The Importance of Val386 in Transmembrane Domain 8 for the Activation of OATP1B3 by Epigallocatechin Gallate

Estrone-3-sulfate (E3S) uptake mediated by organic anion transporting polypeptide 1B3 (OATP1B3) can be activated by epigallocatechin gallate (EGCG). In this study, by using chimeric transporters and site-directed mutagenesis, we found that Val386 in transmembrane domain 8 (TM8) is essential for OATP...

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Veröffentlicht in:Journal of agricultural and food chemistry 2022-06, Vol.70 (21), p.6552-6560
Hauptverfasser: Wang, Zhongmin, Li, Ying, Villanueva, Cecilia E., Peng, Taotao, Han, Wanjun, Bo, Zheyue, Zhang, Hongjian, Hagenbuch, Bruno, Gui, Chunshan
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Sprache:eng
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