Fulminant Myocarditis 24 Days after Coronavirus Disease Messenger Ribonucleic Acid Vaccination
A 60-year-old Japanese woman was hospitalized for cardiogenic shock 24 days after receiving the second dose of the coronavirus disease 2019 BNT162b2 vaccine. Impella CP left ventricular assist device implantation and venoarterial peripheral extracorporeal membranous oxygenation were immediately init...
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| Veröffentlicht in: | Internal Medicine 2022/08/01, Vol.61(15), pp.2319-2325 |
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| container_title | Internal Medicine |
| container_volume | 61 |
| creator | Kawano, Hiroaki Motokawa, Tetsufumi Kurohama, Hirokazu Okano, Shinji Akashi, Ryohei Yonekura, Tsuyoshi Ikeda, Satoshi Izumikawa, Koichi Maemura, Koji |
| description | A 60-year-old Japanese woman was hospitalized for cardiogenic shock 24 days after receiving the second dose of the coronavirus disease 2019 BNT162b2 vaccine. Impella CP left ventricular assist device implantation and venoarterial peripheral extracorporeal membranous oxygenation were immediately initiated along with inotropic support and steroid pulse therapy, as an endomyocardial biopsy specimen showed myocarditis. Three weeks later, her cardiac function had recovered, and she was discharged. An immune response associated with the presence of spike protein in cardiac myocytes may be related to myocarditis in the present case because of positive immunostaining for severe acute respiratory syndrome coronavirus 2 spike protein and C4d in the myocardium. |
| doi_str_mv | 10.2169/internalmedicine.9800-22 |
| format | Article |
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Impella CP left ventricular assist device implantation and venoarterial peripheral extracorporeal membranous oxygenation were immediately initiated along with inotropic support and steroid pulse therapy, as an endomyocardial biopsy specimen showed myocarditis. Three weeks later, her cardiac function had recovered, and she was discharged. An immune response associated with the presence of spike protein in cardiac myocytes may be related to myocarditis in the present case because of positive immunostaining for severe acute respiratory syndrome coronavirus 2 spike protein and C4d in the myocardium.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.9800-22</identifier><identifier>PMID: 35650138</identifier><language>eng</language><publisher>Tokyo: The Japanese Society of Internal Medicine</publisher><subject>Biopsy ; Cardiomyocytes ; Case Report ; Coronaviruses ; COVID-19 ; Heart diseases ; Immune response ; inflammation ; Internal medicine ; Myocarditis ; Myocardium ; Myocytes ; Oxygenation ; pathology ; Severe acute respiratory syndrome coronavirus 2 ; Spike protein ; Vaccination ; Ventricle</subject><ispartof>Internal Medicine, 2022/08/01, Vol.61(15), pp.2319-2325</ispartof><rights>2022 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2022</rights><rights>Copyright © 2022 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c688t-43431a1ff3836c058349c792c36987bd989b35836e29465d2819ad3aa34cc1ee3</citedby><cites>FETCH-LOGICAL-c688t-43431a1ff3836c058349c792c36987bd989b35836e29465d2819ad3aa34cc1ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424077/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424077/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1877,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Kawano, Hiroaki</creatorcontrib><creatorcontrib>Motokawa, Tetsufumi</creatorcontrib><creatorcontrib>Kurohama, Hirokazu</creatorcontrib><creatorcontrib>Okano, Shinji</creatorcontrib><creatorcontrib>Akashi, Ryohei</creatorcontrib><creatorcontrib>Yonekura, Tsuyoshi</creatorcontrib><creatorcontrib>Ikeda, Satoshi</creatorcontrib><creatorcontrib>Izumikawa, Koichi</creatorcontrib><creatorcontrib>Maemura, Koji</creatorcontrib><title>Fulminant Myocarditis 24 Days after Coronavirus Disease Messenger Ribonucleic Acid Vaccination</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>A 60-year-old Japanese woman was hospitalized for cardiogenic shock 24 days after receiving the second dose of the coronavirus disease 2019 BNT162b2 vaccine. Impella CP left ventricular assist device implantation and venoarterial peripheral extracorporeal membranous oxygenation were immediately initiated along with inotropic support and steroid pulse therapy, as an endomyocardial biopsy specimen showed myocarditis. Three weeks later, her cardiac function had recovered, and she was discharged. An immune response associated with the presence of spike protein in cardiac myocytes may be related to myocarditis in the present case because of positive immunostaining for severe acute respiratory syndrome coronavirus 2 spike protein and C4d in the myocardium.</description><subject>Biopsy</subject><subject>Cardiomyocytes</subject><subject>Case Report</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Heart diseases</subject><subject>Immune response</subject><subject>inflammation</subject><subject>Internal medicine</subject><subject>Myocarditis</subject><subject>Myocardium</subject><subject>Myocytes</subject><subject>Oxygenation</subject><subject>pathology</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Spike protein</subject><subject>Vaccination</subject><subject>Ventricle</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNplUV1r3DAQFKWluaT9D4K-9MWJPmxZeimES9MEEgIh7WPFnry-6PBJqWQH7t9X5o6Dpi8r0M7Ozs4QQjk7F1yZCx9GTAGGLXbe-YDnRjNWCfGOLLisTdUK2bwnC2a4rkQpJ-Q05w1jUrdGfCQnslEN41IvyO_radj6AGGk97voIHV-9JmKml7BLlPoyyK6jCkGePVpyvTKZ4SM9B5zxrAu3Ue_imFyA3pHL53v6C9wRRSMPoZP5EMPQ8bPh_eM_Lz-_rS8qe4eftwuL-8qp7Qeq1rWkgPve6mlcqzR5QhXpDqpjG5XndFmJcuvQmFq1XRCcwOdBJC1cxxRnpFve96XaVVMcRjGBIN9SX4LaWcjePtvJ_hnu46v1tSiZm1bCL4eCFL8M2Ee7dZnh8MAAeOUrVCtaFnxTRTolzfQTZzmNGaUaXlbsuAFpfcol2LOCfujGM7sHKJ9G6KdQ7RiXvCwH93kEdZ4HIQ0-mLz_4OKW97M9cBwRLpnSBaD_As7KbGW</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Kawano, Hiroaki</creator><creator>Motokawa, Tetsufumi</creator><creator>Kurohama, Hirokazu</creator><creator>Okano, Shinji</creator><creator>Akashi, Ryohei</creator><creator>Yonekura, Tsuyoshi</creator><creator>Ikeda, Satoshi</creator><creator>Izumikawa, Koichi</creator><creator>Maemura, Koji</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220801</creationdate><title>Fulminant Myocarditis 24 Days after Coronavirus Disease Messenger Ribonucleic Acid Vaccination</title><author>Kawano, Hiroaki ; Motokawa, Tetsufumi ; Kurohama, Hirokazu ; Okano, Shinji ; Akashi, Ryohei ; Yonekura, Tsuyoshi ; Ikeda, Satoshi ; Izumikawa, Koichi ; Maemura, Koji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c688t-43431a1ff3836c058349c792c36987bd989b35836e29465d2819ad3aa34cc1ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biopsy</topic><topic>Cardiomyocytes</topic><topic>Case Report</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Heart diseases</topic><topic>Immune response</topic><topic>inflammation</topic><topic>Internal medicine</topic><topic>Myocarditis</topic><topic>Myocardium</topic><topic>Myocytes</topic><topic>Oxygenation</topic><topic>pathology</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Spike protein</topic><topic>Vaccination</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawano, Hiroaki</creatorcontrib><creatorcontrib>Motokawa, Tetsufumi</creatorcontrib><creatorcontrib>Kurohama, Hirokazu</creatorcontrib><creatorcontrib>Okano, Shinji</creatorcontrib><creatorcontrib>Akashi, Ryohei</creatorcontrib><creatorcontrib>Yonekura, Tsuyoshi</creatorcontrib><creatorcontrib>Ikeda, Satoshi</creatorcontrib><creatorcontrib>Izumikawa, Koichi</creatorcontrib><creatorcontrib>Maemura, Koji</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawano, Hiroaki</au><au>Motokawa, Tetsufumi</au><au>Kurohama, Hirokazu</au><au>Okano, Shinji</au><au>Akashi, Ryohei</au><au>Yonekura, Tsuyoshi</au><au>Ikeda, Satoshi</au><au>Izumikawa, Koichi</au><au>Maemura, Koji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fulminant Myocarditis 24 Days after Coronavirus Disease Messenger Ribonucleic Acid Vaccination</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2022-08-01</date><risdate>2022</risdate><volume>61</volume><issue>15</issue><spage>2319</spage><epage>2325</epage><pages>2319-2325</pages><artnum>9800-22</artnum><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>A 60-year-old Japanese woman was hospitalized for cardiogenic shock 24 days after receiving the second dose of the coronavirus disease 2019 BNT162b2 vaccine. Impella CP left ventricular assist device implantation and venoarterial peripheral extracorporeal membranous oxygenation were immediately initiated along with inotropic support and steroid pulse therapy, as an endomyocardial biopsy specimen showed myocarditis. Three weeks later, her cardiac function had recovered, and she was discharged. An immune response associated with the presence of spike protein in cardiac myocytes may be related to myocarditis in the present case because of positive immunostaining for severe acute respiratory syndrome coronavirus 2 spike protein and C4d in the myocardium.</abstract><cop>Tokyo</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>35650138</pmid><doi>10.2169/internalmedicine.9800-22</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; PubMed Central; PubMed Central Open Access |
| subjects | Biopsy Cardiomyocytes Case Report Coronaviruses COVID-19 Heart diseases Immune response inflammation Internal medicine Myocarditis Myocardium Myocytes Oxygenation pathology Severe acute respiratory syndrome coronavirus 2 Spike protein Vaccination Ventricle |
| title | Fulminant Myocarditis 24 Days after Coronavirus Disease Messenger Ribonucleic Acid Vaccination |
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