRHDE8At-viE5QNJnBlci1aLU1gTZ5J1UOK9V9WGWkcqWorBNt2cOb1WJ5C7WB60rbWtzBzujPTg3MpvM9zHsjai0bWNiqsl_arKHztrUGbhvoyj3KlKihH67ZtlReuP4SnBWiatTVsY7B--PD2_w5WL48LeazZSBxgtIgTzDLcEFJLIkYvsooZWGKZMoyRLGgIWVFEccsyYsoxiRBocCIqJTJcOjSiI7B_cHXdVmtcqlM60XFnde18D23QvO_E6NLvrZbnoYhxSgeDMjBQHrbNF4Vv1qM-C4HfsiBH3PYc2MQHES2c__Z_wHx5I_4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>P03.05.A Radiation-induced leukoencephalopathy (RIL) in glioma: unique injury dynamics following proton vs photon beam radiotherapy</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Winter, S F ; Gardner, M ; Parsons, M W ; Grassberger, C ; Bussière, M ; Kaul, D ; Boehmerle, W ; Endres, M ; Shih, H A ; Dietrich, J</creator><creatorcontrib>Winter, S F ; Gardner, M ; Parsons, M W ; Grassberger, C ; Bussière, M ; Kaul, D ; Boehmerle, W ; Endres, M ; Shih, H A ; Dietrich, J</creatorcontrib><description>Abstract
Background
White matter injury after brain-directed radiotherapy (RT), aka radiation-induced leukoencephalopathy (RIL), is common in brain tumor patients. Differentiation from progressive disease can be challenging. Dosimetric advantages of protons (PRT) over photons (XRT) minimize radiation to healthy brain tissue, potentially limiting radiotoxic sequelae including RIL. We characterized RIL during periods of progression-free survival (PFS) in glioma patients irradiated with either PRT or XRT, hypothesizing that PRT would result in reduced RIL outside of the target field.
Material and Methods
34 patients (19 male; mean age = 40.10y) with grade 2/3 gliomas and a history of partial cranial RT were stratified by RT modality [XRT (n=17) vs PRT (n=17)] and matched on 11 criteria [age, sex, tumor type/location/laterality, mutational status (IDH; 1p19q deletion), concurrent/adjuvant chemotherapy, radiation dose/fractions] for retrospective analysis. RIL development was characterized longitudinally for up to 3 years post-RT via analysis of serial MRI T2/FLAIR sequences. A novel RIL scoring system with embedded Fazekas scale was designed to quantify injury severity at both global (whole brain) and hemispheric levels.
Results
Matched groups did not differ significantly on any demographic or clinical characteristics. Median PFS post-RT was 4.7 (XRT) and 5.1 (PRT) years. The novel RIL scoring system was reliable (intraclass correlation coefficient >0.9). There was a significant increase in global RIL in both XRT [F(3, 57)=8.63, p< .001] and PRT [F(3, 61)=4.69, p< .005] groups over time, relative to baseline (1-month post-RT). A majority [62% (XRT) and 72% (PRT)] developed moderate or severe RIL within 3 years, with the ipsilesional hemisphere more severely affected. Analysis of RIL injury dynamics (i.e., average % change between 1 and 3 years post-RT) at hemispheric level identified radiation modality-specific differences: XRT resulted in greater contralesional hemispheric injury than PRT [F(1, 31)=4.32, p<.05]. This effect was not observed in ipsilesional hemispheres.
Conclusion
RIL is common in glioma patients and quantifiable by characteristic imaging features, including early onset post-RT, greater ipsilesional injury burden, and progression over time. RIL injury dynamics appear to be radiation modality-specific, whereby XRT causes greater delayed injury in the remote, contralesional hemisphere. These findings may reflect dosimetric differences between protons and photons. The impact of such sequelae on cognitive function is subject of current investigation.</description><identifier>ISSN: 1522-8517</identifier><identifier>EISSN: 1523-5866</identifier><identifier>DOI: 10.1093/neuonc/noac174.109</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>POSTER PRESENTATIONS</subject><ispartof>Neuro-oncology (Charlottesville, Va.), 2022-09, Vol.24 (Supplement_2), p.ii33-ii33</ispartof><rights>The Author(s) 2022. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9443107/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9443107/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Winter, S F</creatorcontrib><creatorcontrib>Gardner, M</creatorcontrib><creatorcontrib>Parsons, M W</creatorcontrib><creatorcontrib>Grassberger, C</creatorcontrib><creatorcontrib>Bussière, M</creatorcontrib><creatorcontrib>Kaul, D</creatorcontrib><creatorcontrib>Boehmerle, W</creatorcontrib><creatorcontrib>Endres, M</creatorcontrib><creatorcontrib>Shih, H A</creatorcontrib><creatorcontrib>Dietrich, J</creatorcontrib><title>P03.05.A Radiation-induced leukoencephalopathy (RIL) in glioma: unique injury dynamics following proton vs photon beam radiotherapy</title><title>Neuro-oncology (Charlottesville, Va.)</title><description>Abstract
Background
White matter injury after brain-directed radiotherapy (RT), aka radiation-induced leukoencephalopathy (RIL), is common in brain tumor patients. Differentiation from progressive disease can be challenging. Dosimetric advantages of protons (PRT) over photons (XRT) minimize radiation to healthy brain tissue, potentially limiting radiotoxic sequelae including RIL. We characterized RIL during periods of progression-free survival (PFS) in glioma patients irradiated with either PRT or XRT, hypothesizing that PRT would result in reduced RIL outside of the target field.
Material and Methods
34 patients (19 male; mean age = 40.10y) with grade 2/3 gliomas and a history of partial cranial RT were stratified by RT modality [XRT (n=17) vs PRT (n=17)] and matched on 11 criteria [age, sex, tumor type/location/laterality, mutational status (IDH; 1p19q deletion), concurrent/adjuvant chemotherapy, radiation dose/fractions] for retrospective analysis. RIL development was characterized longitudinally for up to 3 years post-RT via analysis of serial MRI T2/FLAIR sequences. A novel RIL scoring system with embedded Fazekas scale was designed to quantify injury severity at both global (whole brain) and hemispheric levels.
Results
Matched groups did not differ significantly on any demographic or clinical characteristics. Median PFS post-RT was 4.7 (XRT) and 5.1 (PRT) years. The novel RIL scoring system was reliable (intraclass correlation coefficient >0.9). There was a significant increase in global RIL in both XRT [F(3, 57)=8.63, p< .001] and PRT [F(3, 61)=4.69, p< .005] groups over time, relative to baseline (1-month post-RT). A majority [62% (XRT) and 72% (PRT)] developed moderate or severe RIL within 3 years, with the ipsilesional hemisphere more severely affected. Analysis of RIL injury dynamics (i.e., average % change between 1 and 3 years post-RT) at hemispheric level identified radiation modality-specific differences: XRT resulted in greater contralesional hemispheric injury than PRT [F(1, 31)=4.32, p<.05]. This effect was not observed in ipsilesional hemispheres.
Conclusion
RIL is common in glioma patients and quantifiable by characteristic imaging features, including early onset post-RT, greater ipsilesional injury burden, and progression over time. RIL injury dynamics appear to be radiation modality-specific, whereby XRT causes greater delayed injury in the remote, contralesional hemisphere. These findings may reflect dosimetric differences between protons and photons. The impact of such sequelae on cognitive function is subject of current investigation.</description><subject>POSTER PRESENTATIONS</subject><issn>1522-8517</issn><issn>1523-5866</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqNUctOwzAQtBBIlMIPcPIRDmn9SJyEA1JV8ahUCVTB2XIcp3FJbOMkRTnz46QPIXHjtLOzO7NaDQDXGE0wSunUqM4aOTVWSByHO-4EjHBEaBAljJ3uMQmSCMfn4KJpNggRHDE8At-viE5QNJnBlci1aLU1gTZ5J1UOK9V9WGWkcqWorBNt2cOb1WJ5C7WB60rbWtzBzujPTg3MpvM9zHsjai0bWNiqsl_arKHztrUGbhvoyj3KlKihH67ZtlReuP4SnBWiatTVsY7B--PD2_w5WL48LeazZSBxgtIgTzDLcEFJLIkYvsooZWGKZMoyRLGgIWVFEccsyYsoxiRBocCIqJTJcOjSiI7B_cHXdVmtcqlM60XFnde18D23QvO_E6NLvrZbnoYhxSgeDMjBQHrbNF4Vv1qM-C4HfsiBH3PYc2MQHES2c__Z_wHx5I_4</recordid><startdate>20220905</startdate><enddate>20220905</enddate><creator>Winter, S F</creator><creator>Gardner, M</creator><creator>Parsons, M W</creator><creator>Grassberger, C</creator><creator>Bussière, M</creator><creator>Kaul, D</creator><creator>Boehmerle, W</creator><creator>Endres, M</creator><creator>Shih, H A</creator><creator>Dietrich, J</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20220905</creationdate><title>P03.05.A Radiation-induced leukoencephalopathy (RIL) in glioma: unique injury dynamics following proton vs photon beam radiotherapy</title><author>Winter, S F ; Gardner, M ; Parsons, M W ; Grassberger, C ; Bussière, M ; Kaul, D ; Boehmerle, W ; Endres, M ; Shih, H A ; Dietrich, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1809-d816b1f327c2a866b336490c96b031a3436ff7768df5712804a102e96c4128953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>POSTER PRESENTATIONS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Winter, S F</creatorcontrib><creatorcontrib>Gardner, M</creatorcontrib><creatorcontrib>Parsons, M W</creatorcontrib><creatorcontrib>Grassberger, C</creatorcontrib><creatorcontrib>Bussière, M</creatorcontrib><creatorcontrib>Kaul, D</creatorcontrib><creatorcontrib>Boehmerle, W</creatorcontrib><creatorcontrib>Endres, M</creatorcontrib><creatorcontrib>Shih, H A</creatorcontrib><creatorcontrib>Dietrich, J</creatorcontrib><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuro-oncology (Charlottesville, Va.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Winter, S F</au><au>Gardner, M</au><au>Parsons, M W</au><au>Grassberger, C</au><au>Bussière, M</au><au>Kaul, D</au><au>Boehmerle, W</au><au>Endres, M</au><au>Shih, H A</au><au>Dietrich, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>P03.05.A Radiation-induced leukoencephalopathy (RIL) in glioma: unique injury dynamics following proton vs photon beam radiotherapy</atitle><jtitle>Neuro-oncology (Charlottesville, Va.)</jtitle><date>2022-09-05</date><risdate>2022</risdate><volume>24</volume><issue>Supplement_2</issue><spage>ii33</spage><epage>ii33</epage><pages>ii33-ii33</pages><issn>1522-8517</issn><eissn>1523-5866</eissn><abstract>Abstract
Background
White matter injury after brain-directed radiotherapy (RT), aka radiation-induced leukoencephalopathy (RIL), is common in brain tumor patients. Differentiation from progressive disease can be challenging. Dosimetric advantages of protons (PRT) over photons (XRT) minimize radiation to healthy brain tissue, potentially limiting radiotoxic sequelae including RIL. We characterized RIL during periods of progression-free survival (PFS) in glioma patients irradiated with either PRT or XRT, hypothesizing that PRT would result in reduced RIL outside of the target field.
Material and Methods
34 patients (19 male; mean age = 40.10y) with grade 2/3 gliomas and a history of partial cranial RT were stratified by RT modality [XRT (n=17) vs PRT (n=17)] and matched on 11 criteria [age, sex, tumor type/location/laterality, mutational status (IDH; 1p19q deletion), concurrent/adjuvant chemotherapy, radiation dose/fractions] for retrospective analysis. RIL development was characterized longitudinally for up to 3 years post-RT via analysis of serial MRI T2/FLAIR sequences. A novel RIL scoring system with embedded Fazekas scale was designed to quantify injury severity at both global (whole brain) and hemispheric levels.
Results
Matched groups did not differ significantly on any demographic or clinical characteristics. Median PFS post-RT was 4.7 (XRT) and 5.1 (PRT) years. The novel RIL scoring system was reliable (intraclass correlation coefficient >0.9). There was a significant increase in global RIL in both XRT [F(3, 57)=8.63, p< .001] and PRT [F(3, 61)=4.69, p< .005] groups over time, relative to baseline (1-month post-RT). A majority [62% (XRT) and 72% (PRT)] developed moderate or severe RIL within 3 years, with the ipsilesional hemisphere more severely affected. Analysis of RIL injury dynamics (i.e., average % change between 1 and 3 years post-RT) at hemispheric level identified radiation modality-specific differences: XRT resulted in greater contralesional hemispheric injury than PRT [F(1, 31)=4.32, p<.05]. This effect was not observed in ipsilesional hemispheres.
Conclusion
RIL is common in glioma patients and quantifiable by characteristic imaging features, including early onset post-RT, greater ipsilesional injury burden, and progression over time. RIL injury dynamics appear to be radiation modality-specific, whereby XRT causes greater delayed injury in the remote, contralesional hemisphere. These findings may reflect dosimetric differences between protons and photons. The impact of such sequelae on cognitive function is subject of current investigation.</abstract><cop>US</cop><pub>Oxford University Press</pub><doi>10.1093/neuonc/noac174.109</doi><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | POSTER PRESENTATIONS |
| title | P03.05.A Radiation-induced leukoencephalopathy (RIL) in glioma: unique injury dynamics following proton vs photon beam radiotherapy |
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