Ergosterol peroxide exhibits antiviral and immunomodulatory abilities against porcine deltacoronavirus (PDCoV) via suppression of NF-κB and p38/MAPK signaling pathways in vitro

•Porcine deltacoronavirus is an emerging virus posing economic and health burdens.•Now there are no effective antiviral agents against porcine deltacoronavirus (PDCoV).•Ergosterol peroxide downregulated the activation of the NF-κB and p38/MAPK pathways.•Ergosterol peroxide can inhibit PDCoV infectio...

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Veröffentlicht in:	International immunopharmacology 2021-04, Vol.93, p.107317-107317, Article 107317
Hauptverfasser:	Duan, Cong, Ge, Xinna, Wang, Junchi, Wei, Zhanyong, Feng, Wen-hai, Wang, Jiufeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral agents Antiviral Agents - pharmacology Apoptosis - drug effects Cell Line Coronavirus Infections - drug therapy Coronavirus Infections - immunology Coronavirus Infections - virology Cytokines - metabolism Deltacoronavirus - drug effects Deltacoronavirus - immunology Ergosterol - analogs & derivatives Ergosterol - chemistry Ergosterol - pharmacology Ergosterol peroxide I-kappa B Proteins - metabolism Immunologic Factors - chemistry Immunologic Factors - pharmacology LLC-PK1 Cells MAP Kinase Signaling System - drug effects NF-kappa B - metabolism NF-κB signaling pathway p38/MAPK signaling pathway Polyporaceae Porcine deltacoronavirus Swine Swine Diseases Transcription Factor RelA - metabolism Virion - drug effects Virus Replication - drug effects
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