Performance of Xpert HIV-1 viral load test in Senegal: a country of high circulation of CRF02_AG
Introductionthe introduction of the point-of-care in HIV-1 viral load quantification appears to be a complementary strategy to the existing conventional system of the acceleration plan for the achievement of the three 90s in Senegal. The objective of this study was to evaluate the performance of the...
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| Veröffentlicht in: | The Pan African medical journal 2022-06, Vol.42, p.136-136 |
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| creator | Séne, Pauline Yacine Diop-Ndiaye, Halimatou Ndoye, Aissatou Sow Kiernan, Brianan Coulibaly, Khadidiatou Ndiaye, Ousseynou Diallo, Sada Selbe Ndiaye, Anna Julienne Fall, Mengue Ba, Adjiratou Aissatou Camara, Makhtar Bouh Boye, Cheikh Saad Ngom, Ndeye Fatou Lejeune, Charlotte Ndour, Cheikh Tidiane Kane, Coumba Toure |
| description | Introductionthe introduction of the point-of-care in HIV-1 viral load quantification appears to be a complementary strategy to the existing conventional system of the acceleration plan for the achievement of the three 90s in Senegal. The objective of this study was to evaluate the performance of the Xpert® HIV-1 viral load in the context of circulation of non-B, non-C subtypes. Methodstwo hundred samples, were tested on Xpert® HIV-1 Viral Load using 1 ml of plasma in comparison to 600 μl on Abbott Real-time HIV-1 assay. The difference between viral load values was considered significant for Dlog |
| doi_str_mv | 10.11604/pamj.2022.42.136.32041 |
| format | Article |
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The objective of this study was to evaluate the performance of the Xpert® HIV-1 viral load in the context of circulation of non-B, non-C subtypes. Methodstwo hundred samples, were tested on Xpert® HIV-1 Viral Load using 1 ml of plasma in comparison to 600 μl on Abbott Real-time HIV-1 assay. The difference between viral load values was considered significant for Dlog <0.5 log copies/ml. Resultsa good correlation (r=0.985) was noted and confirmed using passing-bablok regression (slope 1.048; 95% CI: 1.036 to 1.069) for 188 samples with samples. A mean difference of 0.0075 log10 copies/ml for a 95% confidence interval (CI) of 0.002 log10 copies/ml to 0.013 log10 copies/ml was obtained. Sensitivity and specificity were respectively 93.6% and 93.5% at the threshold of 1.6 log10 copies/ml and 100% and 99% at the threshold of 3.0 log10 copies/ml. Conclusionthese results show that Xpert® HIV-1 Viral Load has excellent performance. In Senegal, and can be used for HIV viral load monitoring.</description><identifier>ISSN: 1937-8688</identifier><identifier>EISSN: 1937-8688</identifier><identifier>DOI: 10.11604/pamj.2022.42.136.32041</identifier><identifier>PMID: 36060855</identifier><language>eng</language><publisher>The African Field Epidemiology Network</publisher><subject>Project Evaluation</subject><ispartof>The Pan African medical journal, 2022-06, Vol.42, p.136-136</ispartof><rights>Pauline Yacine Sène et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9429987/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9429987/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Séne, Pauline Yacine</creatorcontrib><creatorcontrib>Diop-Ndiaye, Halimatou</creatorcontrib><creatorcontrib>Ndoye, Aissatou Sow</creatorcontrib><creatorcontrib>Kiernan, Brianan</creatorcontrib><creatorcontrib>Coulibaly, Khadidiatou</creatorcontrib><creatorcontrib>Ndiaye, Ousseynou</creatorcontrib><creatorcontrib>Diallo, Sada</creatorcontrib><creatorcontrib>Selbe Ndiaye, Anna Julienne</creatorcontrib><creatorcontrib>Fall, Mengue</creatorcontrib><creatorcontrib>Ba, Adjiratou Aissatou</creatorcontrib><creatorcontrib>Camara, Makhtar</creatorcontrib><creatorcontrib>Bouh Boye, Cheikh Saad</creatorcontrib><creatorcontrib>Ngom, Ndeye Fatou</creatorcontrib><creatorcontrib>Lejeune, Charlotte</creatorcontrib><creatorcontrib>Ndour, Cheikh Tidiane</creatorcontrib><creatorcontrib>Kane, Coumba Toure</creatorcontrib><title>Performance of Xpert HIV-1 viral load test in Senegal: a country of high circulation of CRF02_AG</title><title>The Pan African medical journal</title><description>Introductionthe introduction of the point-of-care in HIV-1 viral load quantification appears to be a complementary strategy to the existing conventional system of the acceleration plan for the achievement of the three 90s in Senegal. The objective of this study was to evaluate the performance of the Xpert® HIV-1 viral load in the context of circulation of non-B, non-C subtypes. Methodstwo hundred samples, were tested on Xpert® HIV-1 Viral Load using 1 ml of plasma in comparison to 600 μl on Abbott Real-time HIV-1 assay. The difference between viral load values was considered significant for Dlog <0.5 log copies/ml. Resultsa good correlation (r=0.985) was noted and confirmed using passing-bablok regression (slope 1.048; 95% CI: 1.036 to 1.069) for 188 samples with samples. A mean difference of 0.0075 log10 copies/ml for a 95% confidence interval (CI) of 0.002 log10 copies/ml to 0.013 log10 copies/ml was obtained. Sensitivity and specificity were respectively 93.6% and 93.5% at the threshold of 1.6 log10 copies/ml and 100% and 99% at the threshold of 3.0 log10 copies/ml. Conclusionthese results show that Xpert® HIV-1 Viral Load has excellent performance. In Senegal, and can be used for HIV viral load monitoring.</description><subject>Project Evaluation</subject><issn>1937-8688</issn><issn>1937-8688</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpVkclOwzAQhi0EomzPgI9cErzVCwckVAGtVAnEJm7GcezWKImLk1Ti7UmhQnCa0cw__8zoA-AUoxxjjtj5ytTvOUGE5IzkmPKcEsTwDjjAiopMcil3_-QjcNi27whxLinaByPKEUdyPD4Ab_cu-Zhq01gHo4evK5c6OJ29ZBiuQzIVrKIpYefaDoYGPrrGLUx1AQ20sW-69LkZWobFEtqQbF-ZLsRmU5s83CCir26PwZ43VetOtvEIPN9cP02m2fzudja5mmeWMtRllghKTMG84JSp0ngmDbalYGrMhVcYUSHtUJZesjHD3A_velyUhpSu8AWmR-Dyx3fVF7UrrRuOM5VepVCb9KmjCfp_pwlLvYhrrRhRSorB4GxrkOJHP_yr69BaV1WmcbFvNRFIKcwG9SAVP1KbYtsm53_XYKS_-egNH73hoxnRAx_9zYd-AQ5Ig2Y</recordid><startdate>20220620</startdate><enddate>20220620</enddate><creator>Séne, Pauline Yacine</creator><creator>Diop-Ndiaye, Halimatou</creator><creator>Ndoye, Aissatou Sow</creator><creator>Kiernan, Brianan</creator><creator>Coulibaly, Khadidiatou</creator><creator>Ndiaye, Ousseynou</creator><creator>Diallo, Sada</creator><creator>Selbe Ndiaye, Anna Julienne</creator><creator>Fall, Mengue</creator><creator>Ba, Adjiratou Aissatou</creator><creator>Camara, Makhtar</creator><creator>Bouh Boye, Cheikh Saad</creator><creator>Ngom, Ndeye Fatou</creator><creator>Lejeune, Charlotte</creator><creator>Ndour, Cheikh Tidiane</creator><creator>Kane, Coumba Toure</creator><general>The African Field Epidemiology Network</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220620</creationdate><title>Performance of Xpert HIV-1 viral load test in Senegal: a country of high circulation of CRF02_AG</title><author>Séne, Pauline Yacine ; Diop-Ndiaye, Halimatou ; Ndoye, Aissatou Sow ; Kiernan, Brianan ; Coulibaly, Khadidiatou ; Ndiaye, Ousseynou ; Diallo, Sada ; Selbe Ndiaye, Anna Julienne ; Fall, Mengue ; Ba, Adjiratou Aissatou ; Camara, Makhtar ; Bouh Boye, Cheikh Saad ; Ngom, Ndeye Fatou ; Lejeune, Charlotte ; Ndour, Cheikh Tidiane ; Kane, Coumba Toure</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-c2732ab4f76349daf48a1cd749567f910378cdaf8f845416f204f1bda2debfb13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Project Evaluation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Séne, Pauline Yacine</creatorcontrib><creatorcontrib>Diop-Ndiaye, Halimatou</creatorcontrib><creatorcontrib>Ndoye, Aissatou Sow</creatorcontrib><creatorcontrib>Kiernan, Brianan</creatorcontrib><creatorcontrib>Coulibaly, Khadidiatou</creatorcontrib><creatorcontrib>Ndiaye, Ousseynou</creatorcontrib><creatorcontrib>Diallo, Sada</creatorcontrib><creatorcontrib>Selbe Ndiaye, Anna Julienne</creatorcontrib><creatorcontrib>Fall, Mengue</creatorcontrib><creatorcontrib>Ba, Adjiratou Aissatou</creatorcontrib><creatorcontrib>Camara, Makhtar</creatorcontrib><creatorcontrib>Bouh Boye, Cheikh Saad</creatorcontrib><creatorcontrib>Ngom, Ndeye Fatou</creatorcontrib><creatorcontrib>Lejeune, Charlotte</creatorcontrib><creatorcontrib>Ndour, Cheikh Tidiane</creatorcontrib><creatorcontrib>Kane, Coumba Toure</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Pan African medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Séne, Pauline Yacine</au><au>Diop-Ndiaye, Halimatou</au><au>Ndoye, Aissatou Sow</au><au>Kiernan, Brianan</au><au>Coulibaly, Khadidiatou</au><au>Ndiaye, Ousseynou</au><au>Diallo, Sada</au><au>Selbe Ndiaye, Anna Julienne</au><au>Fall, Mengue</au><au>Ba, Adjiratou Aissatou</au><au>Camara, Makhtar</au><au>Bouh Boye, Cheikh Saad</au><au>Ngom, Ndeye Fatou</au><au>Lejeune, Charlotte</au><au>Ndour, Cheikh Tidiane</au><au>Kane, Coumba Toure</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Performance of Xpert HIV-1 viral load test in Senegal: a country of high circulation of CRF02_AG</atitle><jtitle>The Pan African medical journal</jtitle><date>2022-06-20</date><risdate>2022</risdate><volume>42</volume><spage>136</spage><epage>136</epage><pages>136-136</pages><issn>1937-8688</issn><eissn>1937-8688</eissn><abstract>Introductionthe introduction of the point-of-care in HIV-1 viral load quantification appears to be a complementary strategy to the existing conventional system of the acceleration plan for the achievement of the three 90s in Senegal. The objective of this study was to evaluate the performance of the Xpert® HIV-1 viral load in the context of circulation of non-B, non-C subtypes. Methodstwo hundred samples, were tested on Xpert® HIV-1 Viral Load using 1 ml of plasma in comparison to 600 μl on Abbott Real-time HIV-1 assay. The difference between viral load values was considered significant for Dlog <0.5 log copies/ml. Resultsa good correlation (r=0.985) was noted and confirmed using passing-bablok regression (slope 1.048; 95% CI: 1.036 to 1.069) for 188 samples with samples. A mean difference of 0.0075 log10 copies/ml for a 95% confidence interval (CI) of 0.002 log10 copies/ml to 0.013 log10 copies/ml was obtained. Sensitivity and specificity were respectively 93.6% and 93.5% at the threshold of 1.6 log10 copies/ml and 100% and 99% at the threshold of 3.0 log10 copies/ml. Conclusionthese results show that Xpert® HIV-1 Viral Load has excellent performance. In Senegal, and can be used for HIV viral load monitoring.</abstract><pub>The African Field Epidemiology Network</pub><pmid>36060855</pmid><doi>10.11604/pamj.2022.42.136.32041</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | African Journals Online (Open Access); Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Project Evaluation |
| title | Performance of Xpert HIV-1 viral load test in Senegal: a country of high circulation of CRF02_AG |
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