Ellagic Acid as a Potential Inhibitor against the Nonstructural Protein NS3 Helicase of Zika Virus: A Molecular Modelling Study

Zika virus is a member of the Flaviviridae family and genus Flavivirus, which has a phylogenetic relationship with spondweni virus. It spreads to humans through a mosquito bite. To identify potential inhibitors for the Zika virus with biosafety, we selected natural antiviral compounds isolated from...

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Veröffentlicht in:	BioMed research international 2022-08, Vol.2022, p.2044577-15
Hauptverfasser:	Kullappan, Malathi, Benedict, Balakrishnan Anna, Rajajagadeesan, Anusha, Baskaran, Padmasini, Periadurai, Nanthini Devi, Ambrose, Jenifer Mallavarpu, Gandhamaneni, Sri Harshini, Nakkella, Aruna Kumari, Agarwal, Alok, Veeraraghavan, Vishnu Priya, Surapaneni, Krishna Mohan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Binding sites Bioavailability Biosafety Crystal structure Dengue fever Disease transmission DNA helicase DNA Helicases - genetics Dynamic stability Ellagic Acid Encephalitis Enzymatic activity Fetuses Fibroblasts Flavivirus Genomes Guillain-Barre syndrome Health aspects Humans Hypericin Infections Ligands Molecular docking Molecular Docking Simulation Molecular dynamics Molecular modelling Mosquitoes Pharmacokinetics Phylogeny Phytochemicals Proteins RNA Helicases - genetics Serine Endopeptidases - genetics Stability analysis Trajectory analysis Transcription Vector-borne diseases Viral Nonstructural Proteins - chemistry Viral proteins Virus Replication Viruses Zika virus Zika Virus - chemistry Zika Virus Infection
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