Functional convergence of on-off direction-selective ganglion cells in the visual thalamus
In the mouse visual system, multiple types of retinal ganglion cells (RGCs) each encode distinct features of the visual space. A clear understanding of how this information is parsed in their downstream target, the dorsal lateral geniculate nucleus (dLGN), remains elusive. Here, we characterized ret...
Gespeichert in:
| Veröffentlicht in: | Current biology 2022-07, Vol.32 (14), p.3110-3120.e6 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3120.e6 |
|---|---|
| container_issue | 14 |
| container_start_page | 3110 |
| container_title | Current biology |
| container_volume | 32 |
| creator | Jiang, Qiufen Litvina, Elizabeth Y. Acarón Ledesma, Héctor Shu, Guanhua Sonoda, Takuma Wei, Wei Chen, Chinfei |
| description | In the mouse visual system, multiple types of retinal ganglion cells (RGCs) each encode distinct features of the visual space. A clear understanding of how this information is parsed in their downstream target, the dorsal lateral geniculate nucleus (dLGN), remains elusive. Here, we characterized retinogeniculate connectivity in Cart-IRES2-Cre-D and BD-CreER2 mice, which labels subsets of on-off direction-selective ganglion cells (ooDSGCs) tuned to the vertical directions and to only ventral motion, respectively. Our immunohistochemical, electrophysiological, and optogenetic experiments reveal that only a small fraction ( |
| doi_str_mv | 10.1016/j.cub.2022.06.023 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9438454</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0960982222009824</els_id><sourcerecordid>2686055694</sourcerecordid><originalsourceid>FETCH-LOGICAL-c451t-7cfc001fdee7f4889cdb4c0e4f652f1e2dc07e7ded4f5c636ae763692f367703</originalsourceid><addsrcrecordid>eNp9kU1v3CAQhlHUqtmk_QG5VBx7sQMYg1GlStUqX1KkXnLqBbF42GXlhRRsS_n3wdkkai-9DCN4551hHoQuKKkpoeJyX9tpUzPCWE1ETVhzgla0k6oinLcf0IooQSrVMXaKznLeE0JZp8QndNq0UjWiIyv0-3oKdvQxmAHbGGZIWwgWcHQ4hio6h3uf4EVRZRiWbAa8NWE7lCtsYRgy9gGPO8Czz1OxGXdmMIcpf0YfnRkyfHk9z9HD9dXD-ra6_3Vzt_55X1ne0rGS1tkymesBpONdp2y_4ZYAd6JljgLrLZEge-i5a61ohAFZomKuEVKS5hz9ONo-TpsD9BbCmMygH5M_mPSko_H635fgd3obZ6140_GWF4NvrwYp_pkgj_rg8_IxEyBOWTPRCdK2Qi1SepTaFHNO4N7bUKIXJHqvCxK9INFE6IKk1Hz9e773ijcGRfD9KICypNlD0tn6BcJx87qP_j_2z3xPn20</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2686055694</pqid></control><display><type>article</type><title>Functional convergence of on-off direction-selective ganglion cells in the visual thalamus</title><source>MEDLINE</source><source>Cell Press Free Archives</source><source>ScienceDirect Journals (5 years ago - present)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Jiang, Qiufen ; Litvina, Elizabeth Y. ; Acarón Ledesma, Héctor ; Shu, Guanhua ; Sonoda, Takuma ; Wei, Wei ; Chen, Chinfei</creator><creatorcontrib>Jiang, Qiufen ; Litvina, Elizabeth Y. ; Acarón Ledesma, Héctor ; Shu, Guanhua ; Sonoda, Takuma ; Wei, Wei ; Chen, Chinfei</creatorcontrib><description>In the mouse visual system, multiple types of retinal ganglion cells (RGCs) each encode distinct features of the visual space. A clear understanding of how this information is parsed in their downstream target, the dorsal lateral geniculate nucleus (dLGN), remains elusive. Here, we characterized retinogeniculate connectivity in Cart-IRES2-Cre-D and BD-CreER2 mice, which labels subsets of on-off direction-selective ganglion cells (ooDSGCs) tuned to the vertical directions and to only ventral motion, respectively. Our immunohistochemical, electrophysiological, and optogenetic experiments reveal that only a small fraction (<15%) of thalamocortical (TC) neurons in the dLGN receives primary retinal drive from these subtypes of ooDSGCs. The majority of the functionally identifiable ooDSGC inputs in the dLGN are weak and converge together with inputs from other RGC types. Yet our modeling indicates that this mixing is not random: BD-CreER+ ooDSGC inputs converge less frequently with ooDSGCs tuned to the opposite direction than with non-CART-Cre+ RGC types. Taken together, these results indicate that convergence of distinct information lines in dLGN follows specific rules of organization.
[Display omitted]
•Most relay (TC) neurons innervated by ooDSGCs receive inputs from other RGC types•Only a small fraction of TC neurons are primarily driven by ooDSGCs•TC neurons tend not to receive both inputs from ventrally and dorsally tuned ooDSGCs
Jiang and Litvina et al. explore the rules of convergence among inputs from different types or subtypes of RGCs onto thalamocortical neurons in visual thalamus. They identify a specific wiring organization for on-off direction-selective retinal inputs. Their results show that distinct rules apply for RGC types versus subtypes.</description><identifier>ISSN: 0960-9822</identifier><identifier>ISSN: 1879-0445</identifier><identifier>EISSN: 1879-0445</identifier><identifier>DOI: 10.1016/j.cub.2022.06.023</identifier><identifier>PMID: 35793680</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Animals ; dorsal lateral geniculate nucleus ; Geniculate Bodies - physiology ; information processing ; labeled lines ; Mice ; on-off direction-selective ganglion cells ; Retina ; Retinal Ganglion Cells - physiology ; retinogeniculate synapse ; sensory integration ; Thalamus ; Visual Pathways - physiology</subject><ispartof>Current biology, 2022-07, Vol.32 (14), p.3110-3120.e6</ispartof><rights>2022 Elsevier Inc.</rights><rights>Copyright © 2022 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-7cfc001fdee7f4889cdb4c0e4f652f1e2dc07e7ded4f5c636ae763692f367703</citedby><cites>FETCH-LOGICAL-c451t-7cfc001fdee7f4889cdb4c0e4f652f1e2dc07e7ded4f5c636ae763692f367703</cites><orcidid>0000-0001-5121-9561 ; 0000-0002-8727-0171</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cub.2022.06.023$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35793680$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Qiufen</creatorcontrib><creatorcontrib>Litvina, Elizabeth Y.</creatorcontrib><creatorcontrib>Acarón Ledesma, Héctor</creatorcontrib><creatorcontrib>Shu, Guanhua</creatorcontrib><creatorcontrib>Sonoda, Takuma</creatorcontrib><creatorcontrib>Wei, Wei</creatorcontrib><creatorcontrib>Chen, Chinfei</creatorcontrib><title>Functional convergence of on-off direction-selective ganglion cells in the visual thalamus</title><title>Current biology</title><addtitle>Curr Biol</addtitle><description>In the mouse visual system, multiple types of retinal ganglion cells (RGCs) each encode distinct features of the visual space. A clear understanding of how this information is parsed in their downstream target, the dorsal lateral geniculate nucleus (dLGN), remains elusive. Here, we characterized retinogeniculate connectivity in Cart-IRES2-Cre-D and BD-CreER2 mice, which labels subsets of on-off direction-selective ganglion cells (ooDSGCs) tuned to the vertical directions and to only ventral motion, respectively. Our immunohistochemical, electrophysiological, and optogenetic experiments reveal that only a small fraction (<15%) of thalamocortical (TC) neurons in the dLGN receives primary retinal drive from these subtypes of ooDSGCs. The majority of the functionally identifiable ooDSGC inputs in the dLGN are weak and converge together with inputs from other RGC types. Yet our modeling indicates that this mixing is not random: BD-CreER+ ooDSGC inputs converge less frequently with ooDSGCs tuned to the opposite direction than with non-CART-Cre+ RGC types. Taken together, these results indicate that convergence of distinct information lines in dLGN follows specific rules of organization.
[Display omitted]
•Most relay (TC) neurons innervated by ooDSGCs receive inputs from other RGC types•Only a small fraction of TC neurons are primarily driven by ooDSGCs•TC neurons tend not to receive both inputs from ventrally and dorsally tuned ooDSGCs
Jiang and Litvina et al. explore the rules of convergence among inputs from different types or subtypes of RGCs onto thalamocortical neurons in visual thalamus. They identify a specific wiring organization for on-off direction-selective retinal inputs. Their results show that distinct rules apply for RGC types versus subtypes.</description><subject>Animals</subject><subject>dorsal lateral geniculate nucleus</subject><subject>Geniculate Bodies - physiology</subject><subject>information processing</subject><subject>labeled lines</subject><subject>Mice</subject><subject>on-off direction-selective ganglion cells</subject><subject>Retina</subject><subject>Retinal Ganglion Cells - physiology</subject><subject>retinogeniculate synapse</subject><subject>sensory integration</subject><subject>Thalamus</subject><subject>Visual Pathways - physiology</subject><issn>0960-9822</issn><issn>1879-0445</issn><issn>1879-0445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v3CAQhlHUqtmk_QG5VBx7sQMYg1GlStUqX1KkXnLqBbF42GXlhRRsS_n3wdkkai-9DCN4551hHoQuKKkpoeJyX9tpUzPCWE1ETVhzgla0k6oinLcf0IooQSrVMXaKznLeE0JZp8QndNq0UjWiIyv0-3oKdvQxmAHbGGZIWwgWcHQ4hio6h3uf4EVRZRiWbAa8NWE7lCtsYRgy9gGPO8Czz1OxGXdmMIcpf0YfnRkyfHk9z9HD9dXD-ra6_3Vzt_55X1ne0rGS1tkymesBpONdp2y_4ZYAd6JljgLrLZEge-i5a61ohAFZomKuEVKS5hz9ONo-TpsD9BbCmMygH5M_mPSko_H635fgd3obZ6140_GWF4NvrwYp_pkgj_rg8_IxEyBOWTPRCdK2Qi1SepTaFHNO4N7bUKIXJHqvCxK9INFE6IKk1Hz9e773ijcGRfD9KICypNlD0tn6BcJx87qP_j_2z3xPn20</recordid><startdate>20220725</startdate><enddate>20220725</enddate><creator>Jiang, Qiufen</creator><creator>Litvina, Elizabeth Y.</creator><creator>Acarón Ledesma, Héctor</creator><creator>Shu, Guanhua</creator><creator>Sonoda, Takuma</creator><creator>Wei, Wei</creator><creator>Chen, Chinfei</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5121-9561</orcidid><orcidid>https://orcid.org/0000-0002-8727-0171</orcidid></search><sort><creationdate>20220725</creationdate><title>Functional convergence of on-off direction-selective ganglion cells in the visual thalamus</title><author>Jiang, Qiufen ; Litvina, Elizabeth Y. ; Acarón Ledesma, Héctor ; Shu, Guanhua ; Sonoda, Takuma ; Wei, Wei ; Chen, Chinfei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-7cfc001fdee7f4889cdb4c0e4f652f1e2dc07e7ded4f5c636ae763692f367703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>dorsal lateral geniculate nucleus</topic><topic>Geniculate Bodies - physiology</topic><topic>information processing</topic><topic>labeled lines</topic><topic>Mice</topic><topic>on-off direction-selective ganglion cells</topic><topic>Retina</topic><topic>Retinal Ganglion Cells - physiology</topic><topic>retinogeniculate synapse</topic><topic>sensory integration</topic><topic>Thalamus</topic><topic>Visual Pathways - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Qiufen</creatorcontrib><creatorcontrib>Litvina, Elizabeth Y.</creatorcontrib><creatorcontrib>Acarón Ledesma, Héctor</creatorcontrib><creatorcontrib>Shu, Guanhua</creatorcontrib><creatorcontrib>Sonoda, Takuma</creatorcontrib><creatorcontrib>Wei, Wei</creatorcontrib><creatorcontrib>Chen, Chinfei</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Qiufen</au><au>Litvina, Elizabeth Y.</au><au>Acarón Ledesma, Héctor</au><au>Shu, Guanhua</au><au>Sonoda, Takuma</au><au>Wei, Wei</au><au>Chen, Chinfei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional convergence of on-off direction-selective ganglion cells in the visual thalamus</atitle><jtitle>Current biology</jtitle><addtitle>Curr Biol</addtitle><date>2022-07-25</date><risdate>2022</risdate><volume>32</volume><issue>14</issue><spage>3110</spage><epage>3120.e6</epage><pages>3110-3120.e6</pages><issn>0960-9822</issn><issn>1879-0445</issn><eissn>1879-0445</eissn><abstract>In the mouse visual system, multiple types of retinal ganglion cells (RGCs) each encode distinct features of the visual space. A clear understanding of how this information is parsed in their downstream target, the dorsal lateral geniculate nucleus (dLGN), remains elusive. Here, we characterized retinogeniculate connectivity in Cart-IRES2-Cre-D and BD-CreER2 mice, which labels subsets of on-off direction-selective ganglion cells (ooDSGCs) tuned to the vertical directions and to only ventral motion, respectively. Our immunohistochemical, electrophysiological, and optogenetic experiments reveal that only a small fraction (<15%) of thalamocortical (TC) neurons in the dLGN receives primary retinal drive from these subtypes of ooDSGCs. The majority of the functionally identifiable ooDSGC inputs in the dLGN are weak and converge together with inputs from other RGC types. Yet our modeling indicates that this mixing is not random: BD-CreER+ ooDSGC inputs converge less frequently with ooDSGCs tuned to the opposite direction than with non-CART-Cre+ RGC types. Taken together, these results indicate that convergence of distinct information lines in dLGN follows specific rules of organization.
[Display omitted]
•Most relay (TC) neurons innervated by ooDSGCs receive inputs from other RGC types•Only a small fraction of TC neurons are primarily driven by ooDSGCs•TC neurons tend not to receive both inputs from ventrally and dorsally tuned ooDSGCs
Jiang and Litvina et al. explore the rules of convergence among inputs from different types or subtypes of RGCs onto thalamocortical neurons in visual thalamus. They identify a specific wiring organization for on-off direction-selective retinal inputs. Their results show that distinct rules apply for RGC types versus subtypes.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>35793680</pmid><doi>10.1016/j.cub.2022.06.023</doi><orcidid>https://orcid.org/0000-0001-5121-9561</orcidid><orcidid>https://orcid.org/0000-0002-8727-0171</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-9822 |
| ispartof | Current biology, 2022-07, Vol.32 (14), p.3110-3120.e6 |
| issn | 0960-9822 1879-0445 1879-0445 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9438454 |
| source | MEDLINE; Cell Press Free Archives; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals dorsal lateral geniculate nucleus Geniculate Bodies - physiology information processing labeled lines Mice on-off direction-selective ganglion cells Retina Retinal Ganglion Cells - physiology retinogeniculate synapse sensory integration Thalamus Visual Pathways - physiology |
| title | Functional convergence of on-off direction-selective ganglion cells in the visual thalamus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T21%3A16%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Functional%20convergence%20of%20on-off%20direction-selective%20ganglion%20cells%20in%20the%20visual%20thalamus&rft.jtitle=Current%20biology&rft.au=Jiang,%20Qiufen&rft.date=2022-07-25&rft.volume=32&rft.issue=14&rft.spage=3110&rft.epage=3120.e6&rft.pages=3110-3120.e6&rft.issn=0960-9822&rft.eissn=1879-0445&rft_id=info:doi/10.1016/j.cub.2022.06.023&rft_dat=%3Cproquest_pubme%3E2686055694%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2686055694&rft_id=info:pmid/35793680&rft_els_id=S0960982222009824&rfr_iscdi=true |