Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation

Opposing roles have been proposed for IL-22 in intestinal pathophysiology. We have optimized human small intestinal organoid (hSIO) culturing, constitutively generating all differentiated cell types while maintaining an active stem cell compartment. IL-22 does not promote the expansion of stem cells...

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Veröffentlicht in:	Cell stem cell 2022-09, Vol.29 (9), p.1333-1345.e6
Hauptverfasser:	He, Gui-Wei, Lin, Lin, DeMartino, Jeff, Zheng, Xuan, Staliarova, Nadzeya, Dayton, Talya, Begthel, Harry, van de Wetering, Willine J., Bodewes, Eduard, van Zon, Jeroen, Tans, Sander, Lopez-Iglesias, Carmen, Peters, Peter J., Wu, Wei, Kotlarz, Daniel, Klein, Christoph, Margaritis, Thanasis, Holstege, Frank, Clevers, Hans
Format:	Artikel
Sprache:	eng
Schlagworte:	anti-microbial proteins Calcium-Binding Proteins - metabolism DNA-Binding Proteins - metabolism enterocytes Humans IL-22 IL10RB inflammatory bowel disease Interleukin-22 Interleukins - metabolism Intestinal Mucosa - metabolism intestinal stem cells Intestine, Small - metabolism mTOR organoids Organoids - metabolism Paneth Cells regeneration Tumor Suppressor Proteins - metabolism
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