Antioxidative and Anti-Inflammatory Protective Effects of β-Caryophyllene against Amikacin-Induced Nephrotoxicity in Rat by Regulating the Nrf2/AMPK/AKT and NF-κB/TGF-β/KIM-1 Molecular Pathways

Herein, the molecular pathogenic pathways implicated in renal injury triggered by amikacin (AK), together with the alleviating actions of β-caryophyllene (BCP), were investigated. Adult male Wistar rats (n=32) were disseminated to the four following groups (n=8/group): normal group, positive control...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2022, Vol.2022, p.4212331-12
Hauptverfasser:	Rajab, Bodour S., Albukhari, Talat A., Khan, Anmar A., Refaat, Bassem, Almehmadi, Samah J., Nasreldin, Nani, Elshopakey, Gehad E., El-Boshy, Mohamed
Format:	Artikel
Sprache:	eng
Schlagworte:	Amikacin - toxicity AMP-Activated Protein Kinases - metabolism Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Antibodies Antioxidants Antioxidants - pharmacology Apoptosis Automation Creatinine Free radicals Gene expression Hydrogen Peroxide - pharmacology Kidney - drug effects Kinases Male NF-E2-Related Factor 2 - metabolism NF-kappa B - metabolism Oxidative stress Polycyclic Sesquiterpenes - pharmacology Proliferating Cell Nuclear Antigen - metabolism Proteins Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Wistar Signal Transduction Transforming Growth Factor beta Tumor necrosis factor-TNF Urine
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