Synthesis of Silver Nanocomposite Based on Carboxymethyl Cellulose: Antibacterial, Antifungal and Anticancer Activities
Traditional cancer treatments include surgery, radiation, and chemotherapy. According to medical sources, chemotherapy is still the primary method for curing or treating cancer today and has been a major contributor to the recent decline in cancer mortality. Nanocomposites based on polymers and meta...
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| Veröffentlicht in: | Polymers 2022-08, Vol.14 (16), p.3352 |
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| creator | Salem, Salem S Hashem, Amr H Sallam, Al-Aliaa M Doghish, Ahmed S Al-Askar, Abdulaziz A Arishi, Amr A Shehabeldine, Amr M |
| description | Traditional cancer treatments include surgery, radiation, and chemotherapy. According to medical sources, chemotherapy is still the primary method for curing or treating cancer today and has been a major contributor to the recent decline in cancer mortality. Nanocomposites based on polymers and metal nanoparticles have recently received the attention of researchers. In the current study, a nanocomposite was fabricated based on carboxymethyl cellulose and silver nanoparticles (CMC-AgNPs) and their antibacterial, antifungal, and anticancer activities were evaluated. The antibacterial results revealed that CMC-AgNPs have promising antibacterial activity against Gram-negative (Klebsiella oxytoca and Escherichia coli) and Gram-positive bacteria (Bacillus cereus and Staphylococcus aureus). Moreover, CMC-AgNPs exhibited antifungal activity against filamentous fungi such as Aspergillus fumigatus, A. niger, and A. terreus. Concerning the HepG2 hepatocellular cancer cell line, the lowest IC50 values (7.9 ± 0.41 µg/mL) were recorded for CMC-AgNPs, suggesting a strong cytotoxic effect on liver cancer cells. As a result, our findings suggest that the antitumor effect of these CMC-Ag nanoparticles is due to the induction of apoptosis and necrosis in hepatic cancer cells via increased caspase-8 and -9 activities and diminished levels of VEGFR-2. In conclusion, CMC-AgNPs exhibited antibacterial, antifungal, and anticancer activities, which can be used in the pharmaceutical and medical fields. |
| doi_str_mv | 10.3390/polym14163352 |
| format | Article |
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According to medical sources, chemotherapy is still the primary method for curing or treating cancer today and has been a major contributor to the recent decline in cancer mortality. Nanocomposites based on polymers and metal nanoparticles have recently received the attention of researchers. In the current study, a nanocomposite was fabricated based on carboxymethyl cellulose and silver nanoparticles (CMC-AgNPs) and their antibacterial, antifungal, and anticancer activities were evaluated. The antibacterial results revealed that CMC-AgNPs have promising antibacterial activity against Gram-negative (Klebsiella oxytoca and Escherichia coli) and Gram-positive bacteria (Bacillus cereus and Staphylococcus aureus). Moreover, CMC-AgNPs exhibited antifungal activity against filamentous fungi such as Aspergillus fumigatus, A. niger, and A. terreus. Concerning the HepG2 hepatocellular cancer cell line, the lowest IC50 values (7.9 ± 0.41 µg/mL) were recorded for CMC-AgNPs, suggesting a strong cytotoxic effect on liver cancer cells. As a result, our findings suggest that the antitumor effect of these CMC-Ag nanoparticles is due to the induction of apoptosis and necrosis in hepatic cancer cells via increased caspase-8 and -9 activities and diminished levels of VEGFR-2. In conclusion, CMC-AgNPs exhibited antibacterial, antifungal, and anticancer activities, which can be used in the pharmaceutical and medical fields.</description><identifier>ISSN: 2073-4360</identifier><identifier>EISSN: 2073-4360</identifier><identifier>DOI: 10.3390/polym14163352</identifier><identifier>PMID: 36015608</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Antibacterial agents ; Antibiotics ; Anticancer properties ; Antimicrobial agents ; Apoptosis ; Bacteria ; Cancer therapies ; Carboxymethyl cellulose ; Cellulose ; Chemotherapy ; Coliforms ; Cyclin-dependent kinases ; Drug resistance ; E coli ; Ethylenediaminetetraacetic acid ; Fungi ; Fungicides ; Health aspects ; Kinases ; Klebsiella ; Liver cancer ; Morphology ; Nanocomposites ; Nanoparticles ; Necrosis ; Pathogens ; Silver ; Vascular endothelial growth factor</subject><ispartof>Polymers, 2022-08, Vol.14 (16), p.3352</ispartof><rights>COPYRIGHT 2022 MDPI AG</rights><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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According to medical sources, chemotherapy is still the primary method for curing or treating cancer today and has been a major contributor to the recent decline in cancer mortality. Nanocomposites based on polymers and metal nanoparticles have recently received the attention of researchers. In the current study, a nanocomposite was fabricated based on carboxymethyl cellulose and silver nanoparticles (CMC-AgNPs) and their antibacterial, antifungal, and anticancer activities were evaluated. The antibacterial results revealed that CMC-AgNPs have promising antibacterial activity against Gram-negative (Klebsiella oxytoca and Escherichia coli) and Gram-positive bacteria (Bacillus cereus and Staphylococcus aureus). Moreover, CMC-AgNPs exhibited antifungal activity against filamentous fungi such as Aspergillus fumigatus, A. niger, and A. terreus. Concerning the HepG2 hepatocellular cancer cell line, the lowest IC50 values (7.9 ± 0.41 µg/mL) were recorded for CMC-AgNPs, suggesting a strong cytotoxic effect on liver cancer cells. As a result, our findings suggest that the antitumor effect of these CMC-Ag nanoparticles is due to the induction of apoptosis and necrosis in hepatic cancer cells via increased caspase-8 and -9 activities and diminished levels of VEGFR-2. In conclusion, CMC-AgNPs exhibited antibacterial, antifungal, and anticancer activities, which can be used in the pharmaceutical and medical fields.</description><subject>Antibacterial agents</subject><subject>Antibiotics</subject><subject>Anticancer properties</subject><subject>Antimicrobial agents</subject><subject>Apoptosis</subject><subject>Bacteria</subject><subject>Cancer therapies</subject><subject>Carboxymethyl cellulose</subject><subject>Cellulose</subject><subject>Chemotherapy</subject><subject>Coliforms</subject><subject>Cyclin-dependent kinases</subject><subject>Drug resistance</subject><subject>E coli</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Fungi</subject><subject>Fungicides</subject><subject>Health aspects</subject><subject>Kinases</subject><subject>Klebsiella</subject><subject>Liver cancer</subject><subject>Morphology</subject><subject>Nanocomposites</subject><subject>Nanoparticles</subject><subject>Necrosis</subject><subject>Pathogens</subject><subject>Silver</subject><subject>Vascular endothelial growth factor</subject><issn>2073-4360</issn><issn>2073-4360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptks9vFCEUxydGY5vao_dJvHhwKgwMDB5Mtht_NGnaQ_VMGHjTpWFgBWZ1_nvZttGuEQ7wHp_vl7yXV1WvMTojRKD32-CWCVPMCOnaZ9VxizhpKGHo-ZP7UXWa0h0qi3aMYf6yOipZ3DHUH1c_bxafN5BsqsNY31i3g1hfKR90mLYh2Qz1uUpg6uDrtYpD-LVMkDeLq9fg3OxCgg_1ymc7KJ0hWuXe3Yfj7G-Vq5U396FWXhfjlc52Z7OF9Kp6MSqX4PTxPKm-f_70bf21ubz-crFeXTaaEpIbQbFBpGMCE46FUYQYM4iOg-aUCcK1pqjnmrXaCNGbfhhFi6kiA-2KlCJyUn188N3OwwRGg89RObmNdlJxkUFZefji7Ubehp0s8lYgXAzePhrE8GOGlOVkky61Kw9hTrLliJdO8pYV9M0_6F2Yoy_l7SlGGC3QX6r0B6T1Yyj_6r2pXJWiKOkZF4U6-w9VtoHJ6uBhtCV_IGgeBDqGlCKMf2rESO6HRR4MC_kN0lSw3Q</recordid><startdate>20220817</startdate><enddate>20220817</enddate><creator>Salem, Salem S</creator><creator>Hashem, Amr H</creator><creator>Sallam, Al-Aliaa M</creator><creator>Doghish, Ahmed S</creator><creator>Al-Askar, Abdulaziz A</creator><creator>Arishi, Amr A</creator><creator>Shehabeldine, Amr M</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0024-3606</orcidid><orcidid>https://orcid.org/0000-0003-2898-6708</orcidid><orcidid>https://orcid.org/0000-0002-5510-1779</orcidid><orcidid>https://orcid.org/0000-0002-0136-7096</orcidid></search><sort><creationdate>20220817</creationdate><title>Synthesis of Silver Nanocomposite Based on Carboxymethyl Cellulose: Antibacterial, Antifungal and Anticancer Activities</title><author>Salem, Salem S ; 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According to medical sources, chemotherapy is still the primary method for curing or treating cancer today and has been a major contributor to the recent decline in cancer mortality. Nanocomposites based on polymers and metal nanoparticles have recently received the attention of researchers. In the current study, a nanocomposite was fabricated based on carboxymethyl cellulose and silver nanoparticles (CMC-AgNPs) and their antibacterial, antifungal, and anticancer activities were evaluated. The antibacterial results revealed that CMC-AgNPs have promising antibacterial activity against Gram-negative (Klebsiella oxytoca and Escherichia coli) and Gram-positive bacteria (Bacillus cereus and Staphylococcus aureus). Moreover, CMC-AgNPs exhibited antifungal activity against filamentous fungi such as Aspergillus fumigatus, A. niger, and A. terreus. Concerning the HepG2 hepatocellular cancer cell line, the lowest IC50 values (7.9 ± 0.41 µg/mL) were recorded for CMC-AgNPs, suggesting a strong cytotoxic effect on liver cancer cells. As a result, our findings suggest that the antitumor effect of these CMC-Ag nanoparticles is due to the induction of apoptosis and necrosis in hepatic cancer cells via increased caspase-8 and -9 activities and diminished levels of VEGFR-2. In conclusion, CMC-AgNPs exhibited antibacterial, antifungal, and anticancer activities, which can be used in the pharmaceutical and medical fields.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>36015608</pmid><doi>10.3390/polym14163352</doi><orcidid>https://orcid.org/0000-0002-0024-3606</orcidid><orcidid>https://orcid.org/0000-0003-2898-6708</orcidid><orcidid>https://orcid.org/0000-0002-5510-1779</orcidid><orcidid>https://orcid.org/0000-0002-0136-7096</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Antibacterial agents Antibiotics Anticancer properties Antimicrobial agents Apoptosis Bacteria Cancer therapies Carboxymethyl cellulose Cellulose Chemotherapy Coliforms Cyclin-dependent kinases Drug resistance E coli Ethylenediaminetetraacetic acid Fungi Fungicides Health aspects Kinases Klebsiella Liver cancer Morphology Nanocomposites Nanoparticles Necrosis Pathogens Silver Vascular endothelial growth factor |
| title | Synthesis of Silver Nanocomposite Based on Carboxymethyl Cellulose: Antibacterial, Antifungal and Anticancer Activities |
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