Hyperglycemia and Liver Ischemia Reperfusion Injury: A Role for the Advanced Glycation Endproduct and Its Receptor Pathway

Although pretransplant diabetes is a risk factor for mortality post–liver transplant, the underlying mechanism has not been fully defined. In a murine liver partial warm ischemia model, we addressed the question of how diabetes/hyperglycemia impacted tissue inflammatory injuries against ischemia rep...

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Veröffentlicht in:	American journal of transplantation 2015-11, Vol.15 (11), p.2877-2887
Hauptverfasser:	Yue, S., Zhou, H. M., Zhu, J. J., Rao, J. H., Busuttil, R. W., Kupiec‐Weglinski, J. W., Lu, L., Zhai, Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - metabolism Animals Biopsy, Needle Blotting, Western Cells, Cultured cytokines/cytokine receptors Diabetes Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - immunology Diabetes Mellitus, Experimental - pathology Enzyme-Linked Immunosorbent Assay Hepatocytes - cytology Hepatocytes - metabolism Hyperglycemia Hyperglycemia - complications immune/inflammatory Immunohistochemistry Injuries Ischemia Ischemia - metabolism Ischemia - pathology ischemia reperfusion injury (IRI) Kupffer Cells - cytology Kupffer Cells - metabolism Liver Liver - blood supply liver disease macrophage/monocyte biology: activation Macrophages - cytology Macrophages - metabolism Male Mice Mice, Inbred C57BL Random Allocation Real-Time Polymerase Chain Reaction - methods Receptor for Advanced Glycation End Products - metabolism Reperfusion Injury - metabolism Reperfusion Injury - pathology Rodents Signal Transduction Streptozocin - pharmacology
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