Lysosomal K+ channel TMEM175 promotes apoptosis and aggravates symptoms of Parkinson's disease

Lysosomes are degradative organelles and play vital roles in a variety of cellular processes. Ion channels on the lysosomal membrane are key regulators of lysosomal function. TMEM175 has been identified as a lysosomal potassium channel, but its modulation and physiological functions remain unclear....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	EMBO reports 2022-09, Vol.23 (9), p.e53234-n/a
Hauptverfasser:	Qu, Lili, Lin, Bingqian, Zeng, Wenping, Fan, Chunhong, Wu, Haotian, Ge, Yushu, Li, Qianqian, Li, Canjun, Wei, Yanan, Xin, Jing, Wang, Xingbing, Liu, Dan, Cang, Chunlei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Caspase Disease Models, Animal Dopamine receptors EMBO07 EMBO20 EMBO27 Feedback Feedback loops Homeostasis Ion channels lysosome Lysosomes Lysosomes - metabolism Mice Mice, Inbred C57BL Mitochondria Movement disorders MPTP Neurodegenerative diseases Neurons Organelles Parkinson Disease - genetics Parkinson Disease - metabolism Parkinson's disease Positive feedback Potassium potassium channel Potassium channels Potassium Channels - metabolism Proteins Proto-Oncogene Proteins c-bcl-2 - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Signal transduction Signs and symptoms Therapeutic targets TMEM175
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!