Targeting the DNA Damage Response Pathways and Replication Stress in Colorectal Cancer

Genomic instability is a hallmark of cancer and targeting DNA damage response (DDR) is emerging as a promising therapeutic strategy in different solid tumors. The effectiveness of targeting DDR in colorectal cancer has not been extensively explored. We challenged 112 cell models recapitulating the g...

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Veröffentlicht in:	Clinical cancer research 2022-09, Vol.28 (17), p.3874-3889
Hauptverfasser:	Durinikova, Erika, Reilly, Nicole M, Buzo, Kristi, Mariella, Elisa, Chilà, Rosaria, Lorenzato, Annalisa, Dias, João M L, Grasso, Gaia, Pisati, Federica, Lamba, Simona, Corti, Giorgio, Degasperi, Andrea, Cancelliere, Carlotta, Mauri, Gianluca, Andrei, Pietro, Linnebacher, Michael, Marsoni, Silvia, Siena, Salvatore, Sartore-Bianchi, Andrea, Nik-Zainal, Serena, Di Nicolantonio, Federica, Bardelli, Alberto, Arena, Sabrina
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Ataxia Telangiectasia Mutated Proteins - genetics Ataxia Telangiectasia Mutated Proteins - metabolism Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics DNA Damage DNA Replication DNA-Activated Protein Kinase - genetics Humans Protein Kinase Inhibitors - pharmacology
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