The Persistent Pain Transcriptome: Identification of Cells and Molecules Activated by Hyperalgesia

•We present the molecular response in dorsal spinal cord to peripheral inflammation.•Identify ALK as an induced neuronal tyrosine kinase receptor in dynorphinergic neurons.•Distinguish interferon immune responses from afferent driven complement increase.•Identify targetable analgesic signaling molec...

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Veröffentlicht in:	The journal of pain 2021-10, Vol.22 (10), p.1146-1179
Hauptverfasser:	Sapio, Matthew R., Kim, Jenny J., Loydpierson, Amelia J., Maric, Dragan, Goto, Taichi, Vazquez, Fernando A., Dougherty, Mary K., Narasimhan, Radhika, Muhly, Wallis T., Iadarola, Michael J., Mannes, Andrew J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaplastic Lymphoma Kinase - metabolism Animals Chronic Pain - immunology Chronic Pain - metabolism Disease Models, Animal Hyperalgesia - immunology Hyperalgesia - metabolism Neuroinflammatory Diseases - immunology Neuroinflammatory Diseases - metabolism opioids Peripheral Nerve Injuries - immunology Peripheral Nerve Injuries - metabolism persistent pain Posterior Horn Cells - immunology Posterior Horn Cells - metabolism Rats RNA-Seq Sequence Analysis, RNA spinal cord Transcriptome - physiology transcriptomics
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