Increased PHOSPHO1 expression mediates cortical bone mineral density in renal osteodystrophy

Patients with advanced chronic kidney disease (CKD) often present with skeletal abnormalities, a condition known as renal osteodystrophy (ROD). While tissue non-specific alkaline phosphatase (TNAP) and PHOSPHO1 are critical for bone mineralization, their role in the etiology of ROD is unclear. To ad...

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Veröffentlicht in:Journal of endocrinology 2022-09, Vol.254 (3), p.153-167
Hauptverfasser: Hsu, Shun-Neng, Stephen, Louise A, Dillon, Scott, Milne, Elspeth, Javaheri, Behzad, Pitsillides, Andrew A, Novak, Amanda, Millán, Jose Luis, MacRae, Vicky E, Staines, Katherine A, Farquharson, Colin
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Sprache:eng
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